Information to be extracted from the included studies.

Information to be extracted from the included studies.</p

Search strategy for MEDLINE using the Ovid platform.

Search strategy for MEDLINE using the Ovid platform.</p

Additional file 1: Web-appendix 1. of Efficacy, safety and effectiveness of licensed rotavirus vaccines: a systematic review and meta-analysis for Latin America and the Caribbean

Search methods: detailed search strategy. Web-appendix 2. Criteria for trial eligibility. Web-appendix 3. Extraction sheet for trials assessing efficacy/safety and effectiveness/impact of rotavirus vaccine. Web-appendix 4. Extraction sheet for risk of bias assessment in trials evaluating efficacy/safety of rotavirus vaccine. Web-appendix 5. Selected studies for efficacy/safety evaluation of rotavirus vaccine. Web-appendix 6. Risk of bias graph. Web-appendix 7. Summary of the characteristics of studies included for assessing efficacy/safety of rotavirus vaccines. Web-appendix 8. Forest plot of meta-analysis for severe diarrhea of any cause. Web-appendix 9. Forest plot of meta-analysis for treatment-related mortality. Web-appendix 10. Forest plot of meta-analysis for treatment-related intussusception. Web-appendix 11. Common severe adverse events occurring in rotavirus immunized and placebo groups. Web-appendix 12. Forest plot of meta-analysis for treatment-related severe adverse events. Web-appendix 13. Identified studies for effectiveness evaluation of rotavirus vaccine. Web-appendix 14. Summary of the characteristics of studies included for evaluate effectivenes of rotavirus vaccine. Web-appendix 15. Summary of results of studies assessing effectiveness of rotavirus vaccine. (DOCX# 123 bytes

Search strategy for MEDLINE (Ovid).

IntroductionAdult and pediatric patients admitted to intensive care units (ICUs) requiring invasive ventilatory support, sedation, and muscle blockade may present neuromusculoskeletal deterioration. Different physical rehabilitation interventions have been studied to evaluate their effectiveness in improving critically ill patients’ outcomes. Given that many published systematic reviews (SRs) aims to determine the effectiveness of different types of physical rehabilitation interventions, it is necessary to group them systematically and assess the methodological quality of SRs to help clinicians make better evidence-based decisions. This overview of SRs (OoSRs) aims to map the existing evidence and to determine the effectiveness of physical rehabilitation interventions to improve neuromusculoskeletal function and other clinical outcomes in adult and pediatric critically ill patients.MethodsAn OoSRs of randomized and non-randomized clinical trials involving critically ill adult and pediatric patients receiving physical rehabilitation intervention will be conducted. A sensitive search of MEDLINE (Ovid), Embase (Ovid), CINAHL (EBSCOhost), Cochrane Library, Epistemonikos, and other search resources will be conducted. Two independent reviewers will conduct study selection, data extraction, and methodological quality assessment. Discrepancies will be resolved by consensus or a third reviewer. The degree of overlap of studies will be calculated using the corrected covered area. The methodological quality of the SRs will be measured using the AMSTAR-2 tool. The GRADE framework will report the certainty of evidence by selecting the "best" SR for each physical rehabilitation intervention and outcome.DiscussionThe findings of this overview are expected to determine the effectiveness and safety of physical rehabilitation interventions to improve neuromusculoskeletal function in adult and pediatric critically ill patients based on a wide selection of the best available evidence and to determine the knowledge gaps in this topic by mapping and assessing the methodological quality of published SRs.Registration numberCRD42023389672.</div

PRISMA-P 2015 checklist.

IntroductionAdult and pediatric patients admitted to intensive care units (ICUs) requiring invasive ventilatory support, sedation, and muscle blockade may present neuromusculoskeletal deterioration. Different physical rehabilitation interventions have been studied to evaluate their effectiveness in improving critically ill patients’ outcomes. Given that many published systematic reviews (SRs) aims to determine the effectiveness of different types of physical rehabilitation interventions, it is necessary to group them systematically and assess the methodological quality of SRs to help clinicians make better evidence-based decisions. This overview of SRs (OoSRs) aims to map the existing evidence and to determine the effectiveness of physical rehabilitation interventions to improve neuromusculoskeletal function and other clinical outcomes in adult and pediatric critically ill patients.MethodsAn OoSRs of randomized and non-randomized clinical trials involving critically ill adult and pediatric patients receiving physical rehabilitation intervention will be conducted. A sensitive search of MEDLINE (Ovid), Embase (Ovid), CINAHL (EBSCOhost), Cochrane Library, Epistemonikos, and other search resources will be conducted. Two independent reviewers will conduct study selection, data extraction, and methodological quality assessment. Discrepancies will be resolved by consensus or a third reviewer. The degree of overlap of studies will be calculated using the corrected covered area. The methodological quality of the SRs will be measured using the AMSTAR-2 tool. The GRADE framework will report the certainty of evidence by selecting the "best" SR for each physical rehabilitation intervention and outcome.DiscussionThe findings of this overview are expected to determine the effectiveness and safety of physical rehabilitation interventions to improve neuromusculoskeletal function in adult and pediatric critically ill patients based on a wide selection of the best available evidence and to determine the knowledge gaps in this topic by mapping and assessing the methodological quality of published SRs.Registration numberCRD42023389672.</div

Data extraction.

