In vitro evaluation of preabsorptive events of dispersed supramolecular aggregates by dynamic light scattering : Oral multivitamins as a model case

In order to develop an approach to evaluate the preabsorptive behavior of supramolecular aggregate carriers, three commercial oral formulations of a mixture of lipophilic and hydrophilic vitamins dispersed in water-glycerin-polysorbate-80 (PS-80) vehicle were subjected to dynamic light scattering and electrokinetic determinations. They exhibited diffusion coefficients ranging from 4.46 .10-9 to 3.22 .10-8 cm2/s. To mimic in vivo environment the formulations were progressively diluted with water and simulated gastric and intestinal fluids until a ratio 1:10. Hydrodynamic diameters (dH) at 37 °C and electrokinetic potentials of each formulation remained almost unchanged in the three assayed conditions. However, the average dH were 1.00, 1.36 and 1.63 times higher than a reference dispersion of PS-80 revealing significant differences among formulations. Concentration of PS-80 in diluted samples is about 103 times above its critical micellar concentration. Therefore, loaded core/shell micelles appears to be robust drug carriers that will interact with the gastrointestinal membranes upon administration. The observed differences in size and/or shape would be related to the biopharmaceutical performance of multisource products. Besides, the developed approach could be used in developing and control stages of such pharmaceutical systems.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Data from an International Multi-Centre Study of Statistics and Mathematics Anxieties and Related Variables in University Students (the SMARVUS Dataset)

This large, international dataset contains survey responses from N = 12,570 students from 100 universities in 35 countries, collected in 21 languages. We measured anxieties (statistics, mathematics, test, trait, social interaction, performance, creativity, intolerance of uncertainty, and fear of negative evaluation), self-efficacy, persistence, and the cognitive reflection test, and collected demographics, previous mathematics grades, self-reported and official statistics grades, and statistics module details. Data reuse potential is broad, including testing links between anxieties and statistics/mathematics education factors, and examining instruments’ psychometric properties across different languages and contexts. Data and metadata are stored on the Open Science Framework website (https://osf.io/mhg94/)