What is the dietary treatment for low HDL cholesterol?

Low-carbohydrate diets raise high-density lipoprotein (HDL) cholesterol levels by approximately 10%; soy protein with isoflavones raises HDL by 3% (strength of recommendation [SOR]: C, based on meta-analysis of physiologic parameters). The Dietary Approaches to Stop Hypertension (DASH) diet and multivitamin supplementation raise HDL 21% to 33% (SOR: C, based on single randomized trial each measuring physiologic parameters). No other dietary interventions studied raise HDL (SOR: C, based on meta-analysis of physiologic parameters)

Black Bone

The Appalachian region stretches from Mississippi to New York, encompassing rural areas as well as cities from Birmingham to Pittsburgh. Though Appalachia\u27s people are as diverse as its terrain, few other regions in America are as burdened with stereotypes. Author Frank X Walker coined the term Affrilachia to give identity and voice to people of African descent from this region and to highlight Appalachia\u27s multicultural identity. This act inspired a group of gifted artists, the Affrilachian Poets, to begin working together and using their writing to defy persistent stereotypes of Appalachia as a racially and culturally homogenized region. After years of growth, honors, and accomplishments, the group is acknowledging its silver anniversary with Black Bone. Edited by two newer members of the Affrilachian Poets, Bianca Lynne Spriggs and Jeremy Paden, Black Bone is a beautiful collection of both new and classic work and features submissions from Frank X Walker, Nikky Finney, Gerald Coleman, Crystal Wilkinson, Kelly Norman Ellis, and many others. This illuminating and powerful collection is a testament to a groundbreaking group and its enduring legacy. Bianca Lynne Spriggs is a writer, multidisciplinary artist, and assistant professor of English at Ohio University. She is the recipient of a Kentucky Arts Council 2013 Al Smith Individual Arts Fellowship in Poetry, as well as a recipient of multiple artist enrichment grants from the Kentucky Foundation for Women. Spriggs is the author or coeditor of a number of books, including Kaffir Lily, Call Her by Her Name, and The Galaxy Is a Dance Floor. Jeremy Paden is an associate professor of Spanish and Latin American literature at Transylvania University. His poems have appeared in such places as the Atlanta Review, Beloit Poetry Journal, Cortland Review, Louisville Review, Naugatuck River Review, pluck! and Rattle, among others. He is the author of two collections of poems, Broken Tulips and ruina montium.https://uknowledge.uky.edu/upk_cr/1004/thumbnail.jp

Which history and physical findings are most useful in identifying rotator cuff tears?

It's unknown which -- if any -- historical factors are most useful, because no studies evaluating their accuracy with rotator cuff tears have been done. As for physical findings, no single physical examination finding is sensitive or specific enough to detect partial-thickness rotator cuff tears (strength of recommendation [SOR]: B, systematic review of lower-quality cohort studies)

Ice-sheet bed 3-D tomography

This is the published version. Copyright 2010 International Glaciological SocietyInformation on bed topography and basal conditions is essential to developing the next-generation ice-sheet models needed to generate a more accurate estimate of ice-sheet contribution to sea-level rise. Synthetic aperture radar (SAR) images of the ice–bed can be analyzed to obtain information on bed topography and basal conditions. We developed a wideband SAR, which was used during July 2005 to perform measurements over a series of tracks between the GISP2 and GRIP cores near Summit Camp, Greenland. The wideband SAR included an eight-element receive-antenna array with multiple-phase centers. We applied the MUltiple SIgnal Classification (MUSIC) algorithm, which estimates direction of arrival signals, to single-pass multichannel data collected as part of this experiment to obtain fine-resolution bed topography. This information is used for producing fine-resolution estimates of bed topography over a large swath of 1600m, with a 25m posting and a relative accuracy of approximately 10m. The algorithm-derived estimate of ice thickness is within 10m of the GRIP ice-core length. Data collected on two parallel tracks separated by 500m and a perpendicular track are compared and found to have difference standard deviations of 9.1 and 10.3m for the parallel and perpendicular tracks, respectively

Deliberation Model for On-Device Spoken Language Understanding

We propose a novel deliberation-based approach to end-to-end (E2E) spoken language understanding (SLU), where a streaming automatic speech recognition (ASR) model produces the first-pass hypothesis and a second-pass natural language understanding (NLU) component generates the semantic parse by conditioning on both ASR's text and audio embeddings. By formulating E2E SLU as a generalized decoder, our system is able to support complex compositional semantic structures. Furthermore, the sharing of parameters between ASR and NLU makes the system especially suitable for resource-constrained (on-device) environments; our proposed approach consistently outperforms strong pipeline NLU baselines by 0.82% to 1.34% across various operating points on the spoken version of the TOPv2 dataset. We demonstrate that the fusion of text and audio features, coupled with the system's ability to rewrite the first-pass hypothesis, makes our approach more robust to ASR errors. Finally, we show that our approach can significantly reduce the degradation when moving from natural speech to synthetic speech training, but more work is required to make text-to-speech (TTS) a viable solution for scaling up E2E SLU.Comment: Submitted to INTERSPEECH 202