IntroductionAdult and pediatric patients admitted to intensive care units (ICUs) requiring invasive ventilatory support, sedation, and muscle blockade may present neuromusculoskeletal deterioration. Different physical rehabilitation interventions have been studied to evaluate their effectiveness in improving critically ill patients’ outcomes. Given that many published systematic reviews (SRs) aims to determine the effectiveness of different types of physical rehabilitation interventions, it is necessary to group them systematically and assess the methodological quality of SRs to help clinicians make better evidence-based decisions. This overview of SRs (OoSRs) aims to map the existing evidence and to determine the effectiveness of physical rehabilitation interventions to improve neuromusculoskeletal function and other clinical outcomes in adult and pediatric critically ill patients.MethodsAn OoSRs of randomized and non-randomized clinical trials involving critically ill adult and pediatric patients receiving physical rehabilitation intervention will be conducted. A sensitive search of MEDLINE (Ovid), Embase (Ovid), CINAHL (EBSCOhost), Cochrane Library, Epistemonikos, and other search resources will be conducted. Two independent reviewers will conduct study selection, data extraction, and methodological quality assessment. Discrepancies will be resolved by consensus or a third reviewer. The degree of overlap of studies will be calculated using the corrected covered area. The methodological quality of the SRs will be measured using the AMSTAR-2 tool. The GRADE framework will report the certainty of evidence by selecting the "best" SR for each physical rehabilitation intervention and outcome.DiscussionThe findings of this overview are expected to determine the effectiveness and safety of physical rehabilitation interventions to improve neuromusculoskeletal function in adult and pediatric critically ill patients based on a wide selection of the best available evidence and to determine the knowledge gaps in this topic by mapping and assessing the methodological quality of published SRs.Registration numberCRD42023389672.</div

Prevalence, awareness, treatment and control of diabetes and impaired fasting glucose in the Southern Cone of Latin America

<div><p>Aims</p><p>To determine the prevalence, treatment and control of diabetes mellitus (DM) and impaired fasting glucose (IFG) as well as associated factors in the adult population of four cities of the Southern Cone of Latin America (SCLA).</p><p>Methods</p><p>This is a cross-sectional population-based study that included 7407 adults between 35 and 74 years old in four cities of the SCLA: Temuco (Chile), Marcos Paz and Bariloche (Argentina), and Pando-Barros Blancos (Uruguay). DM was defined as fasting plasma glucose ≥126 mg/dL or self-reported history of diabetes. Awareness, treatment, and control of DM were defined as subjects self-reporting a DM previous diagnosis, the use of a prescription medication or nonpharmacological intervention for DM, and fasting plasma glucose <126 mg/dl, respectively.</p><p>Results</p><p>Prevalence of DM varied among cities, between 8.4% in Bariloche and 14.3% in Temuco. Prevalence of IFG varied at different sites, from 3.5% in Barros Blancos to 6.8% in Marcos Paz. Of the total number of people with diabetes, 20% were newly diagnosed at the time of the study. Overall, 79.8% of patients with diabetes were aware of their condition. The treatment and control rate were 58.8% and 46.2%, respectively. Older age, family history of diabetes, lower educational attainment, overweight, obesity, central obesity, low physical activity, hypertension, hypercholesterolemia and hypertriglyceridemia were all significantly associated with an increased risk of diabetes.</p><p>Conclusions</p><p>The prevalence of DM and IFG in the adult population of the SCLA is high and varies among cities. These conditions represent a public health challenge since the rates of awareness, treatment, and control are still low.</p></div

Multivariate odds ratios (ORs) and 95% confidence intervals (95% CIs) for the association of risk factors with Obesity and Central Obesity among adults aged 35–74 years in the Southern Cone of Latin America.

<p>Multivariate odds ratios (ORs) and 95% confidence intervals (95% CIs) for the association of risk factors with Obesity and Central Obesity among adults aged 35–74 years in the Southern Cone of Latin America.</p

Awareness, treatment and control of diabetes among adults aged 35–74 years in the Southern Cone of Latin America.

<p>Awareness, treatment and control of diabetes among adults aged 35–74 years in the Southern Cone of Latin America.</p

Estimated prevalence of impaired fasting glucose and diabetes among adults aged 35–74 years in the Southern Cone of Latin America.

<p>Estimated prevalence of impaired fasting glucose and diabetes among adults aged 35–74 years in the Southern Cone of Latin America.</p