Compression Vehicle: A Technical Review

The compressed dosage forms such as tablets are the most preferred and widely accepted due to their dosing accuracy, compactness, manufacturing efficiency, stability and better patient compliance. Pharmaceutical Diluents or filler binders, usually referred to as Compression vehicles, contribute significantly to the formulation blend, especially in compressed solid dosage forms containing potent active pharmaceutical ingredients. The functionality of these filler binders mainly depends on their physicochemical and mechanical properties. They provide performance characteristics and quality attributes of the compressed solid dosage forms. Understanding the effect of compression vehicles' bulk and particle level properties is of prime importance in optimising various process parameters and unit operations. The mechanical properties of a compression blend viz plasticity, elasticity, viscoelasticity, brittleness, and bonding index play an essential role in the effective compaction of compressed solid dosage forms. In addition to this, the porosity, volume, density or void-volume ratio of compact with applied pressure is required to understand the compaction behaviour of solid to form a compact with well-defined geometry

In vitro study on anthelmintic activity of Aristolochia indica and A. tagala roots

The present study has been undertaken to screen the anthelmintic potential of aqueous root extracts of Aristolochia indica Linn. and A. tagala Cham. against adult Indian earthworm Pheritima posthuma and round worms Ascaridia galli. Different concentrations of the extracts ranging from 2-8 mg/mL were screened. Piperazine citrate was used as reference standard. Extract of A. tagala was found to be more potent and effective at the dose level of 2 mg/mL compared to the extract of A. indica. Extracts showed dose dependant activity. The study reports that the plants A. indica and A. tagala roots possess potent anthelmintic properties.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Synthesis, Antibacterial and Analgesic Activities of 4-[1-Oxo-3-(substituted aryl)-2-propenyl]-3-(4-methylphenyl) sydnones

A series of sydnone derivatives containing styryl ketone moiety, 4-[1-oxo-3-(substituted aryl)-2-propenyl]-3-(4-methylphenyl)sydnones (6a-i) has been synthesized and characterized by spectral data. The synthesized compounds have been screened for preliminary antibacterial activity by cup plate method and analgesic activity by the method of acetic acid induced writhing in mice. The chloro and nitro derivatives showed good antibacterial activity against both gram positive and gram negative bacteria while the chloro and furyl derivatives exhibited highest analgesic effect among the series