5 research outputs found
History Shaped the Geographic Distribution of Genomic Admixture on the Island of Puerto Rico
- Author
- A Auton
- A Getis
- A Piazza
- AS Fotheringham
- BM Henn
- CC Gravlee
- CH Arce
- Christopher R. Gignoux
- D Falush
- E Gelpí Baíz
- E Gonzalez Burchard
- E Telles
- EH Isaaks
- Elad Ziv
- EM John
- Esteban González Burchard
- F Moscoso
- FM Salzano
- G Bedoya
- Gladys Toro-Labrador
- HS Klein
- I Silva-Zolezzi
- J Marchini
- J Novembre
- JC Florez
- JC Martinez-Cruzado
- JC Martinez-Cruzado
- JH Relethford
- JK Pritchard
- John Relethford
- Jorge Viera-Vera
- Joshua Galanter
- JP Sanger
- Juan Carlos Martínez-Cruzado
- K Bryc
- K Bryc
- Kenneth Beckman
- Laura Fejerman
- LG Mullineaux
- Lindsey A. Roth
- LL Cavalli-Sforza
- LM Díaz Soler
- M Alvarez Nazario
- M Huizing
- MA Abdulla
- Marc Via
- N Risch
- NA Ellis
- Neil Risch
- P Menozzi
- PAP Moran
- PT de Córdoba
- R King
- R Yaeger
- S Choudhry
- S Choudhry
- S Wang
- Shweta Choudhry
- SW Mintz
- T Caulfield
- Taras K. Oleksyk
- V Stolcke
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
Contemporary genetic variation among Latin Americans human groups reflects population migrations shaped by complex historical, social and economic factors. Consequently, admixture patterns may vary by geographic regions ranging from countries to neighborhoods. We examined the geographic variation of admixture across the island of Puerto Rico and the degree to which it could be explained by historic and social events. We analyzed a census-based sample of 642 Puerto Rican individuals that were genotyped for 93 ancestry informative markers (AIMs) to estimate African, European and Native American ancestry. Socioeconomic status (SES) data and geographic location were obtained for each individual. There was significant geographic variation of ancestry across the island. In particular, African ancestry demonstrated a decreasing East to West gradient that was partially explained by historical factors linked to the colonial sugar plantation system. SES also demonstrated a parallel decreasing cline from East to West. However, at a local level, SES and African ancestry were negatively correlated. European ancestry was strongly negatively correlated with African ancestry and therefore showed patterns complementary to African ancestry. By contrast, Native American ancestry showed little variation across the island and across individuals and appears to have played little social role historically. The observed geographic distributions of SES and genetic variation relate to historical social events and mating patterns, and have substantial implications for the design of studies in the recently admixed Puerto Rican population. More generally, our results demonstrate the importance of incorporating social and geographic data with genetics when studying contemporary admixed populations
Biogeographical Survey Identifies Consistent Alternative Physiological Optima and a Minor Role for Environmental Drivers in Maintaining a Polymorphism
- Author
- A Cordero Rivera
- A Corl
- A Córdoba-Aguilar
- A Córdoba-Aguilar
- A Iserbyt
- A Iserbyt
- A Iserbyt
- A Iserbyt
- A Iserbyt
- A Nakamoto
- A Wong
- A Wong
- AE Magurran
- Arne Iserbyt
- B Calsbeek
- B Pujol
- B Sinervo
- B Sinervo
- B Sinervo
- BB Li
- Bengt Hansson
- BON Hinnekint
- CK Cornwallis
- CM Lessells
- D González-Tokman
- D Punzalan
- D Wheeler
- DE Farrar
- DJ Fielding
- E Lam
- E Svensson
- EA Hoffman
- EG Bligh
- EG King
- EI Svensson
- EI Svensson
- EI Svensson
- G De'ath
- G Joop
- H Kokko
- H Sugumaran
- H Van Gossum
- H Van Gossum
- H Van Gossum
- H Van Gossum
- H Van Gossum
- H Zheng
- Hans Van Gossum
- HM Lease
- HM Robertson
- I González-Santoyo
- I Karl
- IA Cooper
- IJ Saccheri
- J Bots
- J Bots
- J Rolff
- J Rolff
- J Silvertown
- J Stapley
- JA Andrés
- JA Andrés
- JA Endler
- JF Le Galliard
- JH Marden
- JH Marden
- JK Abbott
- JL Locklin
- JS Jones
- JS McKinnon
- K Berwaerts
- K Kunte
- K Olsson
- KF Conrad
- L Excoffier
