26 research outputs found
Oxidative C(sp<sup>2</sup>)âH Phosphonation of Aldehyde Hydrazones
A K<sub>2</sub>S<sub>2</sub>O<sub>8</sub>/CuÂ(OAc)<sub>2</sub>-mediated
oxidative CâH/PâH cross-coupling of aldehyde hydrazones
with diphenylphosphine oxide for the direct preparation of functionalized
α-iminophosphine oxides is reported. The reaction shows good
functional group tolerance and proceeds smoothly under mild conditions.
This strategic protocol for CâP bond formation is facilitated
by a net oxidative aminyl radicalâpolar crossover process
Copper-Mediated Direct C2-Cyanation of Indoles Using Acetonitrile as the Cyanide Source
A copper-mediated
C2-cyanation of indoles using cheap and commercially available acetonitrile
as the ânonmetallicâ cyanide source was achieved through
sequential CâC and CâH bond cleavages. The installation
of a removable pyrimidyl group on the indole nitrogen atom is the
key for this C2 selectivity. This approach provides a novel and alternative
route leading to indole-2-carbonitrile
Cascade Photoredox/Iodide Catalysis: Access to Difluoro-Îł-lactams via Aminodifluoroalkylation of Alkenes
The
novel cascade photoredox/iodide catalytic system enables the
alkene to serve as a radical acceptor capable of achieving aminodifluoroalkylation
of alkenes. Cheap iodide salts play a vital role in this reaction,
which could tune carbocation reactivity through reversible CâI
bond formation for controlling reaction selectivity, and a series
of competitive reactions are completely eliminated in the presence
of multiple reactivity pathways. The present dual catalytic protocol
affords a very convenient method for direct synthesis of various difluoro-Îł-lactams
from simple and readily available starting materials under mild reaction
conditions
An Efficient Synthesis of Pyrrolo[2,3,4-<i>kl</i>]acridin-1-one Derivatives Catalyzed by lâProline
An efficient domino approach for the synthesis of novel pyrrolo[2,3,4-<i>kl</i>]acridin-1-one derivatives has been established. This reaction represents the first facile conversion of an isatin to a pyrrolo[2,3,4-<i>kl</i>]acridin-1-one via a CâN bond cleavage reaction without the need for a multistep reaction process
An Efficient Synthesis of Pyrrolo[2,3,4-<i>kl</i>]acridin-1-one Derivatives Catalyzed by lâProline
An efficient domino approach for the synthesis of novel pyrrolo[2,3,4-<i>kl</i>]acridin-1-one derivatives has been established. This reaction represents the first facile conversion of an isatin to a pyrrolo[2,3,4-<i>kl</i>]acridin-1-one via a CâN bond cleavage reaction without the need for a multistep reaction process
An Efficient Synthesis of Pyrrolo[2,3,4-<i>kl</i>]acridin-1-one Derivatives Catalyzed by lâProline
An efficient domino approach for the synthesis of novel pyrrolo[2,3,4-<i>kl</i>]acridin-1-one derivatives has been established. This reaction represents the first facile conversion of an isatin to a pyrrolo[2,3,4-<i>kl</i>]acridin-1-one via a CâN bond cleavage reaction without the need for a multistep reaction process
A Single Electron Transfer (SET) Approach to CâH Amidation of Hydrazones via Visible-Light Photoredox Catalysis
The
reductive single electron transfer (SET) umpolung amination
of aldehyde-derived hydrazones has been developed through visible-light-promoted
photoredox catalysis. The ideal transformation of hydrazones into
the corresponding hydrazonamide through selective carbonâhydrogen
(CâH) bond functionalization represents one of the most step-
and atom-economical methods. This SET umpolung strategy features mild
conditions and a remarkably broad substrate scope, offering an entirely
new substrate class to direct CâH amination
Expression of MDR1ăPTEN mRNA and Protein in A2780 and A2780/DDP cells.
<p>(A) MDR1 and PTEN mRNA levels in A2780 and A2780/DDP cells. The expression of MDR1 mRNA was overexpressed in A2780/DDP compared with A2780(P<0.05), and the PTEN mRNA level showed no difference(P>0.05). (B) P-gp and PTEN protein expression levels in A2780s and A2780/DDP cells. The expression of P-gp in A2780/DDP cells was higher than that of A2780(P<0.05),and PTEN protein was at a very low levels in A2780 and A2780/DDP cells. (1,2:A2780, A2780/DDP)</p
32 differentially expressed miRNAs in A2780/DDP.
<p>32 differentially expressed miRNAs in A2780/DDP.</p
Cells inhibition by cisplatin following pre-treatment with miR-130a, -374a mimics or inhibitors.
<p>(A) The A2780 cells after transfection with miR-130a-mimic and miR-374a-mimic showed a increased ratio of surviving cells under the treatment of 0.8, 3.2 ug/ml cispaltin (*<i>p</i><0.05). (B) miR-130a-inhibitor and miR-374a-inhibitor decreased the ratio of surviving cells under the treatment of 8, 32 ug/ml cispaltin (*<i>p</i>< 0.05).</p