Traumi infantili, intelligenza emotiva e regolazione delle emozioni in un campione di autori di reati sessuali

The aim of the following study is to examine in the Italian context, the prevalence of adverse childhood experience in a sample of detainee sexual offenders, and their correlation with risk of recidivism, emotional intelligence and emotion regulation. The sample is composed by 32 inmates. For the study the following instruments were used: ACE, DERS-16, TMMS and RM2000. The results show high presence of childhood traumas between sex offenders, and a strong correlation between adverse experiences and a higher risk of recidivism, a lower emotional intelligence and more difficulties in the regulation of bad emotions. Clinical consideration about treatment of sex offender are discussed.L’obiettivo del presente studio è quello di analizzare nel contesto italiano, la prevalenza di traumi infantili in un campione di autori di reati sessuali e indagare quale relazione intercorra tra i pregressi traumi infantili, il rischio di recidiva, l’intelligenza emotiva e la regolazione delle emozioni. Il campione è costituito da 32 soggetti detenuti. Per le rilevazioni sono stati usati i seguenti strumenti: ACE, DERS-16, TMMS e RM2000. Le analisi statistiche mostrano una significativa presenza di traumi infantili e evidenziano una forte correlazione tra questi, il rischio di recidiva, l’intelligenza emotiva e la capacità di gestione delle emozioni negative. Infine, sono discusse alcune implicazioni relative al trattamento conseguenti ai risultati ottenuti

Clinical and Clinico-Pathological Observations of the Erythrocyte Sedimentation Rate in Dogs Affected by Leishmaniosis and Other Inflammatory Diseases

The erythrocyte sedimentation rate (ESR) has been used in canine medicine in several disorders, above all, to evaluate levels of inflammation. This study evaluated the ESR in canine leishmaniosis (CanL) and other inflammatory conditions. Three groups of dogs were examined: CanL affected dogs without clinical signs (INFECTED group, #25) or with clinical signs (SICK group, #43) and dogs affected by acute or acute-on-chronic conditions (OTHER DISEASE group, #65). The ESR was compared with acute phase proteins or reactants either positive or negative (leukogram, fibrinogen, iron, unsaturated iron binding capacity, ferritin, haptoglobin, and albumin) and immunological markers (gamma-globulins, IgG, and IgM). The ESR was higher in the SICK group than in the INFECTED group (median 39 vs. 11 mm/h; p 0.05). The extent of changes in ESR can help to establish the severity of CanL and other inflammatory disorders. As a point-of-care test, the ESR can be used to screen dogs for unhealthy conditions, and its values correlate with the severity of any disease, including CanL

Chronic cholesterol administration to the brain supports complete and long-lasting cognitive and motor amelioration in Huntington's disease

: Evidence that Huntington's disease (HD) is characterized by impaired cholesterol biosynthesis in the brain has led to strategies to increase its level in the brain of the rapidly progressing R6/2 mouse model, with a positive therapeutic outcome. Here we tested the long-term efficacy of chronic administration of cholesterol to the brain of the slowly progressing zQ175DN knock-in HD mice in preventing ("early treatment") or reversing ("late treatment") HD symptoms. To do this we used the most advanced formulation of cholesterol loaded brain-permeable nanoparticles (NPs), termed hybrid-g7-NPs-chol, which were injected intraperitoneally. We show that one cycle of treatment with hybrid-g7-NPs-chol, administered in the presymptomatic ("early treatment") or symptomatic ("late treatment") stages is sufficient to normalize cognitive defects up to 5 months, as well as to improve other behavioral and neuropathological parameters. A multiple cycle treatment combining both early and late treatments ("2 cycle treatment") lasting 6 months generates therapeutic effects for more than 11 months, without severe adverse reactions. Sustained cholesterol delivery to the brain of zQ175DN mice also reduces mutant Huntingtin aggregates in both the striatum and cortex and completely normalizes synaptic communication in the striatal medium spiny neurons compared to saline-treated HD mice. Furthermore, through a meta-analysis of published and current data, we demonstrated the power of hybrid-g7-NPs-chol and other strategies able to increase brain cholesterol biosynthesis, to reverse cognitive decline and counteract the formation of mutant Huntingtin aggregates. These results demonstrate that cholesterol delivery via brain-permeable NPs is a therapeutic option to sustainably reverse HD-related behavioral decline and neuropathological signs over time, highlighting the therapeutic potential of cholesterol-based strategies in HD patients. DATA AVAILABILITY: This study does not include data deposited in public repositories. Data are available on request to the corresponding authors

