Alien Registration- Procopio, Dominic A. (South Portland, Cumberland County)

https://digitalmaine.com/alien_docs/20329/thumbnail.jp

Managing the mining cycle using GeoVisionary

Managing the mining cycle from exploration through to evaluation, planning, construction, operation and finally mine closure can involve many datasets in different formats. To be able to visualise all of these different datasets in one environment is important to locate mineral/ore deposits, moderate risks, increase mining efficiency, monitor the impact on the surrounding environment and communicate these factors to stakeholders. Typically, GIS – Geographical Information Systems have been used to manage the life cycle of a mine, however the three dimensional (3D) complexity is lost in these two dimensional (2D) systems. Virtalis alongside the British Geological Survey, have developed the GeoVisionary software which provides the means to aid the management of many aspects of the life cycle of a mine using a combination 2D, 3D and 4D data in the same virtual environment

Multiphysics analyses of the effect of package on the performances of PMUT transducers

The paper deals with the multiphysics modeling of piezoelectric micromachined ultrasound transducers (PMUT), that can be used in several practical applications. The model accounts for the multiple couplings between the mechanical fields and the electric and acoustic ones. The numerical solution has been sought by means of the finite element method, for the special case of axial symmetry. The model has been validated with reference to experimental data, that have been obtained by the Authors. The numerical procedure has been applied to carry out a parametric analysis of the effect of package, to extract a set of design guidelines

The three-body recombination of a condensed Bose gas near a Feshbach resonance

In this paper, we study the three-body recombination rate of a homogeneous dilute Bose gas with a Feshbach resonance at zero temperature. The ground state and excitations of this system are obtained. The three-body recombination in the ground state is due to the break-up of an atom pair in the quantum depletion and the formation of a molecule by an atom from the broken pair and an atom from the condensate. The rate of this process is in good agreement with the experiment on $^{23}$Na in a wide range of magnetic fields.Comment: 10 pages, 2 figures, to be published in Phys. Rev.

DNAJC12 deficiency: Mild hyperphenylalaninemia and neurological impairment in two siblings

Background: DNAJC12 co-chaperone protein deficiency has been recently described as a stand-alone metabolic disorder explaining many cases of mild hyperphenylalaninemia (HPA) that are not caused by variants in the PAH gene, which encodes for the hepatic enzyme phenylalanine hydroxylase (PAH), or inGCH1, PTS, QDPR, PCBD1 and DHPR, involved in tetrahydrobiopterin (BH4) biosynthesis and activity. Results: We describe two sisters born to consanguineous parents. The youngest sister (Patient 1), initially asymptomatic, tested positive at NewBorn Screening (NBS) for mild HPA. After variants in the PAH and BH4 related-genes were excluded, we performed DNAJC12 genetic analysis and found a previously described homozygous deletion [NM_021800.3: c.58_59del p.(Gly20Metfs*2)]. The older sister (Patient 2), homozygous for the same variant and exhibiting mild HPA, was diagnosed subsequently and presented with ataxia and repeated falls, upper limb dyskinesia, intentional tremor, and mild intellectual disability. Patient 1 was started on treatment with low Phenylalanine (Phe) diet, BH4, l-3,4-dihydroxyphenylalanine/carbidopa (L-DOPA) and 5-OH-Tryptophan, soon after diagnosis, and despite poor adherence to the dietary regimen, only manifested language impairment at last follow-up (age 5 years and 4 months). Patient 2, who started the same treatment at school age, experienced a minimal progression of neurological symptoms, with some improvement in her motor skills. Conclusions: These two new patients with DNAJC12-associated HPA, in addition to previous reports, point to DNAJC12 deficiency as a new metabolic syndrome that must be considered in patients with unexplained HPA