A Novel Method to Solve Assignment Problem in Fuzzy Environment

In the literature, there are various methods to solve assignment problems (APs) in which parameters are represented by triangular or trapezoidal fuzzy numbers. In this paper, we compare the assignment cost calculated by existing method with the assignment cost which has been found out in this paper without converting fuzzy assignment problem (AP) into crisp AP by using Fuzzy Hungarian Method (FHM), Robust’s Ranking Technique and operations for subtraction and division on triangular fuzzy number (TFN) proposed by Gani and Assarudeen (2012). Keywords: Fuzzy arithmetic, Triangular Fuzzy Number, Robust’s Ranking Function, Assignment Problem

FORMULATION AND EVALUATION OF MASLINIC ACID LOADED TRANSDERMAL PATCHES

Objective: To develop and evaluate Transdermal patch of Maslinic acid for Transdermal drug delivery. The current study is to develop Transdermal drug delivery system. Methods: Suitable method such as Solvent Casting Technique of Film Casting Technique are used for preparation of Transdermal patch. Results: The prepared Transdermal patches were transparent, smooth, uniform and flexible. The method adopted for the preparation of the system was found satisfactory. Conclusion: Various formulations were developed by using hydrophilic and hydrophobic polymers like HPMC E5 and EC respectively in single and combinations by solvent evaporation technique with the incorporation of penetration enhancer such as dimethylsulfoxide and dibutyl phthalate as plasticizer In vitro studies concluded that HPMC E5 patches has better release than that of EC patches, which may be attributed to high water vapour permeability of HPMC patches and hydrophobic nature of EC. An attempt was made to incorporate HPMC E5 and EC to the monolithic system for better release and prolong the duration of release. Formulation F7 containing an equal ratio of HPMC E5: EC (5:5) showed maximum and sustained release of 86.816±0.264 within 24 h. Kinetic models were used to confirm the release mechanism of the formulations. Maslinic acid release from the patches F1 to F7 followed non Fickian diffusion rate controlled mechanism

Dissolution Method Development and Validation for Estimation of Noscapine Tablets

A dissolution method was developed and UV spectrophotometry was developed for the evaluation of the dissolution of tablets containing 15 mg Noscapine .The dissolution medium 0.1 N HCl was found suitable to ensure sink conditions. USP Apparatus 2, 900 mL dissolution medium 45 minutes and 100 RPM were fixed. Dissolution profiles were generated at 10, 15, 20,   30; 45 min. Dissolution samples were analyzed with UV spectrophotometer at 213 nm. The UV method for determination of tablet was developed and validated. The method presented linearity (R2 = 0.999) in the concentration range of 1–9 μg/mL. The recoveries were good, ranging from 97.18% to 101.45%. The intraday and Interday precision results were 0.54% and 0.78% RSD, respectively. The developed dissolution test is adequate for its purpose and can be applied for the quality control of tablets. Keywords: Dissolution test; Noscapine; Tablets; UV Spectrophotometry metho

A COMPARATIVE STUDY OF PREVALENCE OF ANEMIA AND ITS RISK FACTORS AMONG SCHOOL-GOING ADOLESCENT GIRLS IN THE FIELD PRACTICE AREAS OF MEDICAL COLLEGE IN GAUTAM BUDDHA NAGAR DISTRICT

Objectives: (1) The study was to determine the prevalence of iron deficiency anemia among adolescent girls in the field practice areas of a medical college of GautamBuddha Nagar district and (2) to assess the risk factors associated with iron deficiency anemia among adolescent girls in the field practice areas of a medical college of GautamBuddha Nagar district. Methods: A school-based cross-sectional study was conducted to assess the prevalence of anemia among adolescent girls of the field practice areas of the medical college of Gautam Buddha Nagar District. The sample size came out to be 236. One school each from RHTC and UHTC was selected randomly, and all adolescent girls were enrolled in the study. Results: The present study was conducted on 684 adolescent females (251 from RHTC and 433 from UHTC) in our study period of 3 months. The prevalence of anemia in the whole population was 42%, 54.5% among rural and 35.5% of adolescents in urban area were found to be anemic at the time of the study. The factors that were found to be significantly associated with adolescent anemia were age of onset of menarche, history of albendazole intake, residing in joint family, and lower socioeconomic status. Conclusion: The prevalence was high among girls who were above 16 years of age and girls who belonged to lower socio-economic groups and belonging to rural area. There is a need for a regular supply of iron and folic acid tablets and for improving medication adherence regarding consuming these tablets among adolescent girls and also about the dietary advice

FORMULATION AND EVALUATION OF NUTRACEUTICAL TABLET USING HERBAL DRURS BY DIRECT COMPRESSION METHOD

Aim: The objective of present study was to formulate and evaluate the nutraceutical tablets with different combination of herbal drugs. Material and Method: The nutraceutical tablet containing lactose and mannitol as diluent and containing natural drugs like clove and cinnamon which was prepared by direct compression method. The compressed formulations were subject to several evaluation parameters like appearance, thickness, weight variation, hardness and friability. Results: The results of all evaluation parameters of nutraceutical tablet were within the acceptable limit. Pre-compression studies of nutraceutical tablet show satisfactory results. The thickness, hardness, weight variation, and friability of nutraceutical tablet were found to in acceptable range. The in-vitro drug release of eugenol from optimised nutraceutical formulation was found to be 90.23%. Significant results were obtained from present study. Discussion: The finding of current investigation clearly found that the health promotion of the body could be done by nutraceuticals. Keywords: Direct compression, Nutraceutical, Eugenol, In-vitro drug release