- LM Mullen
- M De Block
- M Hammers
- M Hubert
- M Phifer-Rixey
- M Slatkin
- MC Whitlock
- MD Abramoff
- MJ Westfall
- MM Bradford
- MRL Forbes
- MRL Forbes
- MT Siva-Jothy
- MZ Xu
- N Bouton
- N Ohsaki
- OM Fincke
- P Nosil
- P Schmid-Hempel
- PS Corbet
- PT Mucklow
- R Calsbeek
- R Calsbeek
- R Parkash
- R Stoks
- R Stoks
- R Ziegler
- RA Sánchez-Guillén
- RA Sánchez-Guillén
- RK Boughton
- RL Lochmiller
- RL Millstein
- Robby Stoks
- S Antoniazza
- S Holm
- SC Stearns
- SM Gray
- T Leinonen
- TP Gosden
- TP Gosden
- WD Koenig
- Y Takahashi
- Y Takahashi
- Z Zhao
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2012
- Field of study
The contribution of adaptive mechanisms in maintaining genetic polymorphisms is still debated in many systems. To understand the contribution of selective factors in maintaining polymorphism, we investigated large-scale (>1000 km) geographic variation in morph frequencies and fitness-related physiological traits in the damselfly Nehalennia irene. As fitness-related physiological traits, we investigated investment in immune function (phenoloxidase activity), energy storage and fecundity (abdomen protein and lipid content), and flight muscles (thorax protein content). In the first part of the study, our aim was to identify selective agents maintaining the large-scale spatial variation in morph frequencies. Morph frequencies varied considerably among populations, but, in contrast to expectation, in a geographically unstructured way. Furthermore, frequencies co-varied only weakly with the numerous investigated ecological parameters. This suggests that spatial frequency patterns are driven by stochastic processes, or alternatively, are consequence of highly variable and currently unidentified ecological conditions. In line with this, the investigated ecological parameters did not affect the fitness-related physiological traits differently in both morphs. In the second part of the study, we aimed at identifying trade-offs between fitness-related physiological traits that may contribute to the local maintenance of both colour morphs by defining alternative phenotypic optima, and test the spatial consistency of such trade-off patterns. The female morph with higher levels of phenoloxidase activity had a lower thorax protein content, and vice versa, suggesting a trade-off between investments in immune function and in flight muscles. This physiological trade-off was consistent across the geographical scale studied and supports widespread correlational selection, possibly driven by male harassment, favouring alternative trait combinations in both female morphs
Role of Factor H Binding Protein in Neisseria meningitidis Virulence and Its Potential as a Vaccine Candidate To Broadly Protect against Meningococcal Disease
- Author
- Ala'aldeen DA
- Anderson A
- Anderson AS
- Anderson AS
- Artenstein MS
- Artenstein MS
- Beernink PT
- Beernink PT
- Bernfield L
- Bruge J
- Brunelli B
- Cantini F
- Cartwright K
- Cendron L
- Christensen H
- Cohn AC
- DiScipio RG
- Emonts M
- English M
- Farley J
- Frasch CE
- Gold R
- Gorringe AR
- Gossger N
- Hao W
- Haralambous E
- Harris SL
- Healy CM
- Jacobsson S
- Jiang HQ
- Kazatchkine MD
- Keiser PB
- Keiser PB
- Knuf M
- Koeberling O
- Kraiczy P
- Lambris JD
- Litt D
- Lo H
- MacLennan JM
- Macneil JR
- Maiden MCJ
- Marsh JW
- Marshall HS
- Mascioni A
- Mascioni A
- McNeil LK
- McNeil LK
- McNeil LK
- Pajon R
- Pangburn MK
- Pangburn MK
- Pichichero M
- Pillai S
- Pio R
- Richmond PC
- Richmond PC
- Rodríguez de Córdoba S
- Rosenstein NE
- Santolaya ME
- Scarselli M
- Schwarz R
- Seib KL
- Sheldon EA
- Snape MD
- Snyder LAS
- Stokley S
- Toneatto D
- Trotter CL
- Vu DM
- Vu DM
- Vu DM
- Welsch JA
- Welsch JA
- Wilder-Smith A
- Wright V
- Wu HC
- Wyle FA
- Zhu D
- Zipfel PF
- Publication venue
- 'American Society for Microbiology'
- Publication date
- Field of study
Distributional patterns of Aptian-Albian paleoichthyofauna of Brazil and Africa based on Track Analysis
- Author
- AGASSIZ L.
