13 research outputs found
The Imaclim-R model: infrastructures, technical inertia and the costs of low carbon futures under imperfect foresight
Enhancing the Shelf Life of Sweet Sorghum [Sorghum bicolor (L.) Moench] Juice Through Pasteurization While Sustaining Fermentation Efficiency
Structural stability of photodegradable poly(l-lactic acid)/PE/TiO2 nanocomposites through TiO2 nanospheres and TiO2 nanotubes incorporation
Metallocene-Catalyzed Copolymerization of Ethylene and 1-Hexene in the Presence of Graphene/MgAl LDH Nanofiller: Effect on the Activity, SCB, and Thermal Stability
Syndiospecific Styrene Polymerization and Ethylene/Styrene Copolymerization Using Half-Titanocenes: Ligand Effects and Some New Mechanistic Aspects
Is there a place and role for endocytic TCR signaling?
International audienceT-lymphocyte activation relies on the cognate recognition by the TCR of the MHC-associated peptide ligand (pMHC) presented at the surface of an antigen-presenting cell (APC). This leads to the dynamic formation of a cognate contact between the T lymphocyte and the APC: the immune synapse (IS). Engagement of the TCR by the pMHC in the synaptic zone induces a cascade of signaling events leading to phosphorylation and dephosphorylation of proteins and lipids, which ultimately shapes the response of T lymphocytes. Although the engagement of the T-cell receptor (TCR) takes place at the plasma membrane, the TCR/CD3 complexes and the signaling molecules involved in transduction of the TCR signal are also present in intracellular membrane pools. These pools, which are both endocytic and exocytic, have tentatively been characterized by several groups including ours. We will herein summarize what is known on the intracellular pools of TCR signaling components. We will discuss their origin and the mechanisms involved in their mobility at the IS. Finally, we will propose several hypotheses concerning the functional role(s) that these intracellular pools might play in T-cell activation. We will also discuss the tools that could be used to test these hypotheses