The Infinite Index: Information Retrieval on Generative Text-To-Image Models

Conditional generative models such as DALL-E and Stable Diffusion generate images based on a user-defined text, the prompt. Finding and refining prompts that produce a desired image has become the art of prompt engineering. Generative models do not provide a built-in retrieval model for a user's information need expressed through prompts. In light of an extensive literature review, we reframe prompt engineering for generative models as interactive text-based retrieval on a novel kind of "infinite index". We apply these insights for the first time in a case study on image generation for game design with an expert. Finally, we envision how active learning may help to guide the retrieval of generated images.Comment: Final version for CHIIR 202

Emerging treatments in the management of schizophrenia – focus on sertindole

The antipsychotic treatment of schizophrenia is still marked by poor compliance, and drug discontinuation; the development of more effective and safer drugs still remains a challenge. Sertindole is a second-generation antipsychotic with high affinity for dopamine D2, serotonin 5-HT2A, 5-HT2C, and α1-adrenergic receptors, and low affinity for other receptors. Sertindole undergoes extensive hepatic metabolism by the cytochrome P450 isoenzymes CYP2D6 and CYP3A4 and has an elimination half-life of approximately three days. In controlled clinical trials sertindole was more effective than placebo in reducing positive and negative symptoms, whereas it was as effective as haloperidol and risperidone against the positive symptoms of schizophrenia. The effective dose-range of sertindole is 12–20 mg, administered orally once daily. The most common adverse events are headhache, insomnia, rhinitis/nasal congestion, male sexual dysfunction, and moderate weight gain, with few extrapyramidal symptoms and metabolic changes. Sertindole is associated with corrected QT interval prolongation, with subsequent risk of serious arrythmias. Due to cardiovascular safety concerns, sertindole is available as a second-line choice for patients intolerant to at least one other antipsychotic agent. Further clinical studies, mainly direct “head-to-head” comparisons with other second-generation antipsychotic agents, are needed to define the role of sertindole in the treatment of schizophrenia

Abnormal illness behavior and Internet addiction severity: The role of disease conviction, irritability, and alexithymia

While the association between health anxiety and maladaptive Internet use is a well-established finding, no studies have been performed to examine the possible effect of abnormal illness behavior (AIB). AIB is a maladaptive manner of experiencing, evaluating, or acting in response to health and illness that is disproportionate to evident pathology. The aim of this study was to investigate the association between AIB and Internet addiction (IA) severity in a sample of Italian University students. The possible effect of alexithymia, anxiety, and depression was also taken into account. Methods Participants were 115 men and 163 women (mean age = 23.62 ± 4.38 years); AIB was measured via the Illness Behavior Questionnaire (IBQ), and IA severity by the Internet Addiction Test (IAT). Results The most powerful IBQ factor predicting IA severity scores was disease conviction. Irritability was the only emotional IBQ factor associated with IA severity. Nevertheless, disease conviction and alexithymia remained the only significant predictors of IAT scores when hierarchical regression analysis was executed. Discussion and conclusions Our results support previous findings showing that those characterized by health anxiety are more prone to an excessive and maladaptive use of Internet. Moreover, this study showed that irritability was the only emotional aspect of AIB predicting IA severity. This finding is consistent with the cognitive model of hypochondria, which states that cognitive factors (dysfunctional beliefs and assumptions) play a major role in the explanation of this psychopathological condition

Affective temperaments and personality traits in couple well-being

Background. The objective of this study is to establish the link between affective temperament traits and maladaptive personality traits, to verify whether the potential presence of elements related to emotional, affective and dysfunctional relational functioning can affect the couple satisfaction, modifying the well-being or discomfort condition. Materials and Methods. A data collection questionnaire was developed to investigate the factors associated with dysfunctional emotional, affective, and relational modes of functioning. The sample consisted of 473 subjects. Data were collected including the TEMPS-A questionnaire, The Dirty Dozen Italian Assessment and the Relationship Assessment Scale (RAS). Results. The findings of this study showed that the subscales of affective temperament were predictors of dark triad traits. The expressive, irritable and hyperthymic temperamental traits were found to be predictors of trait psychopathy; hyperthymic temperament is also a predictor of narcissistic traits and cyclothymic temperament is a predictor of lower couple satisfaction; men show higher scores than women in Dark triad. Conclusions. This study confirmed that temperamental traits can predict maladaptive personality traits belonging to the dark triad and confirms the importance of evaluating maladaptive personality traits to prevent forms of psychological violence in couple