NON-INVASIVE BLOOD PRESSURE AND OTHER PHYSIOLOGICAL DATA IN CHEMICALLY IMMOBILIZED BROWN BEARS (URSUS ARCTOS)

Free-ranging brown bears (Ursus arctos) were snared and subsequently darted with a combination of xylazine-ketamine in Croatia (n = 5) or darted from a helicopter with a combination of medetomidine-tiletamine-zolazepam in Scandinavia (n = 20). Three adults and one yearling (1 year old) bear were captured in Croatia, with one adult being captured twice. The Scandinavian bears were divided into Group A (yearlings, n = 7) and Group B (subadults, n = 2 and adults, n = 11). The exertion time (time from activation of the trap or from the start of the helicopter chase to recumbency) and the induction time (time from darting to recumbency) were recorded. The rectal temperature (Tr) was measured as soon as possible after induction and then monitored at frequent intervals (varied between individuals) in immobilized bears. Blood pressure (BP) was measured with a non-invasive method (Korotkoff's technique) every 5 minutes. The heart rate (HR), respiratory rate (RR), and arterial haemoglobin oxygen saturation (SpO2) were recorded every 5 minutes. Reliability of the BP monitoring technique, trends of variation of the physiological variables, and the factors related to the capture were assessed. Both exertion and induction times were longer in Croatian bears than in Scandinavian bears. In Croatian bears, the Tr was either constant or slightly decreasing, with hyperthermia recorded in two individuals (Tr > 39.0° C). In Scandinavian bears, 17 of 20 individuals developed an initial hyperthermia. Four of five bears in Croatia and 17 of 20 bears in Scandinavia showed a decreasing trend in systolic and mean BP over time. According to the Korotkoff method, all bears were hypertensive (mean BP > 130 mmHg) with varying severity, and the systolic pressure was significantly lower in yearlings when compared to subadults and adults. Yearlings had significantly (p < 0.05) higher HR than subadults and adults, however there was no significant differences in RR, SpO2, and Tr between the age groups. All Croatian bears and 13 of 20 Scandinavian bears were moderately to severely hypoxemic (SpO2 < 90%). Further studies with simultaneous invasive and non-invasive (Korotkoff) BP monitoring techniques are required to confirm the accuracy of methods used in this study. The data presented here provides evidence of the physiological impact of different capture methods and chemical immobilization of brown bears in Croatia and Scandinavia

Identification of Alternative Transcripts Encoding the Essential Murine Gammaherpesvirus Lytic Transactivator RTA

The essential immediate early transcriptional activator RTA, encoded by gene 50, is conserved among all characterized gammaherpesviruses. Analyses of a recombinant murine gammaherpesvirus 68 (MHV68) lacking both of the known gene 50 promoters (G50DblKo) revealed that this mutant retained the ability to replicate in the simian kidney epithelial cell line Vero but not in permissive murine fibroblasts following low-multiplicity infection. However, G50DblKo replication in permissive fibroblasts was partially rescued by high-multiplicity infection. In addition, replication of the G50DblKo virus was rescued by growth on mouse embryonic fibroblasts (MEFs) isolated from IFN-α/βR(−/−) mice, while growth on Vero cells was suppressed by the addition of alpha interferon (IFN-α). 5′ rapid amplification of cDNA ends (RACE) analyses of RNAs prepared from G50DblKo and wild-type MHV68-infected murine macrophages identified three novel gene 50 transcripts initiating from 2 transcription initiation sites located upstream of the currently defined proximal and distal gene 50 promoters. In transient promoter assays, neither of the newly identified gene 50 promoters exhibited sensitivity to IFN-α treatment. Furthermore, in a single-step growth analysis RTA levels were higher at early times postinfection with the G50DblKo mutant than with wild-type virus but ultimately fell below the levels of RTA expressed by wild-type virus at later times in infection. Infection of mice with the MHV68 G50DblKo virus demonstrated that this mutant virus was able to establish latency in the spleen and peritoneal exudate cells (PECs) of C57BL/6 mice with about 1/10 the efficiency of wild-type virus or marker rescue virus. However, despite the ability to establish latency, the G50DblKo virus mutant was severely impaired in its ability to reactivate from either latently infected splenocytes or PECs. Consistent with the ability to rescue replication of the G50DblKo mutant by growth on type I interferon receptor null MEFs, infection of IFN-α/βR(−/−) mice with the G50DblKo mutant virus demonstrated partial rescue of (i) acute virus replication in the lungs, (ii) establishment of latency, and (iii) reactivation from latency. The identification of additional gene 50/RTA transcripts highlights the complex mechanisms involved in controlling expression of RTA, likely reflecting time-dependent and/or cell-specific roles of different gene 50 promoters in controlling virus replication. Furthermore, the newly identified gene 50 transcripts may also act as negative regulators that modulate RTA expression. IMPORTANCE The viral transcription factor RTA, encoded by open reading frame 50 (Orf50), is well conserved among all known gammaherpesviruses and is essential for both virus replication and reactivation from latently infected cells. Previous studies have shown that regulation of gene 50 transcription is complex. The studies reported here describe the presence of additional alternatively initiated, spliced transcripts that encode RTA. Understanding how expression of this essential viral gene product is regulated may identify new strategies for interfering with infection in the setting of gammaherpesvirus-induced diseases

