Mihai Gheorghiade, MD-Life and Concepts

How do you capture an idea, shape it, and then bring it into the world? Of his many talents, this ability was a fundamental characteristic of Mihai Gheorghiade. A quick glance through PubMed confirms his prodigious output, likely to overwhelm any novice or even expert scholar. His contribution to heart failure, especially acute heart failure (AHF), is profound, He authored several major concepts in acute heart failure, disseminated further by his students. Most concepts remained indelibly linked to his name: Digoxin trials research(1–3), AHFS (acute heart failure syndromes) definition(4), hemodynamic congestion(5), hospitalized heart failure (HHF) (6), the vulnerable phase(7,8), neutral hemodynamic agents(9), registries(10–12) and pre-trial registries(13), the “6-axis model”(14) and then the “8-axis model”(15). His work shaped the field of AHF

Effects of initial flow velocity fluctuation in event-by-event (3+1)D hydrodynamics

Hadron spectra and elliptic flow in high-energy heavy-ion collisions are studied within a (3+1)D ideal hydrodynamic model with fluctuating initial conditions given by the AMPT Monte Carlo model. Results from event-by-event simulations are compared with experimental data at both RHIC and LHC energies. Fluctuations in the initial energy density come from not only the number of coherent soft interactions of overlapping nucleons but also incoherent semi-hard parton scatterings in each binary nucleon collision. Mini-jets from semi-hard parton scatterings are assumed to be locally thermalized through a Gaussian smearing and give rise to non-vanishing initial local flow velocities. Fluctuations in the initial flow velocities lead to harder transverse momentum spectra of final hadrons due to non-vanishing initial radial flow velocities. Initial fluctuations in rapidity distributions lead to expanding hot spots in the longitudinal direction and are shown to cause a sizable reduction of final hadron elliptic flow at large transverse momenta.Comment: 17 pages in RevTex, 18 figures, final version published in PR

Improving Postdischarge Outcomes in Acute Heart Failure

The global burden that acute heart failure (AHF) carries has remained unchanged over the past several decades (1). European registries (2–5) showed that 1-year outcome rates remain unacceptably high (Table 1) and confirm that hospitalization for AHF represents a change in the natural history of the disease process(6). As patients hospitalized for HF have a bad prognosis, it is crucial to utilize hospitalization as an opportunity to: 1) assess the individual components of the cardiac substrate; 2) identify and treat comorbidities; 3) identify early, safe endpoints of therapy to facilitate timely hospital discharge and outpatient follow-up; and 4) implement and begin optimization guideline-directed medical therapies (GDMTs). As outcomes are influenced by many factors, many of which are incompletely understood, a systematic approach is proposed that should start with admission and continues through post-discharge (7)

A Trouble with Ho\v{r}ava-Lifshitz Gravity

We study the structure of the phase space in Ho\v{r}ava-Lifshitz theory. With the constraints derived from the action, the phase space is described by five fields, thus there is a lack of canonical structure. The Poisson brackets of the Hamiltonian density do not form a closed structure, resulting in many new constraints. Taking these new constraints into account, it appears that there is no degree of freedom left, or the phase space is reduced to one with an odd number of fields.Comment: 12 pages, some discussions, comments and references added, JHEP styl