Application of Multidimensional Force Sensor in Measuring Breeze Speed

For the measurement of the micro wind speed, the size, accuracy and sensitivity of the measurement device have higher requirements, so most wind speed measurement instruments are difficult to achieve the wind speed measurement standards in the market. Based on the principle of wind load, the method of measuring wind speed using MEMS multidimensional force sensor is studied. Through the wind the ball, the sensor sensitive beam with sensitive strain measure pressure from X, Y, Z direction. Effective synthetic velocity and resultant wind direction can be obtained, through the relationship between pressure and wind velocity. Compared with the conventional mechanical wind speed measuring instruments on the market, it has the characteristics of simple structure and fast responding, and has no traditional mechanical components

Status and Influencing Factors of Health Information Literacy of the Rural Elderly

[Purpose/Significance] In China, the elderly population is huge, and the degree of aging is obviously accelerating. The gap between urban and rural areas is obvious, with the proportion of the elderly population in rural areas being higher than that in urban areas. Along with the accelerating aging process, the health problems faced by the elderly are becoming more and more prominent, and the demand for personal health information literacy will be increasing. Research on health information literacy and health promotion among the elderly, especially the rural elderly, will become an important topic. Therefore, it is important to understand the current situation of health information literacy among rural elderly and explore its influencing factors in order to establish ways and mechanisms to successfully promote health information literacy among rural elderly. [Method/Process] This paper used a mixed approach combining literature review and quantitative research. Firstly, we formulated a questionnaire and proposed a hypothesis on the influence of socio-demographic factors on health information literacy through a review of relevant studies and investigation tools at home and abroad. Then, based on the theoretical model of knowledge, attitudes and behavior and the connotation of health information literacy, we proposed some hypotheses on the interactions between the dimensions of health information literacy. Finally, in the quantitative study, a three-stage sampling was used to conduct a household questionnaire survey of elderly people aged 60 and above in rural areas, and a total of 1 222 valid questionnaires were obtained and the hypothesis testing was performed using regression analysis and path analysis. [Results/Conclusions] The score of health information literacy of rural elderly is lower, the score of health information consciousness dimension is the highest, and the score of health information seeking dimension is the lowest. Education level, time of using smart phones, time of using the Internet, nature of work and health status are the important influencing factors of health information literacy of rural elderly (P<0.05). The most trusted source of health information for rural elderly is medical workers, but they feel it difficult to evaluate and distrust online information. Therefore, strengthening the participation of medical staff in health information literacy education for the elderly and alleviating the conflicts in use of smart phones and the Internet by elderly should be done in order to achieve effective improvement of the health information literacy of the elderly in rural areas. In addition, there are some limitations in this study. The sample size is not large enough, as well as not exploring in depth the factors influencing health information literacy from other factors such as health information behaviors of rural older adults, which will be studied in the future

Bazedoxifene Plays a Protective Role against Inflammatory Injury of Endothelial Cells by Targeting CD40

The inflammatory response and oxidative stress play key roles in the formation and development of atherosclerosis. Bazedoxifene is a new IL6/GP130 inhibitor recommended by the FDA for clinical use as a selective estrogen receptor modulator. However, its role in cardiovascular diseases has been poorly studied. In our study, we explored the mechanism of bazedoxifene’s protective effect against inflammatory injury of vascular endothelial cells (VECs) stimulated by TNF-α. Various methods were used to verify the effect of bazedoxifene on VECs, including a cell viability assay, a wound healing assay, immunofluorescence staining, and western blotting. Our results showed that TNF-α could induce inflammatory damage to VECs, which manifested as upregulated expression of CD40, increased production of ROS, enhanced adhesion of THP-1 cells to VECs, and impaired viability and migration of VECs, while bazedoxifene could significantly reduce the endothelial damage caused by TNF-α. In addition, we found that an siRNA targeting CD40 dramatically alleviated the VEC damage induced by TNF-α. Therefore, we explored the potential relationship between bazedoxifene and CD40. Our data suggest that bazedoxifene has a protective effect against VEC damage induced by TNF-α and that its underlying mechanism may be related to the regulation of CD40