- ALA MA
- ALVARADO-ORTEGA J
- AMARAL CRL
- ANDERSON PE
- ARAI M.
- ARAMBOURG CE
- ASSINE ML.
- AZEVEDO RLM.
- BOUAZIZ S
- BRITO PM
- BRITO PM
- BRITO PM
- BRITO PM
- BRITO PM
- BRITO PM
- BRITO PM.
- CANDEIRO CRA
- CARVALHO CJB
- CARVALHO MSS
- CASIER E.
- CASTRO DF
- CAVIN L
- CHANG HK
- COSTA IP
- COSTA IP
- CRAW RC
- CRISCI JV.
- CROIZAT L.
- CROIZAT L.
- CUNY G
- CUNY G
- CÓRDOBA VC
- EASTMAN CR.
- FIGUEIREDO FJ
- FIGUEIREDO FJ
- FIGUEIREDO FJ.
- FIGUEIREDO FJ.
- FIGUEIREDO FJ.
- FOREY PL
- FRANCISCO J. DE FIGUEIREDO
- GALLO V
- GALLO V
- GALLO V
- GAYET M.
- GEE H.
- GOTTFRIED MD
- GRANDE L.
- GREHAN JR
- GREIGERT J.
- HAY WW
- HEADS M.
- HERBERT TD
- HILDA M.A. DA SILVA
- JORDAN DS
- JORDAN DS.
- JORDAN DS.
- KOERBER S.
- LEFRANC JP.
- LUNDBERG J.
- MAISEY JG.
- MAISEY JG.
- MAISEY JG.
- MALABARBA MCSL
- MARTILL DM
- MARTILL DM
- MAYRINCK D
- MIGUEL R
- MOODY RTJ
- MORRONE JJ
- MORRONE JJ.
- MORRONE JJ.
- MURRAY AM.
- NETO OCP
- NETO OPAC
- PLESTCH T
- POPOFF M.
- RAMOS MIF
- ROBERTS EM
- ROJAS CA.
- SANTOS MECM
- SARAIVA AAF.
- SCHAEFFER B.
- SCOTESE CR.
- SILVA HMA
- SILVA SANTOS R.
- SILVA SANTOS R.
- SILVA SANTOS R.
- SILVA SANTOS R.
- SILVA SANTOS R.
- SILVA SANTOS R.
- SILVA SANTOS R.
- SOUZA-LIMA W
- SOUZA-LIMA W.
- SOUZA-LIMA W.
- SZATMARI P
- TAVERNE L
- TAVERNE L.
- THAÍS C.C. PARMÉRA
- TOLEDO CEV
- UPCHURCH P.
- VALÉRIA GALLO
- VAZ PT
- WENZ S
- WENZ S
- WENZ S
- WENZ S.
- WOODWARD AS.
- ZALÁN PV
- ZALÁN PV.
