2 research outputs found
A Rare Pancreatic Tail Metastasis from Squamous Cell Lung Carcinoma Diagnosed by EUS-FNB and a Small Review of the Literature
Differential diagnosis of pancreatic lesions is really challenging, especially when the patient is diagnosed with primary cancer at another site. In this case report, we managed to histologically confirm pancreatic metastasis from squamous cell lung carcinoma, which is a very rare entity, using endoscopic ultrasound fine needle biopsy
Higher Incidence of Tall Cell Variant of Papillary Thyroid Carcinoma in Graves' Disease
Background: Patients with Graves’ disease (GD) and thyroid nodules have
an elevated risk of developing thyroid carcinomas, which is primarily
accounted for by well-differentiated tumors. Among these tumors, certain
histological variants, such as the diffuse sclerosing and tall cell
carcinoma, are characterized by a more aggressive behavior. The aim of
this study was to evaluate the incidence, the clinical behavior in
relation to histological variants, and the outcome of papillary thyroid
carcinoma (PTC) in a cohort of patients with GD who had undergone
thyroidectomy. Methods: A total of 2188 patients who underwent total
thyroidectomy participated in this retrospective, nonrandomized,
population-based study at a General Hospital. Of these patients, 181 had
GD. The parameters examined included the clinical characteristics of the
tumor and the final pathological examination of the thyroid carcinoma.
Results: PTC was diagnosed in 570 patients. Among the 61 with PTC
GD-positive, 59.0% presented with the pure papillary variant, 19.7%
with the follicular variant, 6.6% with the sclerosing variant, and
18.0% with the tall cell variant (TCV) of PTC. Among 509 PTC
GD-negative, 80.6% had pure papillary variant, 9.0% follicular
variant, 3.7% sclerosing variant, and 6.1% TCV. Patients with tumor
size >5 and 10mm demonstrated that lymph node metastasis (p=0.001) and
TCV in histological examination (p=0.003) were statistically
significantly associated with GD-positive PTC. Conclusions: The
incidence of PTC in GD-positive patients is higher than that in
GD-negative patients. Aggressive variants of PTC, such as the TCV, were
more frequent in nodular micro-PTC. These findings suggest that prompt
and meticulous evaluation of nodules in any patient with GD associated
with nodular alterations must be considered