Antiplasmodial and Cytotoxic Flavans and Diarylpropanes from the Stems of <i>Combretum griffithii</i>

Four new flavans, griffinoids A–D (<b>1</b>–<b>4</b>), and two new diarylpropanes, griffithanes E and F (<b>7</b> and <b>8</b>), together with two known flavans (<b>5</b> and <b>6</b>), four known diarylpropanes, and β-sitosterol, were isolated from the EtOAc extract of the stems of <i>Combretum griffithii</i>. Compounds <b>3</b>, <b>4</b>, <b>5</b>, and <b>9</b> exhibited weak antiplasmodial activity, with IC₅₀ values of 15.74, 13.04, 9.66, and 14.45 μM, respectively. In addition, compounds <b>4</b>, <b>5</b>, and <b>8</b> also exhibited weak cytotoxicity toward one or more cancer cell lines including human epidermoid carcinoma, human breast cancer, and human small cell lung cancer cell lines

Phytochemical investigation and acetylcholinesterase inhibitory activity of bark of <i>Hymenodictyon orixense</i>

<p>The chemical investigation of the methanol extract of <i>Hymenodictyon orixense</i> bark, a Thai medicinal herb, provided five compounds. Their structures were identified on the basis of 1D NMR and MS data, as well as by comparison of the data with published values, as an iridoid glycoside: loganin (<b>1</b>), four coumarins: scopoletin (<b>2</b>), scopolin (<b>3</b>), hymexelsin (<b>4</b>) and scopoletin 7-<i>O</i>-<i>β</i>-D-xylopyranosyl-(1→6)-<i>β</i>-D-glucopyranoside (<b>5</b>). Compounds <b>1–5</b> showed acetylcholinesterase (AChE) inhibitory activity in the range of 13.92–34.18% at a concentration of 100 <i>μ</i>g/mL. In addition, compounds <b>1</b> and <b>5</b> are reported for the first time from this genus.</p