Descriptive characteristics of genotyped adolescents and adults stratified by sex.

<p>Descriptive characteristics of genotyped adolescents and adults stratified by sex.</p

Quantile-quantile plot of observed against expected heterogeneity P-value for allelic associations with triglycerides.

<p>The grey shaded area represents the 95% confidence interval.</p

Quantile-quantile plot of observed against expected heterogeneity P-value for allelic associations with LDL-C.

<p>The grey shaded area represents the 95% confidence interval.</p

Loci exhibiting adult-adolescent heterogeneity at p<0.05. The locus/phenotype combinations tested were based on the significant associations reported for adults by Teslovich et al.

<p>“Allele/MAF” listed are: major allele, minor allele frequency (MAF). Numbers in “Beta” columns are in SD units, modelled as additive effect of the reference allele.</p

Quantile-quantile plot of observed against expected heterogeneity P-value for allelic associations with HDL-C.

<p>The grey shaded area represents the 95% confidence interval.</p

Quantile-Quantile plot showing the association between the observed and expected −log10 p-values.

<p>The grey shade area represents the 95% confidence interval. The plot shows the results of the combined study design.</p

Descriptive statistics for antisocial personality disorder (ASPD) and antisocial behavior (ASB).

<p>Descriptive statistics for antisocial personality disorder (ASPD) and antisocial behavior (ASB).</p

Manhattan plot showing the GWAS results of the combined study design for adult antisocial behavior.

<p>X-axis represents the chromosomal location for each SNP, and y-axis the −log10 p-value of the association signal.</p

Logistic regressions on the associations of the <i>DRD3</i> variant rs2399496 and nicotine dependence (ND) with major depressive disorder (MDD): Models combining the ND (no/yes) and rs2399496 (TT = 0, TA = 1, or AA = 2 minor alleles) status.

a<p>Adjusted for sex, age, and alcohol abuse.</p

Association analyses results (p-values) for <i>DRD3</i> SNPs.

<p>DSM-IV, Diagnostic and Statistical Manual of Mental Disorders, 4^th edition (APA 1994); MDD, major depressive disorder; ND, nicotine dependence.</p>a<p>, significant p-value (study-specific threshold p<0.00042).</p>b<p>, suggestive p-value (study-specific threshold 0.00042</p