Oxidative C(sp²)–H Phosphonation of Aldehyde Hydrazones

A K₂S₂O₈/Cu­(OAc)₂-mediated oxidative C–H/P–H cross-coupling of aldehyde hydrazones with diphenylphosphine oxide for the direct preparation of functionalized α-iminophosphine oxides is reported. The reaction shows good functional group tolerance and proceeds smoothly under mild conditions. This strategic protocol for C–P bond formation is facilitated by a net oxidative aminyl radical–polar crossover process

Copper-Mediated Direct C2-Cyanation of Indoles Using Acetonitrile as the Cyanide Source

A copper-mediated C2-cyanation of indoles using cheap and commercially available acetonitrile as the “nonmetallic” cyanide source was achieved through sequential C–C and C–H bond cleavages. The installation of a removable pyrimidyl group on the indole nitrogen atom is the key for this C2 selectivity. This approach provides a novel and alternative route leading to indole-2-carbonitrile

Cascade Photoredox/Iodide Catalysis: Access to Difluoro-γ-lactams via Aminodifluoroalkylation of Alkenes

The novel cascade photoredox/iodide catalytic system enables the alkene to serve as a radical acceptor capable of achieving aminodifluoroalkylation of alkenes. Cheap iodide salts play a vital role in this reaction, which could tune carbocation reactivity through reversible C–I bond formation for controlling reaction selectivity, and a series of competitive reactions are completely eliminated in the presence of multiple reactivity pathways. The present dual catalytic protocol affords a very convenient method for direct synthesis of various difluoro-γ-lactams from simple and readily available starting materials under mild reaction conditions

An Efficient Synthesis of Pyrrolo[2,3,4-<i>kl</i>]acridin-1-one Derivatives Catalyzed by l‑Proline

An efficient domino approach for the synthesis of novel pyrrolo[2,3,4-<i>kl</i>]acridin-1-one derivatives has been established. This reaction represents the first facile conversion of an isatin to a pyrrolo[2,3,4-<i>kl</i>]acridin-1-one via a C–N bond cleavage reaction without the need for a multistep reaction process

An Efficient Synthesis of Pyrrolo[2,3,4-<i>kl</i>]acridin-1-one Derivatives Catalyzed by l‑Proline

An efficient domino approach for the synthesis of novel pyrrolo[2,3,4-<i>kl</i>]acridin-1-one derivatives has been established. This reaction represents the first facile conversion of an isatin to a pyrrolo[2,3,4-<i>kl</i>]acridin-1-one via a C–N bond cleavage reaction without the need for a multistep reaction process

An Efficient Synthesis of Pyrrolo[2,3,4-<i>kl</i>]acridin-1-one Derivatives Catalyzed by l‑Proline

An efficient domino approach for the synthesis of novel pyrrolo[2,3,4-<i>kl</i>]acridin-1-one derivatives has been established. This reaction represents the first facile conversion of an isatin to a pyrrolo[2,3,4-<i>kl</i>]acridin-1-one via a C–N bond cleavage reaction without the need for a multistep reaction process

A Single Electron Transfer (SET) Approach to C–H Amidation of Hydrazones via Visible-Light Photoredox Catalysis

The reductive single electron transfer (SET) umpolung amination of aldehyde-derived hydrazones has been developed through visible-light-promoted photoredox catalysis. The ideal transformation of hydrazones into the corresponding hydrazonamide through selective carbon–hydrogen (C–H) bond functionalization represents one of the most step- and atom-economical methods. This SET umpolung strategy features mild conditions and a remarkably broad substrate scope, offering an entirely new substrate class to direct C–H amination

Expression of MDR1、PTEN mRNA and Protein in A2780 and A2780/DDP cells.

<p>(A) MDR1 and PTEN mRNA levels in A2780 and A2780/DDP cells. The expression of MDR1 mRNA was overexpressed in A2780/DDP compared with A2780(P<0.05), and the PTEN mRNA level showed no difference(P>0.05). (B) P-gp and PTEN protein expression levels in A2780s and A2780/DDP cells. The expression of P-gp in A2780/DDP cells was higher than that of A2780(P<0.05),and PTEN protein was at a very low levels in A2780 and A2780/DDP cells. (1,2:A2780, A2780/DDP)</p

32 differentially expressed miRNAs in A2780/DDP.

<p>32 differentially expressed miRNAs in A2780/DDP.</p

Cells inhibition by cisplatin following pre-treatment with miR-130a, -374a mimics or inhibitors.

<p>(A) The A2780 cells after transfection with miR-130a-mimic and miR-374a-mimic showed a increased ratio of surviving cells under the treatment of 0.8, 3.2 ug/ml cispaltin (*<i>p</i><0.05). (B) miR-130a-inhibitor and miR-374a-inhibitor decreased the ratio of surviving cells under the treatment of 8, 32 ug/ml cispaltin (*<i>p</i>< 0.05).</p