58 research outputs found

    Large expert-curated database for benchmarking document similarity detection in biomedical literature search

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    Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency–Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research

    High Optical-to-X-Ray Polarization Ratio Reveals Compton Scattering in BL Lacertae’s Jet

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    Blazars, supermassive black hole systems with highly relativistic jets aligned with the line of sight, are the most powerful long-lived emitters of electromagnetic emission in the Universe. We report here on a radio-to-gamma-ray multiwavelength campaign on the blazar BL Lacertae with unprecedented polarimetric coverage from radio to X-ray wavelengths. The observations caught an extraordinary event on 2023 November 10–18, when the degree of linear polarization of optical synchrotron radiation reached a record value of 47.5%. In stark contrast, the Imaging X-ray Polarimetry Explorer found that the X-ray (Compton scattering or hadron-induced) emission was polarized at less than 7.4% (3σ confidence level). We argue here that this observational result rules out a hadronic origin of the high-energy emission and strongly favors a leptonic (Compton scattering) origin, thereby breaking the degeneracy between hadronic and leptonic emission models for BL Lacertae and demonstrating the power of multiwavelength polarimetry to address this question. Furthermore, the multiwavelength flux and polarization variability, featuring an extremely prominent rise and decay of the optical polarization degree, is interpreted for the first time by the relaxation of a magnetic “spring” embedded in the newly injected plasma. This suggests that the plasma jet can maintain a predominant toroidal magnetic field component parsecs away from the central engine

    Review of mathematical programming applications in water resource management under uncertainty

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    Biomarkers for nutrient intake with focus on alternative sampling techniques

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    Insights from the first flaring activity of a high synchrotron peaked blazar with X-ray polarization and VHE gamma rays

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    Context. Blazars exhibit strong variability across the entire electromagnetic spectrum, including periods of high-flux states commonly known as flares. The physical mechanisms in blazar jets responsible for flares remain poorly understood to date. Aims. Our aim is to better understand the emission mechanisms during blazar flares using X-ray polarimetry and broadband observations from the archetypical TeV blazar Mrk 421, which can be studied with higher accuracy than other blazars that are dimmer and/or located farther away. Methods. We studied a flaring activity from December 2023 that was characterized from radio to very high-energy (VHE; E > 0.1 TeV) gamma rays with MAGIC, Fermi-LAT, Swift, XMM-Newton, and several optical and radio telescopes. These observations included, for the first time for a gamma-ray flare of a blazar, simultaneous X-ray polarization measurements with IXPE, in addition to optical and radio polarimetry data. We quantify the variability and correlations among the multi-band flux and polarization measurements, and describe the varying broadband emission within a theoretical scenario constrained by the polarization data. Results. We find substantial variability in both X-rays and VHE gamma rays throughout the campaign, with the highest VHE flux above 0.2 TeV occurring during the IXPE observing window, and exceeding twice the flux of the Crab Nebula. However, the VHE and X-ray spectra are on average softer, and the correlation between these two bands is weaker than those reported in the previous flares of Mrk 421. IXPE reveals an X-ray polarization degree significantly higher than that at radio and optical frequencies, similar to previous results for Mrk 421 and other high synchrotron peaked blazars. Differently to past observations, the X-ray polarization angle varies by ∼100° on timescales of days, and the polarization degree changes by more than a factor of 4. The highest X-ray polarization degree, analyzed in 12 h time intervals, reaches 26 ± 2%, around which an X-ray counter-clockwise hysteresis loop is measured with XMM-Newton. It suggests that the X-ray emission comes from particles close to the high-energy cutoff, hence possibly probing an extreme case of the Turbulent Extreme Multi-Zone model for which the chromatic trend in the polarization may be more pronounced than theoretically predicted. We model the broadband emission with a simplified stratified jet model throughout the flare. The polarization measurements imply an electron distribution in the X-ray emitting region with a very high minimum Lorentz factor (γ′min≳104), which is expected in electron-ion plasma, as well as a variation of the emitting region size of up to a factor of 3 during the flaring activity. We find no correlation between the fluxes and the evolution of the model parameters, which indicates a stochastic nature of the underlying physical mechanism that likely explains the lack of a tight X-ray/VHE correlation during this flaring activity. Such behavior would be expected in a highly turbulent electron-ion plasma crossing a shock front

    Dynamic analysis of a viscoelastic orthotropic cracked body using the extended finite element method

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    The extended finite element method (XFEM) is found promising in approximating solutions to locally non-smooth features such as jumps, kinks, high gradients, inclusions, voids, shocks, boundary layers or cracks in solid or fluid mechanics problems. The XFEM uses the properties of the partition of unity finite element method (PUFEM) to represent the discontinuities without the corresponding finite element mesh requirements. In the present study numerical simulations of a dynamically loaded orthotropic viscoelastic cracked body are performed using XFEM and the J-integral and stress intensity factors (SIF’s) are calculated. This is achieved by fully (reproducing elements) or partially (blending elements) enriching the elements in the vicinity of the crack tip or body. The enrichment type is restricted to extrinsic mesh-based topological local enrichment in the current work. Thus two types of enrichment functions are adopted viz. the Heaviside step function replicating a jump across the crack and the asymptotic crack tip function particular to the element containing the crack tip or its immediately adjacent ones. A constitutive model for strain-rate dependent moduli and Poisson ratios (viscoelasticity) is formulated. A symmetric double cantilever beam (DCB) of a generic orthotropic material (mixed mode fracture) is studied using the developed XFEM code. The same problem is studied using the viscoelastic constitutive material model implemented in ABAQUS through an implicit user defined material subroutine (UMAT). The results from XFEM correlate well with those of the finite element method (FEM). Three cases viz. static, dynamic and viscoelastic dynamic are studied. It is shown that there is an increase in the value of maximum J-integral when the material exhibits strain rate sensitivity

    Drugs for Treatment of Schizophrenia

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