Copolar Calibration of Multistatic Radar in the Presence of Multipath

This paper addresses the Polarimetrie calibration of the nodes of a multistatic radar system, by using a reference object with known scattering matrix, such as a metallic sphere. A calibration technique is proposed and its experimental validation performed in a realistic scenario, by accounting also for the multipath effect. The intensity of the signal scattered by a metallic sphere and received by the monostatic and bistatic nodes of the NetRAD system is measured, by varying the antenna height, the object range and the bistatic angle. The adopted calibration technique shows a quite good accuracy, as the calibrated values of the radar cross section of the reference object are close to the theoretical ones, after the compensation of the multipath effect

Correlation Analysis of Simultaneously Collected Bistatic and Monostatic Sea Clutter

In this work we analyse the correlation properties of simultaneous bistatic and monostatic polarimetric sea clutter data, collected by the NetRAD multistatic radar system. In particular, we study the temporal autocorrelation and cross-correlation functions of the texture and speckle samples, as a function of the system geometry and of the polarization of the transmitter and receiver antennas. These features can vary significantly as a function of bistatic angle and the goal of this paper is to quantify these variations and extract any trends that are observed

Measurements of multistatic X&L band radar signatures of UAVs

This paper illustrates the results of a series of measurements of multistatic radar signatures of small UAVs at L and X band. The system employed was the multistatic multiband radar system, NeXtRAD, consisting of one monostatic transmitter-receiver and two bistatic receivers. Results demonstrate the capability of the system of recording bistatic data with baselines and two-way bistatic range of the order of few kilometres

Measurements and discrimination of drones and birds with a multi‐frequency multistatic radar system

This article presents the results of a series of measurements of multistatic radar signatures of small UAVs at L‐ and X‐bands. The system employed was the multistatic multiband radar system, NeXtRAD, consisting of one monostatic transmitter‐receiver and two bistatic receivers. NeXtRAD is capable of recording simultaneous bistatic and monostatic data with baselines and two‐way bistatic range of the order of a few kilometres. The paper presents an empirical analysis with range‐time plots and micro‐Doppler signatures of UAVs and birds of opportunity recorded at several hundred metres of distance. A quantitative analysis of the overall signal‐to‐noise ratio is presented along with a comparison between the power of the signal scattered from the drone body and blades. A simple study with empirically obtained features and four supervised‐learning classifiers for binary drone versus non‐drone separation is also presented. The results are encouraging with classification accuracy consistently above 90% using very simple features and classification algorithms

Contact-force monitoring increases accuracy of right ventricular voltage mapping avoiding "false scar" detection in patients with no evidence of structural heart disease

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Long-Term Follow-Up In Paroxysmal Atrial Fibrillation Patients With Documented Isolated Trigger

AimsSupraventricular tachycardias may trigger atrial fibrillation (AF). The aim of the study was to evaluate the prevalence of supraventricular tachycardia (SVT) inducibility in patients referred for AF ablation and to evaluate the effects of SVT ablation on AF recurrences.Methods and results249 patients (mean age: 54 ± 14 years) referred for paroxysmal AF ablation were studied. In all patients, only AF relapses had been documented in the clinical history. 47 patients (19%; mean age: 42 ± 11 years) had inducible SVT during the electrophysiological study and underwent an ablation targeted only at SVT suppression. Ablation was successful in all 47 patients. The ablative procedures were: 11 slow-pathway ablations for atrioventricular nodal re-entrant tachycardia; 6 concealed accessory pathway ablations for atrioventricular re-entrant tachycardia; 17 focal ectopic atrial tachycardia ablations; 13 with only one arrhythmogenic pulmonary vein. No recurrences of SVT were observed during the follow-up (32 ± 18 months). 4 patients (8.5%) showed recurrence of at least one episode of AF. Patients with inducible SVT had less structural heart disease and were younger than those without inducible SVT.ConclusionA significant proportion of candidates for AF ablation are inducible for an SVT. SVT ablation showed a preventive effect on AF recurrences. Those patients should be selected for simpler ablation procedures tailored only to the triggering arrhythmia suppression

Investigating the Paracrine Role of Perinatal Derivatives: Human Amniotic Fluid Stem Cell-Extracellular Vesicles Show Promising Transient Potential for Cardiomyocyte Renewal

Cardiomyocyte renewal represents an unmet clinical need for cardiac regeneration. Stem cell paracrine therapy has attracted increasing attention to resurge rescue mechanisms within the heart. We previously characterized the paracrine effects that human amniotic fluid-derived stem cells (hAFSC) can exert to provide cardioprotection and enhance cardiac repair in preclinical models of myocardial ischemia and cardiotoxicity. Here, we analyze whether hAFSC secretome formulations, namely, hAFSC conditioned medium (hAFSC-CM) over extracellular vesicles (hAFSC-EVs) separated from it, can induce cardiomyocyte renewal. c-KIT+ hAFSC were obtained by leftover samples of II trimester prenatal amniocentesis (fetal hAFSC) and from clinical waste III trimester amniotic fluid during scheduled C-section procedures (perinatal hAFSC). hAFSC were primed under 1% O2 to enrich hAFSC-CM and EVs with cardioactive factors. Neonatal mouse ventricular cardiomyocytes (mNVCM) were isolated from cardiac tissue of R26pFUCCI2 mice with cell cycle fluorescent tagging by mutually exclusive nuclear signal. mNVCM were stimulated by fetal versus perinatal hAFSC-CM and hAFSC-EVs to identify the most promising formulation for in vivo assessment in a R26pFUCCI2 neonatal mouse model of myocardial infarction (MI) via intraperitoneal delivery. While the perinatal hAFSC secretome did not provide any significant cardiogenic effect, fetal hAFSC-EVs significantly sustained mNVCM transition from S to M phase by 2-fold, while triggering cytokinesis by 4.5-fold over vehicle-treated cells. Treated mNVCM showed disorganized expression of cardiac alpha-actinin, suggesting cytoskeletal re-arrangements prior to cell renewal, with a 40% significant downregulation of Cofilin-2 and a positive trend of polymerized F-Actin. Fetal hAFSC-EVs increased cardiomyocyte cell cycle progression by 1.8-fold in the 4-day-old neonatal left ventricle myocardium short term after MI; however, such effect was lost at the later stage. Fetal hAFSC-EVs were enriched with a short isoform of Agrin, a mediator of neonatal heart regeneration acting by YAP-related signaling; yet in vitro application of YAP inhibitor verteporfin partially affected EV paracrine stimulation on mNVCM. EVs secreted by developmentally juvenile fetal hAFSC can support cardiomyocyte renewal to some extension, via intercellular conveyance of candidates possibly involving Agrin in combination with other factors. These perinatal derivative promising cardiogenic effects need further investigation to define their specific mechanism of action and enhance their potential translation into therapeutic opportunity