Green Synthesis and Bioactivity of Copper Nanoparticles from Asparagus aethiopicus and Asparagus densiflorus

An aqueous extract of the shade-dried parts of Asparagus aethiopicus L. and Asparagus densiflorus (Kunth) Jessop was used to synthesize copper (CuO) nanoparticles (Cu NPs). UV-visible spectroscopy was performed to assess the formation of Cu NPs. Maximum absorbance was obtained between 310–360 nm, confirming the formation of Cu NPs. CuO NPs were effective against Pseudomonas aeruginosa (ATCC 27853), a gram-negative human pathogenic bacterium. The bacterial growth curve showed that the NPs inhibited bacterial growth. This study was conducted using different parts of the plant, such as the roots, shoots, fruits, and seeds of A. aethiopicus and the roots and shoots of A. densiflorus. The fruit and seeds of A. aethiopicus showed better results than the roots and shoots. Therefore, employing green synthetic processes inhibits the release of harmful by-products. Compared to traditional techniques of NP synthesis, the transition to the extracellular production of CuO NPs utilizing dried biomass appears to be economical and environmentally beneficial

Laboratory Investigation of Indigenous Consortia TERIJ-188 for Incremental Oil Recovery

Bacterial Profile modification is an efficient process which brings the alteration in permeability of the porous media of the reservoir by selective plugging which eventually recover the residual oil. It is an advantageous and feasible method for residual oil recovery from high permeability zones of the reservoir. In this study, indigenous bacterial consortia, TERIJ-188 was developed from Gujarat oil fields. TERIJ-188 was identified as Thermoanaerobacter sp., Thermoanaerobacter brockii, Thermoanaerobacter italicus, Thermoanaerobacter mathranii, Thermoanaerobacter thermocopriae. The novelty of consortia was that it produces biomass (850 mg l-1), bio-surfactant (500 mg l-1), and volatile fatty acids (495 mg l-1) at 70°C in the span of 10 days, which are adequate to alter the permeability and sweep efficiency of high permeability zones facilitating the displacement of oil. The biosurfactant was analyzed for its functional group by FTIR and NMR techniques which indicate the presence of C-N bond, aldehydes, triacylglycerols. TERIJ-188 showed an effective reduction in permeability at residual oil saturation from 28.3 to 11.3 mD and 19.2% incremental oil recovery in a core flood assay. Pathogenicity test suggested that TERIJ-188 is non-toxic, non-virulent and safe for field implementation

Bio Nanotechnological Intervention: A Sustainable Alternative to Treat Dye Bearing Waste Waters

Waste water treatment issues have been a growing problems these days. It has become stringently important to treat waste water prior its release into adjoining surface water bodies. In recent past, bio nanotechnological solutions have proved to be of paramount importance in circumventing the issues associated with dye bearing waste waters. Nanoparticles have a great potential to be used in waste water treatment. Its unique characteristic of having high surface area can be used efficiently for removing toxic metal ions, disease causing microbes, organic and inorganic solutes from water. Various classes of nanomaterials have been efficiently utilized for above cited facts including treatment of dye bearing waste water released from textile industries like metal-containing nanoparticles, carbonaceous nanomaterials, zeolites and dendrimers. The paper presents a comprehensive review of recent advances on different nanomaterial based mitigation strategies. Special emphasis has been given to green synthesis of nanoparticles aimed to address problems associated with textile effluents through nano bioremediation

Sustainable green approach to synthesize Fe 3 O 4 /α-Fe 2 O 3 nanocomposite using waste pulp of Syzygium cumini and its application in functional stability of microbial cellulases

Synthesis of nanomaterials following green routes have drawn much attention in recent years due to the low cost, easy and eco-friendly approaches involved therein. Therefore, the current study is focused towards the synthesis of Fe(3)O(4)/α-Fe(2)O(3) nanocomposite using waste pulp of Jamun (Syzygium cumini) and iron nitrate as the precursor of iron in an eco-friendly way. The synthesized Fe(3)O(4)/α-Fe(2)O(3) nanocomposite has been extensively characterized through numerous techniques to explore the physicochemical properties, including X-ray diffraction, Fourier transform infrared spectroscopy, Raman spectroscopy, Ultraviolet-Vis spectroscopy, field emission scanning electron microscope, high resolution transmission electron microscope and vibrating sample magnetometer. Further, efficiency of the Fe(3)O(4)/α-Fe(2)O(3) nanocomposite has been evaluated to improve the incubation temperature, thermal/pH stability of the crude cellulase enzymes obtained from the lab isolate fungal strain Cladosporium cladosporioides NS2 via solid state fermentation. It is found that the presence of 0.5% Fe(3)O(4)/α-Fe(2)O(3) nanocomposite showed optimum incubation temperature and thermal stability in the long temperature range of 50–60 °C for 15 h along with improved pH stability in the range of pH 3.5–6.0. The presented study may have potential application in bioconversion of waste biomass at high temperature and broad pH range