21 research outputs found
Effect of frequent ventricular ectopia on progression of dilated cardiomyopathy
Dilated cardiomyopathy (DCM) is the most common form of cardiomyopathy. Various conditions may result in DCM, most commonly ischemic heart disease, metabolic/infiltrative diseases and genetic disorders. There are approximately 50 different genes known that cause DCM. Most affected genes are TTN that encode titin. DCM may lead to various rhythmic disorders, especially sustained ventricular tachycardia and ventricular fibrillation. In this article we present a case of 61 years old patient with primary dilated cardiomyopathy who was addmited to our hospital due to acute heart failure. Earlier genetic analysis showed that patient has mutation for titin, protein that is responsible for passive elasticity of caridac smooth muscle cells. Due to two episodes of ventricular tachycarida the ablation was performed, after which implantable cardioverter-defibrillator (ICD) was inserted for primary prevention of further malignant ventricular tachyarrhythmias. Hemodynamic properties and poor left ventricular systolic function were corrected by using optimal medical therapy like eplerenone and sacubitril/valsartan. Patient has developed coronary heart disease and percutaneous coronary intervention was performed with stent implantation. Because of still present ventricular ectopic which lead to further myocardial dysfunction and progression of heart failure, additional ablation is needed. Dilated cardiomyopathy is important cause of heart failure and sudden cardiac death (SCD), especially in young individuals. It is of great importance to recognize and treat it adequately, and also to detect possible cause of it. Further investigetions should be done in order to improve treatment for heart failure that will enhance left ventricular systolic function
Presbyopia Correction During Cataract Surgery with Multifocal Intraocular Lenses
Introduction: The first generations of multifocal intraocular lenses (MFIOLs) were designed to provide patients good distance and near vision, but intermediate was not satisfactory. Trifocal, a bifocal of low-add and quadrifocal MFIOLs were invented, offering possibility to correct vision for distance, near, and intermediate tasks. The novel IOL, extended range of vision (EROV), is covering mostly intermediate and distance vision, with lower level of photic phenomena
Aortic Stenosis
Aortalna stenoza (AS) suženje je uÅ”Äa aorte koje može biti priroÄeno ili steÄeno, a incidencija raste s dobi. Bikuspidalna aortalna valvula Äesto je udružena s drugim srÄanim i aortalnim greÅ”kama. Bolesnici mogu biti kliniÄki asimptomatski ili simptomatski (uglavnom u uznapredovaloj fazi). U procjeni težine aortalne stenoze osim ultrazvuka srca izvode se ergometrija, MSCT i MR srca. Vrlo je važno dobro procijeniti stupanj aortalne stenoze, osobito kod niskoga transvalvularnoga gradijenta. Zamjena aortalne valvule može biti kirurÅ”ka (bioloÅ”ki ili mehaniÄki zalistak) ili manje invazivna, transkateterska (TAVI).Aortic stenosis (AS) is a narrowing of the aortic valves. AS can be congenital or acquired, and the incidence increases with age. Bicuspid aortic valve is often associated with other cardiac and aortic anomalies. Clinically, patients can be asymptomatic or symptomatic (mainly in advanced stage). Echocardiography, exercise test, MSCT and MR are non-invasive methods of choice. Assessment of stenosis severity is very important, especially in low transvalvular gradient. Surgical valve replacement is performed with biological or mechanical valves; another, less invasive method is transcatheter aortic replacement (TAVI)
Analiza Ŕirenja pukotine u strojarskim konstrukcijama
U radu je izvrÅ”ena eksperimentalna analiza Å”irenja pukotine kod Äelika DIN 42CrMo4V. Ovaj materijal u poboljÅ”anom stanju ima visoku ÄvrstoÄu i žilavost. Koristi se za statiÄki i dinamiÄki optereÄene konstrukcijske dijelove, posebno za veÄe presjeke s visokim optereÄenjem. Cilj rada je pronaÄi moguÄnost Å”to toÄnijeg i preciznijeg eksperimentalnog odreÄivanja karakteristika pukotine kod trodimenzijskih problema mehanike loma. IzraÄene su epruvete sa zarezom s iniciranom greÅ”kom tipa pukotine u cilju odreÄivanja udarnih svojstava i parametara mehanike loma. Ova ispitivanja omoguÄuju uspostavljanje ovisnosti geometrije pokretne pukotine i uvjeta naprezanja za njeno daljnje Å”irenje. Time je moguÄe odrediti iznose parametara koji opisuju ponaÅ”anje materijala, kako u linearno-elastiÄnoj tako i u elasto-plastiÄnoj mehanici loma
Combined atrial septal defect and pulmonic stenosis in an adult patient
Atrijski septalni defekt (ASD) u kombinaciji sa stenozom pluÄne arterije (PS) rijedak je u odraslih bolesnika. U zadnje vrijeme poveÄava se broj izvjeÅ”taja o perkutanome lijeÄenju ovih dvaju poremeÄaja jer je dokazano da su uÄinkoviti i izvedivi.
Ovdje se prikazuje sluÄaj odrasloga bolesnika s teÅ”kim PS-om povezanim s ASD-om, koji je lijeÄen kirurÅ”ki zbog nepovoljne anatomije koja je onemoguÄila perkutano lijeÄenje.Atrial septal defect (ASD) combined with pulmonic stenosis (PS) is a relatively uncommon condition in adult patients. Recently, reports on percutaneous therapy of PS and ASD have increased, since percutaneous therapy has been demonstrated to be effective as well as feasible.
This report is about an adult patient with severe PS and associated ASD, who was treated surgically because of unfavourable anatomy which precluded the use of a percutaneous device