SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination

BACKGROUND: Most studies of immunity to SARS-CoV-2 focus on circulating antibody, giving limited insights into mucosal defences that prevent viral replication and onward transmission. We studied nasal and plasma antibody responses one year after hospitalisation for COVID-19, including a period when SARS-CoV-2 vaccination was introduced. METHODS: In this follow up study, plasma and nasosorption samples were prospectively collected from 446 adults hospitalised for COVID-19 between February 2020 and March 2021 via the ISARIC4C and PHOSP-COVID consortia. IgA and IgG responses to NP and S of ancestral SARS-CoV-2, Delta and Omicron (BA.1) variants were measured by electrochemiluminescence and compared with plasma neutralisation data. FINDINGS: Strong and consistent nasal anti-NP and anti-S IgA responses were demonstrated, which remained elevated for nine months (p < 0.0001). Nasal and plasma anti-S IgG remained elevated for at least 12 months (p < 0.0001) with plasma neutralising titres that were raised against all variants compared to controls (p < 0.0001). Of 323 with complete data, 307 were vaccinated between 6 and 12 months; coinciding with rises in nasal and plasma IgA and IgG anti-S titres for all SARS-CoV-2 variants, although the change in nasal IgA was minimal (1.46-fold change after 10 months, p = 0.011) and the median remained below the positive threshold determined by pre-pandemic controls. Samples 12 months after admission showed no association between nasal IgA and plasma IgG anti-S responses (R = 0.05, p = 0.18), indicating that nasal IgA responses are distinct from those in plasma and minimally boosted by vaccination. INTERPRETATION: The decline in nasal IgA responses 9 months after infection and minimal impact of subsequent vaccination may explain the lack of long-lasting nasal defence against reinfection and the limited effects of vaccination on transmission. These findings highlight the need to develop vaccines that enhance nasal immunity. FUNDING: This study has been supported by ISARIC4C and PHOSP-COVID consortia. ISARIC4C is supported by grants from the National Institute for Health and Care Research and the Medical Research Council. Liverpool Experimental Cancer Medicine Centre provided infrastructure support for this research. The PHOSP-COVD study is jointly funded by UK Research and Innovation and National Institute of Health and Care Research. The funders were not involved in the study design, interpretation of data or the writing of this manuscript

A century of trends in adult human height

Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.5-22.7) and 16.5 cm (13.3-19.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8-144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries

An early Permian brachiopod–gastropod fauna from the Calytrix Formation, Barbwire Terrace, Canning Basin, Western Australia

A small brachiopod&ndash;gastropod fauna from a core close to the base of the Calytrix Formation within the Grant Group includes the brachiopods Altiplecus decipiens (Hosking), Myodelthyrium dickinsi (Thomas), Brachythyrinella narsarhensis (Reed), Neochonetes (Sommeriella) obrieni Archbold, Tivertonia barbwirensis sp. nov. and the gastropod Peruvispira canningensis sp. nov. The fauna has affinities with that of the late Sakmarian‒early Artinskian Nura Nura Member directly overlying the Grant Group in other parts of the basin but, as with all lower Cisuralian (and Pennsylvanian) glacial strata in Western Australia, its precise age remains poorly constrained, especially in terms of correlation to international stages. Although the Calytrix fauna lies within the Pseudoreticulatispora confluens Palynozone, the only real constraint on its age (and that of the associated glacially influenced strata) is from Sakmarian (Sterlitamakian) and stratigraphically younger faunas. A brief review of radiometric ages from correlative strata elsewhere in Gondwana shows that those ages need to be updated. The presence of Asselian strata and the position of the Carboniferous‒Permian boundary remain unclear in Western Australia.Arturo C&eacute;sar Taboada [[email protected]], CONICET-Laboratorio de Investigaciones en Evoluci&oacute;n y Biodiversidad (LIEB), Facultad de Ciencias Naturales, Sede Esquel, Universidad Nacional de la Patagonia &lsquo;San Juan Bosco&rsquo;, Edificio de Aulas, Ruta Nacional 259, km. 16,5, Esquel U9200, Chubut, Argentina; Arthur Mory [[email protected]], Geological Survey of Western Australia, 100 Plain Street, East Perth, WA 6004, School of Earth and Environment, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia; Guang R. Shi [[email protected]], School of Life and Environmental Sciences, Deakin University, Melbourne Burwood Campus, 221 Burwood Highway, Burwood, Victoria 3125, Australia; David W. Haig [[email protected]], School of Earth and Environment (M004), The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia; Mar&iacute;a Karina Pinilla [[email protected]], Divisi&oacute;n Paleozoolog&iacute;a Invertebrados, Museo de Ciencias Naturales de La Plata, Paseo del Bosque s/n, 1900 La Plata, Buenos Aires, Argentina