7 research outputs found
Design of two series of 1:1 cocrystals involving 4-amino-5-chloro-2,6-dimethylpyrimidine and carboxylic acids
© 2018 International Union of Crystallography. Two series of a total of ten cocrystals involving 4-amino-5-chloro-2,6-dimethyl-pyrimidine with various carboxylic acids have been prepared and characterized by single-crystal X-ray diffraction. The pyrimidine unit used for the cocrystals offers two ring N atoms (positions N1 and N3) as proton-accepting sites. Depending upon the site of protonation, two types of cations are possible [Rajam et al. (2017). Acta Cryst. C73, 862â868]. In a parallel arrangement, two series of cocrystals are possible depending upon the hydrogen bonding of the carboxyl group with position N1 or N3. In one series of cocrystals, i.e. 4-amino-5-chloro-2,6-dimethylpyrimidineâ3-bromothiophene-2-carboxylic acid (1/1), 1, 4-amino-5-chloro-2,6-dimethylpyrimidineâ5-chlorothiophene-2-carboxylic acid (1/1), 2, 4-amino-5-chloro-2,6-dimethylpyrimidineâ2,4-dichlorobenzoic acid (1/1), 3, and 4-amino-5-chloro-2,6-dimethylpyrimidineâ2-aminobenzoic acid (1/1), 4, the carboxyl hydroxy group (âOH) is hydrogen bonded to position N1 (OâHâŠN1) of the corresponding pyrimidine unit (single point supramolecular synthon). The inversion-related stacked pyrimidines are doubly bridged by the carboxyl groups via NâHâŠO and OâHâŠN hydrogen bonds to form a large cage-like tetrameric unit with an R24(20) graph-set ring motif. These tetrameric units are further connected via base pairing through a pair of NâHâŠN hydrogen bonds, generating R22(8) motifs (supramolecular homosyn-thon). In the other series of cocrystals, i.e. 4-amino-5-chloro-2,6-dimethyl-pyrimidineâ5-methylthiophene-2-carboxylic acid (1/1), 5, 4-amino-5-chloro-2,6-dimethylpyrimidineâbenzoic acid (1/1), 6, 4-amino-5-chloro-2,6-dimethylpyrimi-dineâ2-methylbenzoic acid (1/1), 7, 4-amino-5-chloro-2,6-dimethylpyrimidineâ 3-methylbenzoic acid (1/1), 8, 4-amino-5-chloro-2,6-dimethylpyrimidineâ 4-methylbenzoic acid (1/1), 9, and 4-amino-5-chloro-2,6-dimethylpyrimidineâ 4-aminobenzoic acid (1/1), 10, the carboxyl group interacts with position N3 and the adjacent 4-amino group of the corresponding pyrimidine ring via OâHâŠN and NâHâŠO hydrogen bonds to generate the robust R22(8) supramolecular heterosynthon. These heterosynthons are further connected by NâHâŠN hydrogen-bond interactions in a linear fashion to form a chain-like arrangement. In cocrystal 1, a BrâŠBr halogen bond is present, in cocrystals 2 and 3, ClâŠCl halogen bonds are present, and in cocrystals 5, 6 and 7, ClâŠO halogen bonds are present. In all of the ten cocrystals, ÏâÏ stacking interactions are observed