Synthesis and antimicrobial activity of pyrimidinylsulfamoyl azolylbenzamides

907-915A variety of sulfonamide linked azolyl pyrimidines have been prepared and studied for their antimicrobial activity. The chloro and nitro substituted thiazolyl pyrimidines (12c and 12e) display potential antibacterial activity against Bacillus subtilis. The chloro, bromo and nitro substituted imidazolyl pyrimidines (13c, 13d and 13e) show potential antifungal activity against Aspergillus niger

Two new flavonoids from <i style="mso-bidi-font-style:normal">Ageratum conyzoides</i>

1479-1482Two new flavonoids, (2S)-7,3',4'-trimethoxyflavanone 1 and (2<i style="mso-bidi-font-style: normal">S)-7-methoxy-3',4'-methylenedioxyflavan <b style="mso-bidi-font-weight: normal">2 together with three known flavonoids, 5,6,7,8,5'-pentamethoxy-3',4'-methylenedioxy­flavone, 5,2'-dihydroxy-7-methoxyflavone 2'-O-β-D-glucopyrano­side and kaempferol-3-O-α-L-rhamnopyranoside have been isolated from the whole plant of Ageratum conyzoides. The structures of the new as well as known compounds have been elucidated by extensive 2D NMR, ESI-TOFMS and chemical studies

Heterocyclization reactions of ketene dithiolates

665-670The reaction of ketene dithiolates in the presence of K2CO3 lead to bisthioalkylated products and thienothiophene derivatives depending on the strength of the base. The 1,5-diamino groups in thienothiophene compounds are subjected to heterocyclization under PTC conditions to get a variety of fused heterocycles

Synthesis and cytotoxic activity of sulfur linked mono / bis heterocycles

1173-1178A variety of sulfur linked mono / bis heterocycles have been prepared and their cytotoxic activity on A549 lung adenocarcinoma cells studied. The imidazolyl and benzimidazolyl thiadiazoles (7c, 8c) display appreciable cytotoxic activity against A549 cells