Proteomic Biomarkers for Spontaneous Preterm Birth:A Systematic Review of the Literature

This review aimed to identify, synthesize, and analyze the findings of studies on proteomic biomarkers for spontaneous preterm birth (PTB). Three electronic databases (Medline, Embase, and Scopus) were searched for studies in any language reporting the use of proteomic biomarkers for PTB published between January 1994 and December 2012. Retrieved citations were screened, and relevant studies were selected for full-text reading, in triplicate. the search yielded 529 citations, 51 were selected for full-text reading and 8 studies were included in the review. A total of 64 dysregulated proteins were reported. Only 14-3-3 protein sigma, annexin A5, protein S100-A8, protein S100-A12, and inter--trypsin inhibitor heavy chain H4 were reported in more than 1 study, but results could not be combined due to heterogeneity in type of sample and analytical platform. in conclusion, according to the existing literature, there are no specific proteomic biomarkers capable of accurately predicting PTB.Univ Hosp Hradec Kralove, Biomed Res Ctr, Hradec Kralove, Czech RepublicCharles Univ Prague, Fac Med Hradec Kralove, Dept Obstet & Gynecol, Hradec Kralove, Czech RepublicUniv Def, Fac Mil Hlth Sci, Inst Mol Pathol, Hradec Kralove, Czech RepublicHosp Pardubice, Dept Obstet & Gynecol, Pardubice, Czech RepublicOdense Univ Hosp, Dept Obstet & Gynecol, Svendborg, DenmarkUniversidade Federal de São Paulo, Dept Internal Med, São Paulo, BrazilUniv Texas Med Branch, Dept Obstet & Gynecol, Div Maternal Fetal Med & Perinatal Res, Galveston, TX 77755 USAUniversidade Federal de São Paulo, Dept Internal Med, São Paulo, BrazilWeb of Scienc