Business Location & Economic Benefits

When deciding on a location for their firms, firm owners often consider that locating close to downtown will prove most profitable for their business, but is that always true? Our research will examine which economic factors contribute to the success of a business. We will analyze how the choice of location affects the economic return on investment for businesses in the Boise/Nampa metro area. This research will cover two important issues. First, we will discuss the importance of population data with respect to making future demographic and business projections. Second, we will discuss how amenities such as schools, availability of other public goods and services impact firm location choice. Understanding the impact of these variables will help prospective entrepreneurs when deciding on a new business location

Fibroblast growth factor signaling in mammalian tooth development

In this review, we discuss the central role of fibroblast growth factor (FGF) signalling in mammalian tooth development. The FGF family consists of 22 members, most of which bind to four different receptor tyrosine kinases, which in turn signal through a cascade of intracellular proteins. This signaling regulates a number of cellular processes, including proliferation, differentiation, cell adhesion and cell mobility. FGF signaling first becomes important in the presumptive dental epithelium at the initiation stage of tooth development, and subsequently, it controls the invagination of the dental epithelium into the underlying mesenchyme. Later, FGFs are critical in tooth shape formation and differentiation of ameloblasts and odontoblasts, as well as in the development and homeostasis of the stem cell niche that fuels the continuously growing mouse incisor. In addition, FGF signaling is critical in human teeth, as mutations in genes encoding FGF ligands or receptors result in several congenital syndromes characterized by alterations in tooth number, morphology or enamel structure. The parallel roles of FGF signaling in mouse and human tooth development demonstrate the conserved importance of FGF signaling in mammalian odontogenesis