Impact of distraction and memory on grammaticality judgment in a patient with aphasia

The relationship between cognitive and linguistic performance by patients with aphasia is an area of ongoing study. Attention and short term memory may exert greater influence over linguistic performance than structural deficits.  Grammaticality judgment is one way of examining sentence processing in both normal individuals and persons with aphasia, who often demonstrate GJ skills that exceed their sentence comprehensions skills.  This study sought to explore the relationships between attention and short term memory in a GJ task in distraction by comparing the performance of a patient with aphasia to that of normal older adults

Local cytokine transcription in naïve and previously infected sheep and lambs following challenge with Teladorsagia circumcincta

<b>Background</b><p></p> The abomasal helminth Teladorsagia circumcincta is one of the most economically important parasites affecting sheep in temperate regions. Infection is particularly detrimental to lambs, in which it can cause pronounced morbidity and severe production losses. Due to the spreading resistance of this parasite to all classes of anthelmintic drugs, teladorsagiosis is having an increasingly severe impact on the sheep industry with significant implications for sheep welfare. Protective immunity develops slowly, wanes rapidly and does not appear to be as effective in young lambs. To investigate the development of immunity to T. circumcincta in sheep and lambs, we used cytokine transcript profiling to examine differences in the abomasal mucosa and gastric lymph node of naïve and previously infected sheep and lambs following challenge.<p></p> <b>Results</b><p></p> The results of these experiments demonstrated that the abomasal mucosa is a major source of cytokines during abomasal helminth infection. A local Th2-type cytokine response was observed in the abomasal mucosa and gastric lymph node of the previously infected sheep and lambs when compared with those of the naïve during the early stages of infection. In contrast, a pro-inflammatory component more was evident in the abomasal mucosa and gastric lymph node of the naïve sheep when compared with those of the previously infected, which was not observed in the lambs.<p></p> <b>Conclusions</b><p></p> The greater levels of Th2-type cytokine transcripts in both the abomasum and gastric lymph node of the previously infected compared with naïve sheep and lambs emphasises the importance of these mechanisms in the immune response to T. circumcincta infection. Younger lambs appear to be able to generate similar Th2-type responses in the abomasum suggesting that the increased morbidity and apparent lack of resistance in younger lambs following continuous or repeated exposure to T. circumcincta is unlikely to be due to a lack of appropriate Th2-type cytokine production

A comprehensive survey of Douglas Lake, Cheboygan County, MI.

Without knowledge of the natural state of a lake at a given degree of productivity and a profile of its features, it is at best difficult to define what the goal of lake and watershed conservation/management for a lake at that state of development should be. With the objective of developing a full profile of Douglas Lake, Cheboygan County, Michigan, a comprehensive survey was undertaken. The morphometric parameters investigated were a) the method of basin formation, b) morphometry of the lake basin and littoral zone, c) geology underlying the lake basin and watershed, d) underlying soils of the watershed, e) area of the watershed, and f) watershed land use patterns. Physical parameters measured in Douglas Lake included a) depth, b) temperature and summer thermal stratification, c) depth-dependent light intensity, d) conductivity, e) oxygenation, f) chlorophyll a levels, g) alkalinity/hardness, and h) concentrations of nitrogen, phosphorous, and silica (nutrient richness) by strata. Biotic parameters were surveyed by measuring a) the abundance and diversity of non-benthic phytoplankton, b) abundance and diversity of non-benthic zooplanktoon, c) diversity of littoral zone macroinvertebrates, and d) diversity of littoral zone macrophytes. The goal of the survey was to measure the basic morphometric, physical, and biotic parameters of Douglas Lake, analyze the surveyed measurements for their individual indications of trophic status, and ultimately integrate all measurements and analyses to create a picture of the lake's overall productivity. Leeches are usually found under sticks or stones or in the mud on the bottom of lakes, ponds, and streams unless actively in search of food. Of approximately three hundred leeches collected in the Douglas Lake region during June and July, none were found at a depth greater than two feet. The temperature range of the water was between 18 C and 26 C. Gently moving water in protected coves or at the outlets or inlets of lakes is preferred to still water.http://deepblue.lib.umich.edu/bitstream/2027.42/54731/1/3172.pd

Global Outsourcing of Healthcare: A Medical Tourism Decision Model

The demand for global healthcare services is experiencing tremendous growth. US patients are seeking to reduce their expenditures on healthcare through obtaining treatment on an internationally competitive basis. This trend, known as medical tourism, is on the rise, and US legislators and policy makes must be aware of the issues facing American patients. This paper seeks to model factors that influence a patient's decision to seek healthcare services abroad. we develop a two-stage model for medical tourism- the first stage being the evaluation of the foreign country and the second stage choosing the healthcare facility. We argue country-specific characteristics influence the country of choice-including economic condition, political climate, and regulatory policies. We also argue that certain factors- including costs, hospital accreditaion, quality of care, and physician trining- impact the choice of healthcare facility. The model suggests that no one factor is dominant in the decision, but all play a crucial role in choosing healthcare on an international basis. Policy makers must use these factors to evaluate the impact medical tourism will continuw to have on the US healtcare system in order to effectively compete in today's global, consumer-driven healthcare market.Medical tourism; global outsourcing; decision model; health care system; healthcare services; health policy; health costs

Non-equilibrium dynamics and floral trait interactions shape extant angiosperm diversity.