LA GEOMETRIA E LA PITTURA DELLE VOLTE AD OMBRELLO: CAMERA DI SAN PAOLO E PALAZZETTO S. VITALE A PARMA

Dal segno al simbolo: la geometia delle superfici voltate La geometria e la pittura delle volte ad ombrello: Camera di S. Paolo e Palazzetto Eucherio S. Vitale a Parma. Ilaria Fioretti, Maria Evelina Melley, Daniela Paltrinieri La volta ad ombrello è nella realtà una volta a crociera su base poligonale, erroneamente denominata ad “ombrello” per il sistema di archi diametrali dai quali è costituita. Si propone di approfondire la genesi e conformazione geometrica di queste volte molto particolari, nonchè indagare ed analizzare il loro apparato pittorico con il quale sono decorate. Il rapporto struttura ed ornamento e/o decoro appare assai interessante proprio per la conformazione a spicchi di tali strutture. Analizzando la conformazione geometrica delle volte composte (a raggiera, a ventaglio) quelle ad ombrello hanno come loro genesi geometrica la cupola ed appartengono alle superfici quadriche, che si caratterizzano per avere come direttrici e generatrici delle coniche non degeneri. Il loro utilizzo quale sistema di copertura di particolari ambienti, già presente nell’architettura gotica, si evolve anche in quella successiva, lasciandoci numerosi esempi. Nello specifico del contributo si analizzano due esempi significativi di volta ad ombrello: quella presente nel complesso di San Paolo e quelle poste a coperture di alcuni vani nel Palazzetto Eucherio S. Vitale a Parma

Laparoscopic combined Nissen-Rossetti fundoplication and cholecystectomy: our experience - [Plastica Nissen-Rossetti e colecistectomia in un unico tempo laparoscopico: esperienza personale]

The aim of this study is to valuate the opportunity to associate both laparoscopic Nissen-Rossetti fundoplication and cholecystectomy in patients with gallbladder cholelithiasis and gastro-oesophageal acid reflux (endoscopically and pHmetrically assessed), considerating that the gallbladder removal makes duodenal-gastric reflux worse. From 2005 until 2007 we associated laparoscopic Nissen-Rossetti fundoplication and cholecystectomy in 10 patiens, who presented surgical indications for gallbladder cholelithiasis and gastro-oesophageal reflux. Clinical data, surgical procedures and post-operative complications were compared to our esperiency on the singular procedure (laparoscopic Nissen-Rossetti fundoplication and cholecystectomy). Results were valuated at 3, 6 and 12 months after surgical interventions by clinical and instrumental follow up (24-pH-metry and oesophagus-gastro-duodenoscopy). The analysis of instrumental data of these associated procedures doesn't present significative differences between the singular surgical approach. In all the patients treated by combined procedure, the follow-up shows a normal pHmetric exam, a good control on the acid reflux by fundosplication, absence of distal oesophagitis and gastric reflux symptoms. The association of laparoscopic Nissen-Rossetti fundoplication and laparoscopic cholecystectomy is indicated in patients who present both pathologies and needs to be considerating in relations to the good results and the low postoperatoric morbidity

24H pHmetric Evaluation of GERD after Laparoscopic Nissen-Rossetti Fundoplication: 1 Year Follow Up. 21st National Congress of the Italian Polyspecialist Society of Young Surgeons (IPSYS). June 15-18, 2008, Perugia

Introduction: Laparoscopic Nissen Fundoplication is the gold standard for surgical treatment of GERD. Results 1 year after Nissen-Rossetti Fundoplication is reported. Material and Methods: 92 N-R performed, underwent to a pre and postoperative work-up including symptom quest, barium meal, endoscopy and 24-h pH-metry. 64 patients were considered. 92% of treated patients was asymptomatic. Results: 24-h pH-metry was positive in 3 cases: total number of reflux episodes decreased from 40,00 ± 4,5 to 8,79 ± 2,3; the duration of longest episode decreased from 98,73 mins to 11,50 mins; the percentage of time with esophageal pH<4 was 1,8% ± 0,7 for total time, 1,4% ± 1,3 for supine time and 1,88% ± 0,6 for erect time; DeMeester & Johnson’s Score decreased from 79,4 ± 1,0 to 13,2 ± 3,1; endoscopy with histological samples evidenced a strong improvement of esophagitis, a stationary aspect of Barrett’s Esophagus in 1 patients, a complete regression in 2 patients; 17 patients complained dysphagia spontaneously relieved within 1 month; there was no need of reintervention, only one patient recurred to PPI therapy and one to benzodiazepine administration, however 95% of patients were completely satisfied by surgical results. Conclusion: Based on our personal experience, laparoscopic N-R Fundoplication can totally control acid reflux after 1 year with relatively few complications and a high degree of patient satisfaction