The Role of Basic Symptoms and Aberrant Salience in Borderline Personality Disorder

Background: The prevalence of pre-psychotic symptoms and aberrant salience in BPD has not been systematically studied. The present study aims to investigate the intensity, frequency and correlation between basic symptoms, aberrant salience and borderline personality traits, in subjects that have not yet developed a frank psychotic episode.  Methods: Twenty-eight subjects, 8 males and 20 females, aged between 24 and 55 years (M = 41.36 ± 9.9) has been individually tested throughout the Frankfurt Complaint Questionnaire (FBF), the Aberrant Salience Inventory (ASI) and the Personality Inventory for the DSM-5- Adult (PID-5).  Results: Findings showed that 85.7% of the sample (n = 24) reported significant scores of the aberrant salience traits, which in turn were correlated to basic symptoms. Furthermore, emerged several correlations between pre-psychotic symptoms and PID-5 personality dimensions not only with Negative Affectivity and Detachment but also with Psychoticism. Conclusions: This study highlights the phenomenological continuity between the borderline personality traits and the attenuated manifestation of the psychotic disease

Somatic Symptom Disorder: a narrative review of literature of the last twenty years

Background: according to the DSM-5, somatic symptom disorder (SSD) is characterized by physical symptoms that cause a disruption in patient functioning and by excessive preoccupation about symptoms. There is a high prevalence of SSD in the general population, with a range going from 5 to 7% and with a relevant cost burden for healthcare system. So, it appears useful to know what the state of art regarding this significant problem is. Methods: the aim of this work is to review studies published in the last twenty years, using Pubmed, Scopus, Cochrane and PsichInfo, as search engines and the following terms: “somatic symptom disorder”, “somatization”, “somatoform disorder”, “medically unexplained symptoms”, “bodily distress syndrome” and “psychosomatic medicine”, linked by the Boolean operator “OR”. Exclusion criteria are studies in languages other than English and French, studies about pediatric population and animals, type of publication other than journal articles. Results: etiology of SSD is multifactorial, involving internal and external factors. Neuroanatomical studies show the presence of abnormalities in CNS of SSD patients. Assessment still results a problematic field, due to uncertainty of nosography. The therapeutic approach toward SSD can be pharmacological, but also the psychotherapy in its different approaches. Conclusions: the issue of SSD is complex and needs further investigations. To correctly analyze this phenomenon, it is necessary to consider both psychological and organic factors, being on the base of this disorder. It is worth to develop this research because an improvement of the state of art about this matter could lead to improve the approach to SSD, resulting in better quality of patients’ life

A Combined Clustering and Multi-Criteria Approach for Portfolio Selection

One of the key role of a portfolio manager is to identify a suitable asset allocation strategy. The portfolio composition task has to take into account the return and the risk of each asset along with several other factors such as investor’s aims, market expectations and risk tolerance. Thus the final decision making can be naturally viewed as a multiple criteria problem whose solution can benefit from Multiple Criteria Decision Making strategies. In this paper, we propose a two-step multi-criteria approach to support the selection of equity portfolios. Our strategy exploits a varying-coefficient Capital Asset Pricing Model framework. First, we identify clusters of stocks having similar systematic risk factors, then we rank these assets using an ELECTRE III method. We also present a real data example on stocks of S&P500 to illustrate the proposed methodology

The Relationship between Alexithymia, Anxiety, Depression, and Internet Addiction Severity in a Sample of Italian High School Students

We aimed to assess whether Internet addiction (IA) severity was related to alexithymia scores among high school students, taking into account the role of gender differences and the possible effect of anxiety, depression, and age. Participants in the study were 600 students (ages ranging from 13 to 22; 48.16% girls) recruited from three high schools in two cities from Southern Italy. Participants completed a sociodemographic questionnaire, the Toronto Alexithymia Scale, the Internet Addiction Test, the Hamilton Anxiety Scale, and the Hamilton Depression Scale. The findings of the study showed that IA scores were associated with alexithymia scores, over and above the effect of negative emotions and age. Students with pathological levels of alexithymia reported higher scores on IA severity. In particular, results showed that difficulty in identifying feelings was significantly associated with higher scores on IA severity. No effect of gender was found. Implications for clinicians were discussed