183 research outputs found
Avaliação de diferentes métodos de seleção em população de bovinos de duplo propósito através de simulação genética.
Targeting of the adaptor protein Tab2 as a novel approach to revert tamoxifen resistance in breast cancer cells.
Programa de melhoramento genético da raça girolando - Avaliação genética de vacas - junho/2016.
A Embrapa Gado de Leite e a Associação Brasileira dos Criadores de Girolando realizam anualmente avaliações genéticas de vacas e de touros, com dados obtidos do Programa de Melhoramento Genético da Raça Girolando (PMGG). Desde 2013 as avaliações genéticas das principais fêmeas Girolando passaram a ser divulgadas em Sumário de vacas, contendo as 1.000 vacas de maiores PTAs para a produção de leite. Dessa forma, os criadores terão conhecimento das vacas de maior potencial genético na população Girolando. Tal conhecimento certamente possibilitará selecionar, de modo mais eficiente, as vacas que poderão ser mães de touros e aquelas a serem submetidas a biotecnologias reprodutivas como a transferência de embriões (TE) e técnicas relacionadas, como a clonagem e transferência de genes.bitstream/item/145080/1/DOC-192-Sumario-Vacas-2016.pd
Genetic characterization of Indubrasil cattle breed population.
Abstract The Indubrasil breed was developed in the Brazilian region called Triângulo Mineiro as a result of a cross between zebu cattle. Initially, it was used as a terminal cross and currently it represents approximately 4.45% of all the Brazilian zebu cattle. Studies were conducted to estimate genetic parameters in the Indubrasil using pedigree information, however, until now, no study has been developed using large-scale genomic markers in this breed. Pedigree information are widely used to investigate population parameters; however, they can neglect some estimates when compared to the use of genomic markers. Therefore, the objective of this study was to investigate the population structure and the genetic diversity of Indubrasil cattle using a high-density Single Nucleotide Polymorphism (SNP) panel (Illumina BovineHD BeadChip 700k). Levels of genomic homozygosity were evaluated using three different approaches: Runs of homozygosity (FROH), % of homozygosis (FSNP), and inbreeding coefficient (Fx). Further, Runs of Homozygosity (ROH) segments conserved among the animals were investigated to identify possible regions associated with the breed characteristics. Our results indicate that even the Indubrasil breed having a small effective population size, the levels of homozygosity (FROH = 0.046) are still small. This was possibly caused by the cross conducted among different breeds for its development. It suggests no immediate risks associated with loss of genetic variation. This information might be used in breeding programs, for the breed conservation and for the expansion of the Indubrasil breed
Red Sindhi cattle in Brazil: population structure and distribution.
The Red Sindhi cattle breed was imported to Brazil in small numbers. Nowadays, the herds of this breed are distributed in the Northeast, Southeast and Midwest regions of the country. In this study, DNA samples of animals originating from 15 herds in the Northeast and Southeast regions have been analyzed to obtain the ancestry proportions, and to gain a better understanding of the current population structure of this breed in Brazil. Samples were genotyped using three different single nucleotide polymorphism (SNP) marker panels. Those markers have been used with the approach of unsupervised hierarchical clustering of individuals, and consequently, the ancestry of the population was divided into six different subpopulations. Three of those ancestry subpopulations were identified to be present in various different herds, while the other three were restricted to only one or two herds each. One of those herds has been kept isolated for more than 30 years, and it was identified to contain two almost exclusive subpopulations. To avoid important losses in the genetic diversity within the Red Sindhi breed in Brazil, we recommend the identification of superior sires from every subpopulation in the establishment of a breeding program for this breed
Candidate genes for milk, growth and immune system traits in Brazilian Iberian: derived Locally Adapted cattle breeds.
Along decades of breeding in a variable ecosystem throughout the country, the first taurine animals arrived in Brazil became adapted to a wide range of environments with different levels of improved fitness. We analyzed three cattle breeds representative of Brazilian Iberianderived Locally Adapted cattle (Curraleiro Pé-Duro CUR with 17 animals, and both Caracu lineages, Caracu Caldeano selected for milk ? CCD with 55 animals, and Caracu selected for beef -?CCB with 24) aimed to evaluate runs of homozygosity (ROH), identify ROH islands and functionally analyse the identified genes. We observed the occurrence of short ROH islands in all breeds, suggesting a successful matting scheme. Genes located in ROH islands were evaluated and explored throughout their biological processes (e.g. PRLR related with milk and growth traits in CCD and CCB; and CAMKK2 related with immune system in CUR) providing information about the genetic architecture of the breeds
Programa Nacional de Melhoramento do Guzerá para Leite: resultados do Teste de Progênie, do Programa de Melhoramento Genético de Zebuínos da ABCZ e do Núcleo MOET.
bitstream/item/37081/1/Doc-144-Guzera.pd
The Challenges of Adopting PLM Tools Involving Diversified Technologies in Today’s Automotive Supplier Business
In order to reduce product development (PD) costs and duration, PD cycles are being accelerated in order to reduce the time to market and satisfy the end customer needs. Another key challenge in PD today, is product diversification in the technologies used, requiring improved collaboration amongst local and dispersed multi disciple PD teams. A main stream tool that aids and support engineers in PD to collaborate and share information/knowledge is Product Lifecycle Management (PLM). This research explores the benefits and requirements of implementing a PLM system for a PD and manufacturing company within the automotive supply chain. This paper first provides a brief background of the subject area, followed by an explanation of the initial industrial investigation for the implementation of a PLM system, from which investigation the resulting conclusions and recommendations are presented as the building blocks of the implementation project
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