Self-affine subglacial roughness:consequences for radar scattering and basal water discrimination in northern Greenland

Subglacial roughness can be determined at a variety of length scales from radio-echo sounding (RES) data either via statistical analysis of topography or inferred from basal radar scattering. Past studies have demonstrated that subglacial terrain exhibits self-affine (power law) roughness scaling behaviour, but existing radar scattering models do not take this into account. Here, using RES data from northern Greenland, we introduce a self-affine statistical framework that enables a consistent integration of topographicscale roughness with the electromagnetic theory of radar scattering. We demonstrate that the degree of radar scattering, quantified using the waveform abruptness (pulse peakiness), is topographically controlled by the Hurst (roughness power law) exponent. Notably, specular bed reflections are associated with a lower Hurst exponent, with diffuse scattering associated with a higher Hurst exponent. Abrupt waveforms (specular reflections) have previously been used as a RES diagnostic for basal water, and to test this assumption we compare our radar scattering map with a recent prediction for the basal thermal state. We demonstrate that the majority of thawed regions (above pressure melting point) exhibit a diffuse scattering signature, which is in contradiction to the prior approach. Self-affine statistics provide a generalised model for subglacial terrain and can improve our understanding of the relationship between basal properties and ice-sheet dynamics.</p

Potential of Endangered Local Donkey Breeds in Meat and Milk Production

The problem of the erosion of animal genetic resources is evident in certain local donkey breeds, and their long-term sustainability can be achieved by economically repositioning them. To develop alternative and sustainable commercial programs, the meat and milk production characteristics of Istrian donkey and Littoral Dinaric donkey breeds were investigated. The meat production characteristics were examined in mature males, whose carcasses were dissected, and meat composition was determined using NIT spectrophotometry and gas chromatography. Milk yield and milk composition were determined in jennies in second or subsequent lactations by measuring milk volume and using infrared spectrometry and gas chromatography. Compared to the Littoral Dinaric donkey, the Istrian donkey has a higher carcass weight and dressing percentage (p < 0.001). The share of boneless meat in relation to live weight was 28.27% in the Istrian donkey and 26.18% in the Littoral Dinaric donkey. The absolute masses of primal cuts of meat in E, I, and II classes were significantly greater in Istrian donkeys than in Littoral Dinaric donkeys (p < 0.01), although the differences in the proportions of primal cuts were not significant. The breed did not have a significant impact on the color, pH, or meat composition. A significant influence of breed on milk yield, lactose, protein, and the fat content of milk was observed (p < 0.01). A significant influence of breed on the ratio of n-6/n-3 PUFA fatty acids in donkey milk was observed (p = 0.002). The values of the atherogenic and thrombogenic indexes were favorable, considering potential beneficial effects of donkey milk and meat on consumer health. The findings of this research suggest that local donkey breeds hold significant potential for meat and milk production, focusing on the uniqueness and quality of their products rather than the quantity of meat and milk they can produce

SHP-2 acts via ROCK to regulate the cardiac actin cytoskeleton

Noonan syndrome is one of the most common causes of human congenital heart disease and is frequently associated with missense mutations in the protein phosphatase SHP-2. Interestingly, patients with acute myelogenous leukemia (AML), acute lymphoblastic leukemia (ALL), juvenile myelomonocytic leukemia (JMML) and LEOPARD syndrome frequently carry a second, somatically introduced subset of missense mutations in SHP-2. To determine the cellular and molecular mechanisms by which SHP-2 regulates heart development and, thus, understand how Noonan-associated mutations affect cardiogenesis, we introduced SHP-2 encoding the most prevalent Noonan syndrome and JMML mutations into Xenopus embryos. Resulting embryos show a direct relationship between a Noonan SHP-2 mutation and its ability to cause cardiac defects in Xenopus; embryos expressing Noonan SHP-2 mutations exhibit morphologically abnormal hearts, whereas those expressing an SHP-2 JMML-associated mutation do not. Our studies indicate that the cardiac defects associated with the introduction of the Noonan-associated SHP-2 mutations are coupled with a delay or arrest of the cardiac cell cycle in M-phase and a failure of cardiomyocyte progenitors to incorporate into the developing heart. We show that these defects are a result of an underlying malformation in the formation and polarity of cardiac actin fibers and F-actin deposition. We show that these defects can be rescued in culture and in embryos through the inhibition of the Rho-associated, coiled-coil-containing protein kinase 1 (ROCK), thus demonstrating a direct relationship between SHP-2N308D and ROCK activation in the developing heart