Prognostic significance of anti-p53 and anti-KRas circulating antibodies in esophageal cancer patients treated with chemoradiotherapy

<p>Abstract</p> <p>Background</p> <p>P53 mutations are an adverse prognostic factor in esophageal cancer. P53 and KRas mutations are involved in chemo-radioresistance. Circulating anti-p53 or anti-KRas antibodies are associated with gene mutations. We studied whether anti-p53 or anti-KRas auto-antibodies were prognostic factors for response to chemoradiotherapy (CRT) or survival in esophageal carcinoma.</p> <p>Methods</p> <p>Serum p53 and KRas antibodies (abs) were measured using an ELISA method in 97 consecutive patients treated at Saint Louis University Hospital between 1999 and 2002 with CRT for esophageal carcinoma (squamous cell carcinoma (SCCE) 57 patients, adenocarcinoma (ACE) 27 patients). Patient and tumor characteristics, response to treatment and the follow-up status of 84 patients were retrospectively collected. The association between antibodies and patient characteristics was studied. Univariate and multivariate survival analyses were conducted.</p> <p>Results</p> <p>Twenty-four patients (28%) had anti-p53 abs. Abs were found predominantly in SCCE (p = 0.003). Anti-p53 abs were associated with a shorter overall survival in the univariate analysis (HR 1.8 [1.03-2.9], p = 0.04). In the multivariate analysis, independent prognostic factors for overall and progression-free survival were an objective response to CRT, the CRT strategy (alone or combined with surgery [preoperative]) and anti-p53 abs. None of the long-term survivors had p53 abs. KRas abs were found in 19 patients (23%, no difference according to the histological type). There was no significant association between anti-KRas abs and survival neither in the univariate nor in the multivariate analysis. Neither anti-p53 nor anti-KRas abs were associated with response to CRT.</p> <p>Conclusions</p> <p>Anti-p53 abs are an independent prognostic factor for esophageal cancer patients treated with CRT. Individualized therapeutic approaches should be evaluated in this population.</p

Structures chimiques spatiales ondes chimiques

Les phénomènes d’auto-organisation spatiale d’un milieu siège d’une réaction chimique ont fait l’objet de nombreux travaux depuis leur découverte qui remonte à une quinzaine d’années. Cependant leur mécanisme d’apparition reste encore, dans une large mesure, mal compris, voire incompris. Ainsi en est-il des structures, dites mosaïques, observées en couche mince et dont l’origine demeure une enigme. Il en va de même des ondes chimiques, dont on ignore si la naissance peut ou non découler d’une fluctuation. Une revue de la littérature montre qu’il existe davantage de questions posées que de réponses satisfaisantes. C’est pourquoi expérience et théorie doivent maintenant s’engager dans des voies nouvelles, afin de mieux comprendre ces phénomènes dont les milieux vivants offrent également certains exemples

Concentration of solutes by nanofiltration in organic solvents

International audienceNanofiltration is a membrane process well controlled in aqueous separations. Its use to perform organic separations is currently studied by many researchers to understand the occurring transport phenomena. Some authors have underlined the great influence of trio membrane– solvent–solute on separation efficiency [1–3] but very few have performed systematic studies with controlled parameters. In this work, a systematic study has been undertaken using a commonly used PDMS (polydimethylsiloxane) dense membrane, a series of organic solvent mixtures, and a series of solutes of various molar masses but of similar structures since belonging to the same polymer family

PRESENTATION DU FILM "LOIN DE L'EQUILIBRE"

Pas de Résumé disponibl

Réactions chimiques et diffusion : sources de structuration spatio-temporelle

On traite des structures spatiales induites par le couplage entre réaction chimique et diffusion des especes en solution aqueuse, en réacteur ouvert ou non. Après un rappel théorique, on décrit les désormais classiques structures cibles et spirales, puis differentes structures spatiales entretenues unidimensionnelles (stationnaires ou oscillantes) ou bidimensionnelles (ondes d’excitation cycliques) de découverte récente