Why are some traits and trait combinations exceptionally common across the tree of life, whereas others are vanishingly rare? The distribution of trait diversity across a clade at any time depends on the ancestral state of the clade, the rate at which new phenotypes evolve, the differences in speciation and extinction rates across lineages, and whether an equilibrium has been reached. Here we examine the role of transition rates, differential diversification (speciation minus extinction) and non-equilibrium dynamics on the evolutionary history of angiosperms, a clade well known for the abundance of some trait combinations and the rarity of others. Our analysis reveals that three character states (corolla present, bilateral symmetry, reduced stamen number) act synergistically as a key innovation, doubling diversification rates for lineages in which this combination occurs. However, this combination is currently less common than predicted at equilibrium because the individual characters evolve infrequently. Simulations suggest that angiosperms will remain far from the equilibrium frequencies of character states well into the future. Such non-equilibrium dynamics may be common when major innovations evolve rarely, allowing lineages with ancestral forms to persist, and even outnumber those with diversification-enhancing states, for tens of millions of years

Emerging Pattern of Rabies Deaths and Increased Viral Infectivity

Most human rabies deaths in the United States can be attributed to unrecognized exposures to rabies viruses associated with bats, particularly those associated with two infrequently encountered bat species (Lasionycteris noctivagans and Pipistrellus subflavus). These human rabies cases tend to cluster in the southeastern and northwestern United States. In these regions, most rabies deaths associated with bats in nonhuman terrestrial mammals are also associated with virus variants specific to these two bat species rather than more common bat species; outside of these regions, more common bat rabies viruses contribute to most transmissions. The preponderance of rabies deaths connected with the two uncommon L. noctivagans and P. subflavus bat rabies viruses is best explained by their evolution of increased viral infectivity

Reviews

The following publications have been reviewed by the mentioned authors;Beginning Graphical Communication by M. Jordan, B. Hawtin and A. Neil, reviewed by John LeesArt Related Topics by Bob Nunn and Chris Locke, reviewed by A. CharltonHandbook for Art and Design Students by Robin Jesson, reviewed by John LancasterDrawing and Cognition Descriptive and Experimental Studies of Graphic Production Processes by Peter Van Sommers, reviewed by Pamela M. SchenkThe Student's Guide to Western Calligraphy an Illustrated Survey by Joyce Irene Whalley, reviewed by John LancasterSource Directory for Authentic Indian, Eskimo and Aleut Arts and Crafts by the Indian Arts and Crafts BoardMarianne Straub by Mary Schoeser, reviewed by Kim GreerMisha Black by Avril Blake, reviewed by Kim Greer'Working in Crafts' - A National Survey by the Crafts Council, reviewed by L. SayerDirectory of Design Expertise by the Design Council, reviewed by R. Smit

Takayasu arteritis presenting as cerebral aneurysms in an 18 month old: A case report

<p>Abstract</p> <p>Background</p> <p>Central nervous system involvement occurs in as many as twenty percent of Takayasu arteritis cases. When central nervous system disease is present, it typically manifests as cerebral ischemia or stroke. There are rare reports of intracranial aneurysms in adults with Takayasu arteritis, but none in children.</p> <p>Case presentation</p> <p>We describe a case of Takayasu arteritis in an 18 month old girl who presented with a ruptured cerebral aneurysm. Full body magnetic resonance angiography revealed bilateral iliac, pelvic and intragluteal aneurysms, irregular terminal aorta, and stenotic renal arteries. Iliac vessel biopsy showed a lymphocytic infiltrate and giant cells localized to the internal elastica.</p> <p>Conclusion</p> <p>This case highlights cerebral aneurysm as a highly unusual initial manifestation of Takayasu arteritis and demonstrates the challenges of diagnosis, treatment, and assessment of response to therapy in TA in children.</p

Expression of three intelectins in sheep and response to a Th2 environment

Sheep intelectin1 and sheep intelectin3 (sITLN1 and sITLN3) were cloned and sequenced. The amino acid sequences of sITLN1 and sITLN3 shared 86% and 91% homology with the previously cloned sheep intelectin2 (sITLN2), respectively. Expression of sITLN1 and sITLN3 transcript was demonstrated in abomasum, lung, colon and gastric lymph node, terminal rectum, skin, jejunum, mesenteric lymph node, ileal peyer’s patches, brain, kidney, liver, spleen, skin, ear pinna, heart and ovary in normal sheep tissues. sITLN2 transcript expression was restricted to the abomasal mucosa in normal sheep tissues. Using a non selective chicken anti-intelectin antibody, tissue intelectin protein was demonstrated in mucus neck cells in the abomasum, mucus cells in the colon, free mucus in ileum, goblet cells in the lung, small intestinal epithelium and brush border, epidermal layer of the skin and skin sebaceous glands. The expression of the three sITLN transcripts was examined in two nematode infections in sheep known to induce a Th2 response; a Teladorsagia circumcincta challenge infection model and a Dictyocaulus filaria natural infection. The three sITLN were absent in unchallenged naïve lambs and present in the abomasal mucosa of both naïve and immune lambs following T. circumcincta challenge infection. Upregulation of sITLN2 and sITLN3 was shown in sheep lung following D. filaria natural infection. Intelectins may play an important role in the mucosal response to nematode infections in ruminants