A structure marker study for Pd_2Si formation: Pd moves in epitaxial Pd_2Si

A sample with the configuration Si (111)/single crystalline Pd_2Si/polycrystalline Pd_2Si/Pd is used to study the dominant moving species during subsequent Pd_2Si formation by annealing at 275 °C. The interface between monocrystalline and polycrystalline Pd_2Si is used as a marker to monitor the dominant moving species. The result shows that Pd is the dominant moving species in the monocrystal

Model reduction in power systems using Krylov subspace methods

This paper describes the use of Krylov subspace methods in the model reduction of power systems. Additionally, a connection between the Krylov subspace model reduction and coherency in power systems is proposed, aiming at retaining some physical relationship between the reduced and the original system

Prevalence of migraine in patients of allergic rhinitis

Background: Migraine and allergic rhinitis are common disorders. Studies have shown increased frequency of migraine headaches in patients with allergic rhinitis. The aim of this study is to identify how age, sex and degree of allergic sensitization influences the occurrence, severity and treatment outcome of migraine headaches in patients with allergic rhinitis.Methods: The study was conducted between 2014 and 2018 in a tertiary care hospital. 150 patients diagnosed with allergic rhinitis clinically were selected and total serum IgE levels were estimated. These patients were subjected to a detailed history taking to determine the characteristics of headache. All classifiable headache diagnoses had met criteria of the International Classification of Headache Disorders-II-2004. Severity of headache was assessed based on MIDAS score. The data was accessed based on age, sex, serum IgE levels, frequency and severity of migraine attacks and the treatment outcome using statistical methods.Results: The prevalence of migraine in this study was 68% among those who had allergic rhinitis. In this study out 150 patients 111 were females and 39 were males. Comparatively females’ patients 84 (75.7%) were found to be more prone for migraine. Majority patients were in the age group of 20 to 40 years (cumulative percentage of 67.3%). There was a negative correlation between age and IgE levels with r= -0.092. In comparison patients with higher levels of IgE (mean 3633) had more severe headaches. Patients with higher levels of IgE required a longer duration of treatment.Conclusions: This study shows that allergic rhinitis is a risk factor for development of migraine. Apart from high prevalence of migraine in patients with allergic rhinitis it is evident from the study that female sex, younger age group and high degree of allergic sensitization also play an important role as the severity of migraine and treatment course depend on these parameters. Hence the treatment for migraine in patients should aim at reducing the allergic sensitization in addition to concurrent treatment for migraine

Superfluid, Mott-Insulator, and Mass-Density-Wave Phases in the One-Dimensional Extended Bose-Hubbard Model

We use the finite-size density-matrix-renormalization-group (FSDMRG) method to obtain the phase diagram of the one-dimensional ($d = 1$) extended Bose-Hubbard model for density $\rho = 1$ in the $U-V$ plane, where $U$ and $V$ are, respectively, onsite and nearest-neighbor interactions. The phase diagram comprises three phases: Superfluid (SF), Mott Insulator (MI) and Mass Density Wave (MDW). For small values of $U$ and $V$, we get a reentrant SF-MI-SF phase transition. For intermediate values of interactions the SF phase is sandwiched between MI and MDW phases with continuous SF-MI and SF-MDW transitions. We show, by a detailed finite-size scaling analysis, that the MI-SF transition is of Kosterlitz-Thouless (KT) type whereas the MDW-SF transition has both KT and two-dimensional-Ising characters. For large values of $U$ and $V$ we get a direct, first-order, MI-MDW transition. The MI-SF, MDW-SF and MI-MDW phase boundaries join at a bicritical point at ($U, V) = (8.5 \pm 0.05, 4.75 \pm 0.05)$.Comment: 10 pages, 15 figure

T-Cell Assays for Tuberculosis Infection: Deriving Cut-Offs for Conversions Using Reproducibility Data

