173 research outputs found
Holographic Superconductors
A holographic model of superconductors based on the action proposed by
Benini, Herzog, and Yarom [arXiv:1006.0731] is studied. This model has a
charged spin two field in an AdS black hole spacetime. Working in the probe
limit, the normalizable solution of the spin two field in the bulk gives rise
to a superconducting order parameter at the boundary of the AdS. We
calculate the fermion spectral function in this\ superconducting background and
confirm the existence of fermi arcs for non-vanishing Majorana couplings. By
changing the relative strength of the and condensations, the
position and the size of the fermi arcs are changed. When , the
spectrum becomes isotropic and the spectral function is s-wave like. By
changing the fermion mass, the fermi momentum is changed. We also calculate the
conductivity for these holographic superconductors where time reversal
symmetry has been broken spontaneously. A non-vanishing Hall conductivity is
obtained even without an external magnetic field.Comment: 24 pages,17 figures, Add more discussions on hall conductivity, two
new figures, Matched with published versio
Stimulated emission of polarization-entangled photons
Entangled photon pairs -- discrete light quanta that exhibit non-classical
correlations -- play a crucial role in quantum information science (for example
in demonstrations of quantum non-locality and quantum cryptography). At the
macroscopic optical field level non-classical correlations can also be
important, as in the case of squeezed light, entangled light beams and
teleportation of continuous quantum variables. Here we use stimulated
parametric down-conversion to study entangled states of light that bridge the
gap between discrete and macroscopic optical quantum correlations. We
demonstrate experimentally the onset of laser-like action for entangled
photons. This entanglement structure holds great promise in quantum information
science where there is a strong demand for entangled states of increasing
complexity.Comment: 5 pages, 4 figures, RevTeX
Diffractive Higgs Production by AdS Pomeron Fusion
The double diffractive Higgs production at central rapidity is formulated in
terms of the fusion of two AdS gravitons/Pomerons first introduced by Brower,
Polchinski, Strassler and Tan in elastic scattering. Here we propose a simple
self-consistent holographic framework capable of providing phenomenologically
compelling estimates of diffractive cross sections at the LHC. As in the
traditional weak coupling approach, we anticipate that several phenomenological
parameters must be tested and calibrated through factorization for a
self-consistent description of other diffractive process such as total cross
sections, deep inelastic scattering and heavy quark production in the central
region.Comment: 53 pages, 8 figure
Semi-Holographic Fermi Liquids
We show that the universal physics of recent holographic non-Fermi liquid
models is captured by a semi-holographic description, in which a dynamical
boundary field is coupled to a strongly coupled conformal sector having a
gravity dual. This allows various generalizations, such as a dynamical exponent
and lattice and impurity effects. We examine possible relevant deformations,
including multi-trace terms and spin-orbit effects. We discuss the matching
onto the UV theory of the earlier work, and an alternate description in which
the boundary field is integrated out.Comment: 26 pages, 4 figures; v2: typos corrected and report number adde
Semi-local quantum liquids
Gauge/gravity duality applied to strongly interacting systems at finite
density predicts a universal intermediate energy phase to which we refer as a
semi-local quantum liquid. Such a phase is characterized by a finite spatial
correlation length, but an infinite correlation time and associated nontrivial
scaling behavior in the time direction, as well as a nonzero entropy density.
For a holographic system at a nonzero chemical potential, this unstable phase
sets in at an energy scale of order of the chemical potential, and orders at
lower energies into other phases; examples include superconductors and
antiferromagnetic-type states. In this paper we give examples in which it also
orders into Fermi liquids of "heavy" fermions. While the precise nature of the
lower energy state depends on the specific dynamics of the individual system,
we argue that the semi-local quantum liquid emerges universally at intermediate
energies through deconfinement (or equivalently fractionalization). We also
discuss the possible relevance of such a semi-local quantum liquid to heavy
electron systems and the strange metal phase of high temperature cuprate
superconductors.Comment: 31 pages, 7 figure
Holographic Conductivity in Disordered Systems
The main purpose of this paper is to holographically study the behavior of
conductivity in 2+1 dimensional disordered systems. We analyze probe D-brane
systems in AdS/CFT with random closed string and open string background fields.
