3 research outputs found
Association between preoperative levels of 25-hydroxyvitamin D and hospital-acquired infections after hepatobiliary surgery: A prospective study in a third-level hospital
Introduction
Evidence implicates vitamin D deficiency in poorer outcomes and increased susceptibility to hospital-acquired infections (HAIs). This study examined the association between serum vitamin D levels and HAIs in a population of hepatobiliary surgery patients.
Methods
Participants in this prospective analytical observational study were patients who underwent hepatobiliary surgery in a tertiary hospital in Aragon, Spain, between February 2018 and March 2019. Vitamin D concentrations were measured at admission and all nosocomial infections during hospitalization and after discharge were recorded.
Results
The mean 25-hydroxyvitamin D concentration of the study population (n = 301) was 38.56 nmol/L, which corresponds to vitamin D deficiency. Higher vitamin D concentrations were associated with a decreased likelihood of developing a HAI in general (p = 0.014), and in particularly surgical site infection (p = 0.026). The risk of HAI decreased by 34% with each 26.2-nmol/L increase in serum vitamin D levels.
Conclusions
Vitamin D levels may constitute a modifiable risk factor for postoperative nosocomial infections in hepatobiliary surgery patients
Infecci贸n del sitio quir煤rgico en cirug铆a hepatobiliopancre谩tica y su relaci贸n con la concentraci贸n s茅rica de vitamina D
Introducci贸n
La relaci贸n entre las infecciones nosocomiales en pacientes quir煤rgicos y la vitamina D ha sido estudiada por algunos autores. Sin embargo, hasta la fecha no existe ning煤n estudio realizado sobre pacientes de cirug铆a hepatobiliar. El objetivo de nuestro trabajo es estudiar la infecci贸n del sitio quir煤rgico (ISQ) en la unidad de cirug铆a hepatobiliar, y valorar su relaci贸n con la concentraci贸n s茅rica de vitamina D.
M茅todos
Se llev贸 a cabo un estudio anal铆tico observacional de pacientes sucesivos intervenidos en la unidad de cirug铆a hepatobiliar de nuestro centro durante un a帽o. Se incluyeron las intervenciones relativas a enfermedad biliar, pancre谩tica y hep谩tica. Se determinaron los niveles de vitamina D al ingreso, as铆 como las ISQ de tipo superficial, profunda y 贸rgano-cavitaria diagnosticadas durante el estudio. El seguimiento del paciente se realiz贸 durante al menos un mes tras la cirug铆a, dependiendo de la enfermedad. La estad铆stica se realiz贸 mediante el programa estad铆stico R v.3.1.3.
Resultados
La muestra qued贸 constituida por 321 pacientes, de los cuales el 25, 8% present贸 ISQ a expensas fundamentalmente de las infecciones 贸rgano-cavitarias que presentaron una incidencia del 24, 3%. Concentraciones s茅ricas superiores a 33, 5 nmol/l demostraron reducir en un 50% el riesgo de ISQ.
Conclusiones
Las concentraciones elevadas de vitamina D en sangre demostraron ser un factor protector frente a las ISQ (OR: 0, 99).
Nuestros resultados sugieren una relaci贸n directa entre la concentraci贸n s茅rica de vitamina D y la ISQ, justificando la realizaci贸n de nuevos estudios prospectivos.
Introduction: While several studies have examined the correlation between vitamin D concentrations and post-surgical nosocomial infections, this relationship has yet to be characterized in hepatobiliary surgery patients. We investigated the relationship between serum vitamin D concentration and the incidence of surgical site infection (SSI) in patients in our hepatobiliary surgery unit.
Methods: Participants in this observational study were 321 successive patients who underwent the following types of interventions in the hepatobiliary surgery unit of our center over a 1-year period: cholecystectomy, pancreaticoduodenectomy, total pancreatectomy, segmentectomy, hepatectomy, hepaticojejunostomy and exploratory laparotomy. Serum vitamin D levels were measured upon admission and patients were followed up for 1 month. Mean group values were compared using a Student's T-test or Chi-squared test. Statistical analyses were performed using the Student's T-test, the Chi-squared test, or logistic regression models.
Results: Serum concentrations >33.5 nmol/l reduced the risk of SSI by 50%. Out of the 321 patients analyzed, 25.8% developed SSI, mainly due to organ-cavity infections (incidence, 24.3%). Serum concentrations of over 33.5 nmol/l reduced the risk of SSI by 50%.
Conclusions: High serum levels of vitamin D are a protective factor against SSI (OR, 0.99). Our results suggest a direct relationship between serum vitamin D concentrations and SSI, underscoring the need for prospective studies to assess the potential benefits of vitamin D in SSI prevention