The development of an advanced air mobility flight testing and simulation infrastructure

The emerging field of Advanced Air Mobility (AAM) holds great promise for revolutionizing transportation by enabling the efficient, safe, and sustainable movement of people and goods in urban and regional environments. AAM encompasses a wide range of electric vertical take-off and landing (eVTOL) aircraft and infrastructure that support their operations. In this work, we first present a new airspace structure by considering different layers for standard-performing vehicles (SPVs) and high-performing vehicles (HPVs), new AAM services for accommodating such a structure, and a holistic contingency management concept for a safe and efficient traffic environment. We then identify the requirements and development process of a testing and simulation infrastructure for AAM demonstrations, which specifically aim to explore the decentralized architecture of the proposed concept and its use cases. To demonstrate the full capability of AAM, we develop an infrastructure that includes advanced U-space services, real and simulated platforms that are suitable for future AAM use cases such as air cargo delivery and air taxi operations, and a co-simulation environment that allows all of the AAM elements to interact with each other in harmony. The considered infrastructure is envisioned to be used in AAM integration-related efforts, especially those focusing on U-space service deployment over a complex traffic environment and those analyzing the interaction between the operator, the U-space service provider (USSP), and the air traffic controller (ATC).European Union funding: 10101770

Management of acute diverticulitis with pericolic free gas (ADIFAS). an international multicenter observational study

Background: There are no specific recommendations regarding the optimal management of this group of patients. The World Society of Emergency Surgery suggested a nonoperative strategy with antibiotic therapy, but this was a weak recommendation. This study aims to identify the optimal management of patients with acute diverticulitis (AD) presenting with pericolic free air with or without pericolic fluid. Methods: A multicenter, prospective, international study of patients diagnosed with AD and pericolic-free air with or without pericolic free fluid at a computed tomography (CT) scan between May 2020 and June 2021 was included. Patients were excluded if they had intra-abdominal distant free air, an abscess, generalized peritonitis, or less than a 1-year follow-up. The primary outcome was the rate of failure of nonoperative management within the index admission. Secondary outcomes included the rate of failure of nonoperative management within the first year and risk factors for failure. Results: A total of 810 patients were recruited across 69 European and South American centers; 744 patients (92%) were treated nonoperatively, and 66 (8%) underwent immediate surgery. Baseline characteristics were similar between groups. Hinchey II-IV on diagnostic imaging was the only independent risk factor for surgical intervention during index admission (odds ratios: 12.5, 95% CI: 2.4-64, P =0.003). Among patients treated nonoperatively, at index admission, 697 (94%) patients were discharged without any complications, 35 (4.7%) required emergency surgery, and 12 (1.6%) percutaneous drainage. Free pericolic fluid on CT scan was associated with a higher risk of failure of nonoperative management (odds ratios: 4.9, 95% CI: 1.2-19.9, P =0.023), with 88% of success compared to 96% without free fluid ( P <0.001). The rate of treatment failure with nonoperative management during the first year of follow-up was 16.5%. Conclusion: Patients with AD presenting with pericolic free gas can be successfully managed nonoperatively in the vast majority of cases. Patients with both free pericolic gas and free pericolic fluid on a CT scan are at a higher risk of failing nonoperative management and require closer observation