Body measurements, blood biochemistry and blood pressure measurements in offspring by parental group.

<p>Box-and-whiskers plots show median and IQR (‘<b>+’</b> within the box denotes mean value) for the OMD (white boxes), OFD (hatched boxes) and ONoPD (grey boxes) in males (left) and females (right); box-and whiskers for rest of cohort (RoC, i.e. all those without diabetes excluded from the F₁-offspring groups, [black boxes] for males and females) are also shown for comparison. Graphs are shown for Waist (A), HDL-cholesterol (B), Glucose (C), Systolic-blood pressure (D), Diastolic-blood pressure (E), BMI (F) and Percent body-fat (G). Groups were compared by Kruskal-Wallis, with level of significance between the groups indicated (* P<0.05, **P<0.01, *** P<0.001, **** P<0.0001).</p

Phenotypic correlations of MDD status (absent = 0, affected = 1) between kinship dyads.

<p>Estimates from 500 jack-knifed replicates that sampled a single pair from each family for full siblings (N families with one or more pairs = 4306), full sisters (N = 2239), full brothers (N = 1161), opposite sex full-siblings (N = 2426), parent-child (N = 3402), grandparent-grandchild (N = 391), avuncular (aunt/uncle-niece/nephew N = 1826), first cousins (N = 1194).</p

Heritability, variance proportions, and stratified correlations of MDD.

<p>h² = heritability, r_G = genetic correlation, c² = shared family environment, r_C = shared family environment correlation.</p

The effects of social and demographic variables on MDD risk.

<p>The effects of social and demographic variables on MDD risk.</p

Sociodemographic comparison of GS:SFHS and the Scottish population.

<p>* People aged 16–74 years</p><p>^a Scottish Executive (2012)</p><p>^b Scottish Executive (2006)</p><p>Sociodemographic comparison of GS:SFHS and the Scottish population.</p

Age of onset distribution.

<p>Dashed line is the mean.</p

Kaplan-Meier survival curves for age of onset by age group.

<p>Kaplan-Meier survival curves for age of onset by age group.</p

Number of informative relationships for MDD and AOO pedigree analysis in GS:SFHS.

<p>Number of informative relationships for MDD and AOO pedigree analysis in GS:SFHS.</p