- ZARBOUT M
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- 01/01/2019
- Field of study
Retinal Glia
- Author
- Aaby AA
- Abbracchio MP
- Abdul Y
- Abrahan CE
- Abu-El-Asrar AM
- Abu-El-Asrar AM
- Abu-El-Asrar AM
- Abu-El-Asrar AM
- Abukawa H
- Acosta ML
- Adamis AP
- Adamus G
- Ader M
- Adler R
- Agapova OA
- Agardh E
- Agarwal N
- Agca C
- Agostinho P
- Agre P
- Agte S
- Agulhon C
- Ahmad I
- Ahmad I
- Ahmad I
- Ahmad S
- Ahmed J
- Aiello LP
- Aiello LP
- Aiello LP
- Akaishi K
- Akanuma S
- Akiyama H
- Akmayev IG
- Akopian A
- Al-Gayyar MM
- Alberghina M
- Albini TA
- Albrecht J
- Albrecht J
- Alder VA
- Ali BH
- Ali TK
- Allen NJ
- Alon T
- Alvaro AR
- Amaratunga A
- Amato A
- Ambati J
- Ames A
- Ames A
- Amin RH
- Anccasi RM
- Anderson DH
- Anderson DH
- Anderson DH
- Anderson DH
- Anderson DR
- Anderson PJ
- Ando D
- Ando N
- Andrade da Costa BL
- Andrade da Costa BLS
- Andrews A
- Andrés N
- Anezary L
- Angel P
- Angénieux B
- Ankerhold R
- Antcliff RJ
- Antcliff RJ
- Anthony T
- Antonetti DA
- Antoniades HN
- Arai-Gaun S
- Archer SN
- Ard MD
- Arenzana FJ
- Armson PF
- Armstrong D
- Arnold TD
- Arora PD
- Arrindell EL
- Arroba AI
- Arroba AI
- Arsenijevic Y
- Arunchaipong K
- Asai N
- Asano T
- Ash J
- Ashton N
- Ashwell K
- Ashwell KW
- Asnaghi V
- Atsuzawa K
- Auguste KI
- Avidan H
- Avraham-Lubin BC
- Avwenagha O
- Aymerich MS
- Baas D
- Badaut J
- Baehr M
- Bai Y
- Bai Y
- Bai Y
- Bailey TJ
- Bakalash S
- Baker JG
- Balasubramaniam B
- Balboa MA
- Ball AK
- Balse E
- Banati RB
- Bandtlow CE
- Bannai S
- Baptiste DC
- Baptiste DC
- Barber AJ
- Barbour B
- Barbour B
- Barbour B
- Barbour B
- Barcelona PF
- Barcelona PF
- Barcelona PF
- Bargagna-Mohan P
- Barile GR
- Barker AJ
- Barmack NH
- Barnes S
- Barnett NL
- Barnett NL
- Barnett NL
- Barnett NL
- Barouch FC
- Barres BA
- Barres BA
- Barron KD
- Bartsch U
- Bartsch U
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- Bastmeyer M
- Battista AG
- Bauch H
- Bauer B
- Bauer B
- Baumbach GL
- Bay V
- Baydas G
- Bazan JF
- Beale R
- Beard ME
- Beart PM
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- Belmonte KE
- Beltran WA
- Ben-Dror I
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- Benson MT
- Beretta S
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- Berger UV
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- Berko-Flint Y
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- Bernardos RL
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- Bhatia B
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- Bialas AR
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- Bozard BR
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- Breckler J
- Bresnick GH
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- Broderick C
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- Bromberg JS
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- Brooks DE
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- Brändle D
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- Burke JM
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- Burns MS
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- Büchi ER
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- Büssow H
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- Cadelli DS
- Cai D
- Caicedo A
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- Chem
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- Colafrancesco V
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- Comp Neurol
- Condon GP
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- Conner JD
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- Corbett JA
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- Djamgoz MB
- Dkhissi O
- Dmitriev AV
- Dmitriev AV
- Do Carmo A
- Dong N
- Dorey CK
- Dorfman D
- Dorfman D
- Dorrell MI
- Dos Santos-Rodrigues A
- Douglas MR
- Downie LE
- Drechsler F
- Dreher Z
- Dreher Z
- Dreher Z
- Drenckhahn D
- Drescher KM
- Drescher KM
- Drescher KM
- Drexler W
- Dreyer EB
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- Dräger UC
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- Du Y
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- Dubois RN
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- Dudek FE
- Duguid IGM
- Duh EJ
- Duh EJ
- Duke-Elder S
- Duke-Elder S.
- Dun Y
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- Dvoriantchikova G
- Dvoriantchikova G
- Dworetzky SI
- Dyer MA
- Dykens JA
- Dünker N
- Easter
- Eaton MJ
- Eaton MJ
- Eberhardt C
- Eberhardt W
- Ebert S
- Ebneter A
- Echevarria F
- Echevarria M
- Eckes B
- Eddleston M
- Edelman JL
- Eder C
- Edqvist PH
- Edwards JR
- Edwards MM
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- Egensperger R
- Ehinger B
- Ehinger B
- Ehrenberg M
- Eichler W
- Eichler W
- Eichler W
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- Eichler W
- Eichner D
- Eisenfeld AJ
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- Ekström P
- El-Asrar AM
- El-Ghrably IA
- El-Ghrably IA
- El-Remessy AB
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- El-Sherbeny A
- Eliasof S
- Eliasof S
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- Elsherbiny NM
- Emerson
- Engelhardt M
- Enger R
- Engerman RL
- Enoch JM
- Erickson PA
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- Esche M
- Esguerra M
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- Ibrahim AS
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