Dynamic behaviour analysis of an english-bond masonry prototype using a homogenized-based discrete FE model

Full Finite Element strategies (the so called micro- and macro- models) are still nowadays the most used ones for the study of large masonry structures. However, macro-modelling still lacks accuracy at a meso-scale in terms of damage localization. On the other hand, micro-models are rather computational demanding and require a cumbersome modelling stage. Thus, homogenization-based frameworks give considerable advantages. Moreover, the study of English bond masonry appears to be disregarded in comparison to the running bond one. On this behalf, a two-step procedure based on homogenization theory is herein presented for the dynamic study of English-bond masonry structures. The presented homogenization approach uses two models at a micro-scale: (i) a plane-stress FE discretization within the concepts of Kirchhoff-Love plate theory; and (ii) a three-dimensional micro-model accounting with the mortar joint discontinuity existent at the thickness direction. Bricks are meshed with elastic elements with linear interpolation and joints are reduced to interfaces which obey to the nonlinear behaviour described by the so-called combined cracking-shearing-crushing model. The procedure allows obtaining homogenized bending moment/torque curvature relationships to be used at a structural level within a FE discrete model implemented in a commercial code. The model relies in rigid quadrilateral elements interconnected by homogenized bending/torque nonlinear springs. The framework is used to study the dynamic behaviour of an English-bond masonry wall benchmark. A macroscopic strategy is also considered to enrich the study. The numerical results are compared with the experimental data and a good agreement has been found.FCT (Portuguese Foundation for Science and Technology), within ISISE, scholarship SFRH/BD/95086/2013. This work was also partly financed by FEDER funds through the Competitivity Factors Operational Programme - COMPETE and by national funds through FCT – Foundation for Science and Technology within the scope of the project POCI-01-0145-FEDER-00763

An Efficient Targeted Drug Delivery through Apotransferrin Loaded Nanoparticles

BACKGROUND: Cancerous state is a highly stimulated environment of metabolically active cells. The cells under these conditions over express selective receptors for assimilation of factors essential for growth and transformation. Such receptors would serve as potential targets for the specific ligand mediated transport of pharmaceutically active molecules. The present study demonstrates the specificity and efficacy of protein nanoparticle of apotransferrin for targeted delivery of doxorubicin. METHODOLOGY/PRINCIPAL FINDINGS: Apotransferrin nanoparticles were developed by sol-oil chemistry. A comparative analysis of efficiency of drug delivery in conjugated and non-conjugated forms of doxorubicin to apotransferrin nanoparticle is presented. The spherical shaped apotransferrin nanoparticles (nano) have diameters of 25-50 etam, which increase to 60-80 etam upon direct loading of drug (direct-nano), and showed further increase in dimension (75-95 etam) in conjugated nanoparticles (conj-nano). The competitive experiments with the transferrin receptor specific antibody showed the entry of both conj-nano and direct-nano into the cells through transferrin receptor mediated endocytosis. Results of various studies conducted clearly establish the superiority of the direct-nano over conj-nano viz. (a) localization studies showed complete release of drug very early, even as early as 30 min after treatment, with the drug localizing in the target organelle (nucleus) (b) pharmacokinetic studies showed enhanced drug concentrations, in circulation with sustainable half-life (c) the studies also demonstrated efficient drug delivery, and an enhanced inhibition of proliferation in cancer cells. Tissue distribution analysis showed intravenous administration of direct nano lead to higher drug localization in liver, and blood as compared to relatively lesser localization in heart, kidney and spleen. Experiments using rat cancer model confirmed the efficacy of the formulation in regression of hepatocellular carcinoma with negligible toxicity to kidney and liver. CONCLUSIONS: The present study thus demonstrates that the direct-nano is highly efficacious in delivery of drug in a target specific manner with lower toxicity to heart, liver and kidney

Numerical modelling of reinforced unpaved roads

A finite element model capable of computing the behaviour of a reinforced unpaved road deforming in plane strain is described. Elastic perfectly-plastic soil models are used which are based on the use of the von Mises yield function for cohseive soils and the Matsuoka criterion for frictional material. The reinforcement is modelled using elastic membrane elements. The formulation is based on a large strain, large displacement Eulerian approach. The finite element model is used to back-analyse laboratory scale model tests in which a footing is jacked monotonically into a model reinforced unpaved road. Some selected results of these back-analysis calculations are presented. -Author