Although interferon-gamma release assays (IGRA) are promising alternatives to the tuberculin skin test, interpretation of repeated testing results is hampered by lack of evidence on optimal cut-offs for conversions and reversions. A logical start is to determine the within-person variability of T-cell responses during serial testing.We performed a pilot study in India, to evaluate the short-term reproducibility of QuantiFERON-TB Gold In Tube assay (QFT) among 14 healthcare workers (HCWs) who underwent 4 serial QFT tests on day 0, 3, 9 and 12. QFT ELISA was repeated twice on the same sets of specimens. We assessed two types of reproducibility: 1) test-retest reproducibility (between-test variability), and 2) within-person reproducibility over time. Test-retest reproducibility: with dichotomous test results, extremely high concordance was noticed between two tests performed on the same sets of specimens: of the 56 samples, the test and re-test results agreed for all but 2 individuals (kappa = 0.94). Discordance was noted in subjects who had IFN-gamma values around the cut-off point, with both increases and decreases noted. With continuous IFN-gamma results, re-test results tended to produce higher estimates of IFN-gamma than the original test. Within-person reproducibility: when continuous IFN-gamma data were analyzed, the within-person reproducibility was moderate to high. While persons with negative QFT results generally stayed negative, positive results tended to vary over time. Our data showed that increases of more than 16% in the IFN-gamma levels are statistically improbable in the short-term.Conservatively assuming that long-term variability might be at least twice higher than short-term, we hypothesize that a QFT conversion requires two conditions to be met: 1) change from negative to positive result, and 2) at least 30% increase in the baseline IFN-gamma response. Larger studies are needed to confirm our preliminary findings, and determine the conversion thresholds for IGRAs

Autologous Bone Marrow Stem Cells in the Treatment of Chronic Liver Disease

Chronic liver disease (CLD) is increasing worldwide yet there has been no major advance in effective therapies for almost five decades. There is mounting evidence that adult haematopoietic stem cells (HSC) are capable of differentiating into many types of tissue, including skeletal and cardiac muscle, neuronal cells, pneumocytes and hepatocytes. These recent advances in regenerative medicine have brought hope for patients with liver cirrhosis awaiting transplantation. New findings in adult stem cell biology are transforming our understanding of tissue repair raising hopes of successful regenerative hepatology. Although all clinical trials to date have shown some improvement in liver function and CD34(+) cells have been used safely for BM transplantation for over 20 years, only randomised controlled clinical trials will be able to fully assess the potential clinical benefit of adult stem cell therapy for patients with CLD. This article focuses on the potential of bone marrow stem cells (BMSCs) in the management of CLD and the unresolved issues regarding their role. We also outline the different mechanisms by which stem cells may impact on liver disease

Transient Stability Simulation by Waveform Relaxation Methods

In this paper, a new methodology for power system dynamic response calculations is presented. The technique known as the waveform relaxation has been extensively used in transient analysis of VLSI circuits and it can take advantage of new architectures in computer systems such as parallel processors. The application in this paper is limited to swing equations of a large power system. Computational results are presented

Zero Temperature Insulator-Metal Transition in Doped Manganites

We study the transition at T=0 from a ferromagnetic insulating to a ferromagnetic metallic phase in manganites as a function of hole doping using an effective low-energy model Hamiltonian proposed by us recently. The model incorporates the quantum nature of the dynamic Jahn-Teller(JT) phonons strongly coupled to orbitally degenerate electrons as well as strong Coulomb correlation effects and leads naturally to the coexistence of localized (JT polaronic) and band-like electronic states. We study the insulator-metal transition as a function of doping as well as of the correlation strength U and JT gain in energy E_{JT}, and find, for realistic values of parameters, a ground state phase diagram in agreement with experiments. We also discuss how several other features of manganites as well as differences in behaviour among manganites can be understood in terms of our model.Comment: To be published in Europhysics Letter

Quality and Reporting of Diagnostic Accuracy Studies in TB, HIV and Malaria: Evaluation Using QUADAS and STARD Standards

BackgroundPoor methodological quality and reporting are known concerns with diagnostic accuracy studies. In 2003, the QUADAS tool and the STARD standards were published for evaluating the quality and improving the reporting of diagnostic studies, respectively. However, it is unclear whether these tools have been applied to diagnostic studies of infectious diseases. We performed a systematic review on the methodological and reporting quality of diagnostic studies in TB, malaria and HIV.MethodsWe identified diagnostic accuracy studies of commercial tests for TB, malaria and HIV through a systematic search of the literature using PubMed and EMBASE (2004–2006). Original studies that reported sensitivity and specificity data were included. Two reviewers independently extracted data on study characteristics and diagnostic accuracy, and used QUADAS and STARD to evaluate the quality of methods and reporting, respectively.FindingsNinety (38%) of 238 articles met inclusion criteria. All studies had design deficiencies. Study quality indicators that were met in less than 25% of the studies included adequate description of[...] and description of the team executing the test and management of indeterminate/outlier results (both 17%). The use of STARD was not explicitly mentioned in any study. Only 22% of 46 journals that published the studies included in this review required authors to use STARD