Primer sequences which were used for Sanger Sequencing.

A combination of a forward and reverse primers from the table were used for a targeted sequencing for each hypervariable segment. (XLSX)</p

Comprehensive statistical analysis between Cyprus and countries of interest.

The genetic distances were calculated between Cypriots and countries of interest using the Arlequin software, providing information regarding their genetic differentiation. (XLSX)</p

Number and percentage of individuals from Southeast Europe, the Near East and North Africa that share haplotypes^a with Cypriots.

<p>Number and percentage of individuals from Southeast Europe, the Near East and North Africa that share haplotypes<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0179474#t001fn001" target="_blank">^a</a> with Cypriots.</p

Y-haplogroup frequencies among Greek Cypriots, Turkish Cypriots, Greeks and Turks.

<p>Population codes as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0179474#pone.0179474.s012" target="_blank">S5 Table</a>.</p

Pairwise genetic distance (Rst) between Cypriots and populations from Southeast Europe, the Near East and North Africa.

<p>Pairwise genetic distance (Rst) between Cypriots and populations from Southeast Europe, the Near East and North Africa.</p

PCA plots based on Y-haplogroup frequencies showing relative genetic distances between Cypriots and surrounding populations.

<p>PCA plots based on Y-Haplogroup frequencies showing relative genetic distances between Cypriots, Greeks, Turks and other populations and sub-populations from the Central and Eastern Mediterranean and Near East regions (a), and after predicting the pre-Ottoman Y-haplogroup distribution of Cypriots, assuming no possible proto-Turkic admixture into Cyprus (b). Population codes as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0179474#pone.0179474.s012" target="_blank">S5 Table</a>.</p

Distribution of mtDNA haplogroups between Cypriot PD patients and controls and Odds Ratios (95% Confidence Intervals) showing their association with PD.

<p>Distribution of mtDNA haplogroups between Cypriot PD patients and controls and Odds Ratios (95% Confidence Intervals) showing their association with PD.</p

Odds Ratios (95% Confidence Intervals) showing associations between mitochondrial haplogroup clusters and superclusters and PD.

<p>Odds Ratios (95% Confidence Intervals) showing associations between mitochondrial haplogroup clusters and superclusters and PD.</p