372 research outputs found
Instability of black hole formation under small pressure perturbations
We investigate here the spectrum of gravitational collapse endstates when
arbitrarily small perfect fluid pressures are introduced in the classic black
hole formation scenario as described by Oppenheimer, Snyder and Datt (OSD) [1].
This extends a previous result on tangential pressures [2] to the more
physically realistic scenario of perfect fluid collapse. The existence of
classes of pressure perturbations is shown explicitly, which has the property
that injecting any smallest pressure changes the final fate of the dynamical
collapse from a black hole to a naked singularity. It is therefore seen that
any smallest neighborhood of the OSD model, in the space of initial data,
contains collapse evolutions that go to a naked singularity outcome. This gives
an intriguing insight on the nature of naked singularity formation in
gravitational collapse.Comment: 7 pages, 1 figure, several modifications to match published version
on GR
Corneal topographic changes in premenopausal and postmenopausal women
<p>Abstract</p> <p>Background</p> <p>To asses the effect of menopause on the corneal curvature changes using corneal computerized videokeratography (CVK) in premenopausal and postmenopausal healthy women.</p> <p>Methods</p> <p>Thirty-six postmenopausal women with mean ages of 49.2 (range 39 to 57) were enrolled in this randomized, prospective study, comparing with 26 healthy controls with mean ages of 38.5 +/- 4.9 (range 32 to 49). Subjects were determined to be postmenopausal, by the Gynecology and Obstetrics Department, based on blood Follicular Stimulating Hormone (FSH), Luteinizing Hormone (LH), Estradiol, Progesterone levels and clinical complaints. Complete ophthalmic examination and CVK using Haag-Streit System was performed in both premenopausal and postmenopausal women.</p> <p>Results</p> <p>Mean horizontal curvature and vertical curvature of central corneal power in premenopausal women were 43.5 +/- 1.25 Diopter (D), and 44.1 +/- 1.53 D. Mean horizontal curvature and vertical curvature of central corneal power in postmenopausal women were 43.9 +/- 1.4 D, and 44.6 +/- 1.3 D. The mean keratometric astigmatisms of premenopausal and postmenopausal women were 0.81 +/- 0.57 D (4–179 degrees), 0.74 degrees +/- 0.5 D (1–180 degrees) respectively. No significant corneal curvature changes were detected between premenopausal and postmenopausal groups (P > 0.05). On the other hand, we only found negative but significant correlation between horizontal corneal curvature and estrogen level of postmenopausal women (r = -0.346, p = 0.038).</p> <p>Conclusion</p> <p>Menopause is physiologic process and may also affect corneal topographic changes. In postmenopausal women, corneal steeping was observed minimally compared to premenopausal women. The results suggest that changes in estrogen level of women with menopause are associated with slightly alteration of horizontal curvature of cornea.</p
Gravitational collapse with tachyon field and barotropic fluid
A particular class of space-time, with a tachyon field, \phi, and a
barotropic fluid constituting the matter content, is considered herein as a
model for gravitational collapse. For simplicity, the tachyon potential is
assumed to be of inverse square form i.e., V(\phi) \sim \phi^{-2}. Our purpose,
by making use of the specific kinematical features of the tachyon, which are
rather different from a standard scalar field, is to establish the several
types of asymptotic behavior that our matter content induces. Employing a
dynamical system analysis, complemented by a thorough numerical study, we find
classical solutions corresponding to a naked singularity or a black hole
formation. In particular, there is a subset where the fluid and tachyon
participate in an interesting tracking behaviour, depending sensitively on the
initial conditions for the energy densities of the tachyon field and barotropic
fluid. Two other classes of solutions are present, corresponding respectively,
to either a tachyon or a barotropic fluid regime. Which of these emerges as
dominant, will depend on the choice of the barotropic parameter, \gamma.
Furthermore, these collapsing scenarios both have as final state the formation
of a black hole.Comment: 18 pages, 7 figures. v3: minor changes. Final version to appear in
GR
CTLA-4 Activation of Phosphatidylinositol 3-Kinase (PI 3-K) and Protein Kinase B (PKB/AKT) Sustains T-Cell Anergy without Cell Death
The balance of T-cell proliferation, anergy and apoptosis is central to immune function. In this regard, co-receptor CTLA-4 is needed for the induction of anergy and tolerance. One central question concerns the mechanism by which CTLA-4 can induce T-cell non-responsiveness without a concurrent induction of antigen induced cell death (AICD). In this study, we show that CTLA-4 activation of the phosphatidylinositol 3-kinase (PI 3-K) and protein kinase B (PKB/AKT) sustains T-cell anergy without cell death. CTLA-4 ligation induced PI 3K activation as evidenced by the phosphorylation of PKB/AKT that in turn inactivated GSK-3. The level of activation was similar to that observed with CD28. CTLA-4 induced PI 3K and AKT activation also led to phosphorylation of the pro-apoptotic factor BAD as well as the up-regulation of BcL-XL. In keeping with this, CD3/CTLA-4 co-ligation prevented apoptosis under the same conditions where T-cell non-responsiveness was induced. This effect was PI 3K and PKB/AKT dependent since inhibition of these enzymes under conditions of anti-CD3/CTLA-4 co-ligation resulted in cell death. Our findings therefore define a mechanism by which CTLA-4 can induce anergy (and possibly peripheral tolerance) by preventing the induction of cell death
Metaheuristics for Transmission Network Expansion Planning
This chapter presents the characteristics of the metaheuristic algorithms used to solve the transmission network expansion planning (TNEP) problem. The algorithms used to handle single or multiple objectives are discussed on the basis of selected literature contributions. Besides the main objective given by the costs of the transmission system infrastructure, various other objectives are taken into account, representing generation, demand, reliability and environmental aspects. In the single-objective case, many metaheuristics have been proposed, in general without making strong comparisons with other solution methods and without providing superior results with respect to classical mathematical programming. In the multi-objective case, there is a better convenience of using metaheuristics able to handle conflicting objectives, in particular with a Pareto front-based approach. In all cases, improvements are still expected in the definition of benchmark functions, benchmark networks and robust comparison criteria
Stochasticity in Protein Levels Drives Colinearity of Gene Order in Metabolic Operons of Escherichia coli
Gene order in some bacterial metabolic operons reflects ordering in the metabolic pathway. That this is true uniquely for operons expressed at low levels highlights the selective importance of fluctuations in protein levels
DECA: distributed energy conservation algorithm for process reconstruction with bounded relative error in wireless sensor networks
Age-dependent expression of Pten and Smad4 genes in the urogenital system of Wistar rats
- …