Assessment of Anti-aging Efficacy of the Master Antioxidant Glutathione

A chief tripeptide antioxidant Glutathione (GSH) is present inside each body cell which may have a profound effect in the control of aging. The anti-aging potency of GSH and its role towards the progression of certain age-related disease is still unclear. Glutathione based articles were searched on PubMEd database since the very first study of glutathione related to its discovery in 1923 to its present status till 2016. The data was made more informative and precise by searching glutathione relevant reports on google. Those articles were selected which were indicating the association of glutathione with the progression of age-related diseases, pre-clinical and clinical studies and age-longevity effect. It was analyzed that the increased oxidative stress (elevated GSSG/GSH ratio) is responsible for the incidence of age-related diseases and different organs failure. The glutathione redox ratio (GSSG/GSH) was found to be more pro-oxidizing with aging which plays a chief role for the generation of reactive oxygen species (ROS) and subsequently damages the macromolecular structures affecting the normal body mechanisms and functions. The clinical data has recommended that glutathione is a potent therapeutic agent for the control of age-related diseases and experimental analysis has confirmed its prominent effect in age-longevity