We give a prescription of calculating the DC conductivity holographically in
disordered systems. In particular, we find an analytical formula of the
conductivity in the presence of codimension one randomness. We also
systematically study the AC conductivity in various probe brane setups without
disorder and find analogues of Mott insulators.Comment: 43 pages, 28 figures, latex, references added, minor correction
Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue.
E-cadherin-mediated cell-cell junctions play a prominent role in maintaining the epithelial architecture. The disruption or deregulation of these adhesions in cancer can lead to the collapse of tumor epithelia that precedes invasion and subsequent metastasis. Here we generated an E-cadherin-GFP mouse that enables intravital photobleaching and quantification of E-cadherin mobility in live tissue without affecting normal biology. We demonstrate the broad applications of this mouse by examining E-cadherin regulation in multiple tissues, including mammary, brain, liver, and kidney tissue, while specifically monitoring E-cadherin mobility during disease progression in the pancreas. We assess E-cadherin stability in native pancreatic tissue upon genetic manipulation involving Kras and p53 or in response to anti-invasive drug treatment and gain insights into the dynamic remodeling of E-cadherin during in situ cancer progression. FRAP in the E-cadherin-GFP mouse, therefore, promises to be a valuable tool to fundamentally expand our understanding of E-cadherin-mediated events in native microenvironments
The Effect of Raltegravir Intensification on Low-level Residual Viremia in HIV-Infected Patients on Antiretroviral Therapy: A Randomized Controlled Trial
In a double-blind trial, Rajesh Gandhi and colleagues detect no significant reduction in viral load after people with low-level HIV viremia added an integrase inhibitor to their treatment regimen
Circadian Modulation of Gene Expression, but not Glutamate Uptake, in Mouse and Rat Cortical Astrocytes
Circadian clocks control daily rhythms including sleep-wake, hormone secretion, and metabolism. These clocks are based on intracellular transcription-translation feedback loops that sustain daily oscillations of gene expression in many cell types. Mammalian astrocytes display circadian rhythms in the expression of the clock genes Period1 (Per1) and Period2 (Per2). However, a functional role for circadian oscillations in astrocytes is unknown. Because uptake of extrasynaptic glutamate depends on the presence of Per2 in astrocytes, we asked whether glutamate uptake by glia is circadian.We measured glutamate uptake, transcript and protein levels of the astrocyte-specific glutamate transporter, Glast, and the expression of Per1 and Per2 from cultured cortical astrocytes and from explants of somatosensory cortex. We found that glutamate uptake and Glast mRNA and protein expression were significantly reduced in Clock/Clock, Per2- or NPAS2-deficient glia. Uptake was augmented when the medium was supplemented with dibutyryl-cAMP or B27. Critically, glutamate uptake was not circadian in cortical astrocytes cultured from rats or mice or in cortical slices from mice.We conclude that glutamate uptake levels are modulated by CLOCK, PER2, NPAS2, and the composition of the culture medium, and that uptake does not show circadian variations
A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts.
The small GTPase RhoA is involved in a variety of fundamental processes in normal tissue. Spatiotemporal control of RhoA is thought to govern mechanosensing, growth, and motility of cells, while its deregulation is associated with disease development. Here, we describe the generation of a RhoA-fluorescence resonance energy transfer (FRET) biosensor mouse and its utility for monitoring real-time activity of RhoA in a variety of native tissues in vivo. We assess changes in RhoA activity during mechanosensing of osteocytes within the bone and during neutrophil migration. We also demonstrate spatiotemporal order of RhoA activity within crypt cells of the small intestine and during different stages of mammary gestation. Subsequently, we reveal co-option of RhoA activity in both invasive breast and pancreatic cancers, and we assess drug targeting in these disease settings, illustrating the potential for utilizing this mouse to study RhoA activity in vivo in real time
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