83 research outputs found

    Cronkhite-Canada Syndrome: A Case Report and Review of Literature

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    Cronkhite-Canada syndrome (CCS) is a rare syndrome first described in 1955. (1) Since then, 400 cases worldwide have been reported in the literature. The disease is characterized by diffuse gastrointestinal polyposis, dystrophic changes of the fingernails, alopecia, cutaneous hyperpigmentation, diarrhea, weight loss, and abdominal pain. (2) The etiology is currently unknown, but an autoimmune process is suspected. The workup is based on history and physical followed by imaging and endoscopy with biopsy to confirm gastrointestinal polyposis. The goal of treatment focuses on symptomatic management of the patient and nutritional support

    Swellable Poly N- Isopropylacrylamide Particles for Physiological Ph Sensing

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    Swellable polymers functionalized to respond to pH have been prepared from microgels of poly (N-isopropylacrylamide) copolymerized with acrylic acid, methacrylic acid, ethacrylic acid and propacrylic acid. When these N-isopropylacrylamide polymer particles are dispersed in a hydrogel, large changes occur in the turbidity of the membrane (measured by an absorbance spectrometer) as the pH of the solution in contact with the membrane is varied. Changes of approximately 0.3 absorbance units were observed in the swelling and shrinking of these pH sensitive copolymers of N-isopropylacrylamide. Swelling was nonionic as the ionic strength of the solution in contact with the copolymers was increased from 0.1M and 1.0M without a concomitant decrease in swelling. For many of the copolymers, swelling was also reversible in both low and high ionic strength pH buffered media at both ambient and physiological temperatures. Changes in the composition of the formulation used to prepare these copolymers could be correlated to their response to changes in the pH of the buffer solution in contact with them.Chemistr

    Monitoring nonenzymatic glycation of human immunoglobulin G by methylglyoxal and glyoxal: A spectroscopic study

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    The accumulation of dicarbonyl compounds, methylglyoxal (MG) and glyoxal (G), has been observed in diabetic conditions. They are formed from nonoxidative mechanisms in anaerobic glycolysis and lipid peroxidation, and they act as advanced glycation endproduct (AGE) precursors. The objective of this study was to monitor and characterize the AGE formation of human immunoglobulin G (hIgG) by MG and G using ultraviolet (UV) and fluorescence spectroscopy, circular dichroism (CD), and matrix-assisted laser desorption/ionization–mass spectrometry (MALDI–MS). hIgG was incubated over time with MG and G at different concentrations. Formation of AGE was monitored by UV and fluorescence spectroscopy. The effect of AGE formation on secondary structure of hIgG was studied by CD. Comparison of AGE profile for MG and G was performed by MALDI–MS. Both MG and G formed AGE, with MG being nearly twice as reactive as G. The combination of these techniques is a convenient method for evaluating and characterizing the AGE proteins

    Mental health outcomes among Arab refugees, immigrants, and U.S. born Arab Americans in Southeast Michigan: a cross-sectional study

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    Abstract Background Arab refugees and immigrants living in the United States may be exposed to political, economic, social, and environmental stressors that may affect their mental health. Yet, little is known regarding mental health outcomes among Arab Americans. The purpose of this study was to measure depression and anxiety levels among Arabs in Southeast Michigan and determine whether these levels differ by resident status: refugee, immigrant, or U.S. born. Methods We conducted a cross-sectional study in a convenience sample of 275 adults who self-identify as Arab living in Southeast Michigan. Participants were recruited from a non-profit health and social services organization between August–November 2015. Data were collected via self-administered questionnaires, using standardized instruments to assess depression and anxiety symptoms. Results All three resident groups exhibited high mean levels of depression and anxiety. Refugees reported higher levels of depression and anxiety than either immigrants or U.S. born Arab Americans. After adjustment for sociodemographics, differences between U.S. born Arab Americans and refugees were statistically significant for depression (b = 2.84; 95% CI: 0.21, 5.47), but not for anxiety. Refugees had significantly higher depression scores (b = 3.18, 95% CI: 1.52, 4.84) and anxiety scores (b = 1.31, 95% CI: 0.11, 2.50) than immigrants. Those reporting political violence and religious persecution as reasons for immigration had the highest levels of depression and anxiety. Conclusions This convenience sample of Arab Americans reported high levels of depression and anxiety symptoms. Refugees appear to have poorer mental health outcomes than either immigrants or U.S.-born Arab Americans.https://deepblue.lib.umich.edu/bitstream/2027.42/146724/1/12888_2018_Article_1948.pd

    Mental health outcomes among Arab refugees, immigrants, and U.S. born Arab Americans in Southeast Michigan: a cross-sectional study

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    Abstract Background Arab refugees and immigrants living in the United States may be exposed to political, economic, social, and environmental stressors that may affect their mental health. Yet, little is known regarding mental health outcomes among Arab Americans. The purpose of this study was to measure depression and anxiety levels among Arabs in Southeast Michigan and determine whether these levels differ by resident status: refugee, immigrant, or U.S. born. Methods We conducted a cross-sectional study in a convenience sample of 275 adults who self-identify as Arab living in Southeast Michigan. Participants were recruited from a non-profit health and social services organization between August–November 2015. Data were collected via self-administered questionnaires, using standardized instruments to assess depression and anxiety symptoms. Results All three resident groups exhibited high mean levels of depression and anxiety. Refugees reported higher levels of depression and anxiety than either immigrants or U.S. born Arab Americans. After adjustment for sociodemographics, differences between U.S. born Arab Americans and refugees were statistically significant for depression (b = 2.84; 95% CI: 0.21, 5.47), but not for anxiety. Refugees had significantly higher depression scores (b = 3.18, 95% CI: 1.52, 4.84) and anxiety scores (b = 1.31, 95% CI: 0.11, 2.50) than immigrants. Those reporting political violence and religious persecution as reasons for immigration had the highest levels of depression and anxiety. Conclusions This convenience sample of Arab Americans reported high levels of depression and anxiety symptoms. Refugees appear to have poorer mental health outcomes than either immigrants or U.S.-born Arab Americans
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