Synthesis of 1,5-benzothiazepines: Part XXXII - Synthesis and antimicrobial studies of 8-substituted-2,5-dihydro-2-(4-pyridyl)-4-(2-thienyl)-1,5-benzothiazepines

1525-1530The reactions of 5-substituted-2-aminobcnzenethiols, the substituents being F, CI, Br, CH3, OCH3 and OC2H5 4a-f, with an α, β-unsaturated heterocyclic ketone, 3-(4-pyridyl)-1-(2-thienyl)-2-propcnone, have been carried out in dry toluene containing piperidine. The products, 8-substituted-2, 5-dihydro-2-(4-pyridyl)-4-(2-thicnyl)-1,5-benzothiazepines, 5a-f, obtained in 65-70% yields, have been characterized by microestimations for C, H, N and JR, 1H NMR and mass spectral studies. The synthesized compounds have been screened for antimicrobial activity against the bacteria Escherichia coli and <span style="mso-bidi-font-family: Arial;mso-bidi-language:HI">GPO and fungi, Aspergillus niger, Aspcrgillus flavus and Curvularia <span style="mso-bidi-font-family: Arial;mso-bidi-language:HI">lunata. <span style="mso-bidi-language: HI">All the compounds show good antibacterial and antifungal activity. </span

Synthesis of 1,5-benzothiazepines: Part XXX-Synthesis and antimicrobial studies of 10-substituted-6a, 7-dihydro-6<i>H </i>-7-(4-fluorophenyl)-6-phenyl [1] benzopyrano [3,4-<i>c</i>] [1,5] benzothiazepines

752-757 Flavindogenide, 3-(4-fluorobenzylidene)-flavanone has been reacted with six 5-substituted-2-aminobenzenethiols, the substituents being halogens as fluoro, chloro bromo, alkyl as methyl and alkoxyl as methoxyl and ethoxyl, to obtain a series of six new compounds, 10-substituted-6a,7-dihydro-6H-7-(4-fluorophenyl)-6-phenyl[1] benzopyrano[3,4-c][1,5]benzo­thiazepines 3a-f. The products are characterized on the basis of microanalytical data for elements and IR,1H NMR, 19F NMR and mass spectral studies. All the synthesized compounds have been evaluated for their antimicrobial activity against the bacteria Escherichia coli and GFC (Alteromonas tetraodonis - a new Gram-negative bacteria family) and fungi, Aspergillus niger, A. flavus and Curvularia lunata. All the compounds showed equal/greater bactericidal activity but for 3d showing lesser activity against E. coli and 3e against GFC. </smarttagtype

Photophysical Investigation of 8-amino 2-Naphthol in Different Micellar Environment

*8-amino 2-naphthol (8A2NP) is an interesting molecule containing both proton acceptor (-NH2) and proton donating (-OH) groups. Our earlier investigation on the photophysics / photochemistry of 8A2NP reveals that its prototropic behavior is sensitive to the solvent polarity and pH. Interesting photophysical properties of 8A2NP in homogeneous environment prompting towards the study of the said probe in in different surfactants. In the present work, 8A2NP has been studied in cationic (CTAB), anionic (SDS) and non-ionic (TX-100) surfactants and changes in the excited state deactivation are explored in the mentioned surfactant

Use of multilayer targets for achieving off-Hugoniot states

We present an approach for the realization of extreme off-Hugoniot states of matter in laser-driven shock experiments. The method is based on the application of impedance-mismatch effect in sandwich targets. In order to verify this model we have realized numerical simulations using the two-dimensional hydrocode MULTI in three-layer targets (gold-aluminum-gold) with laser intensities similar to 10(14) W/cm(2) and obtained pressures similar to 10 Mbar. Results show the possibility of obtaining high pressures with relatively small temperatures for a low-impedance material sandwiched between layers with high density material