Three-Dimensional Magnetic Reconnection

The importance of magnetic reconnection as an energy release mechanism in many solar, stellar, magnetospheric and astrophysical phenomena has long been recognised. Reconnection is the only mechanism by which magnetic fields can globally restructure, enabling them to access a lower energy state. Over the past decade, there have been some major advances in our understanding of three-dimensional reconnection. In particular, the key characteristics of 3D magnetohydrodynamic (MHD) reconnection have been determined. For instance, 3D reconnection (i) occurs with or without nulls, (ii) occurs continuously and continually throughout a diffusion region and (iii) is driven by counter rotating flows. Furthermore, analysis of resistive 3D MHD magnetic experiments have revealed some intriguing effects relating to where and how reconnection occurs. To illustrate these new features, a series of constant-resistivity experiments, involving the interaction of two opposite-polarity magnetic sources in an overlying field, are considered. Such a simple interaction represents a typical building block of the Sun's magnetic atmosphere. By following the evolution of the magnetic topology, we are able to explain where, how and at what rate the reconnection occurs. Remarkably there can be up to five energy release sites at anyone time (compared to one in the potential case) and the duration of the interaction increases (more than doubles) as the resistivity decreases (by a factor of 16). The decreased resistivity also leads to a higher peak ohmic dissipation and more energy being released in total, as a result of a greater injection of Poynting flux.Comment: To appear in "Magnetic Coupling between the Interior and the Atmosphere of the Sun", eds. S.S. Hasan and R.J. Rutten, Astrophysics and Space Science Proceedings, Springer-Verlag, Heidelberg, Berlin, 200

Valgus and varus deformity after wide-local excision, brachytherapy and external beam irradiation in two children with lower extremity synovial cell sarcoma: case report

BACKGROUND: Limb-salvage is a primary objective in the management of extremity soft-tissue sarcoma in adults and children. Wide-local excision combined with radiation therapy is effective in achieving local tumor control with acceptable morbidity and good functional outcomes for most patients. CASE PRESENTATION: Two cases of deformity after wide-local excision, brachytherapy and external beam irradiation for lower-extremity synovial cell sarcoma are presented and discussed to highlight contributing factors, time course of radiation effects and orthopedic management. In an effort to spare normal tissues from the long-term effects of radiation therapy, more focal irradiation techniques have been applied to patients with musculoskeletal tumors including brachytherapy and conformal radiation therapy. As illustrated in this report, the use of these techniques results in the asymmetric irradiation of growth plates and contributes to the development of valgus or varus deformity and leg-length discrepancies. CONCLUSIONS: Despite good functional outcomes, progressive deformity in both patients required epiphysiodesis more than 3 years after initial management. There is a dearth of information related to the effects of radiation therapy on the musculoskeletal system in children. Because limb-sparing approaches are to be highlighted in the next generation of cooperative group protocols for children with musculoskeletal tumors, documentation of the effects of surgery and radiation therapy will lead to improved decision making in the selection of the best treatment approach and in the follow-up of these patients

Evaluating the links between schizophrenia and sleep and circadian rhythm disruption

Sleep and circadian rhythm disruption (SCRD) and schizophrenia are often co-morbid. Here, we propose that the co-morbidity of these disorders stems from the involvement of common brain mechanisms. We summarise recent clinical evidence that supports this hypothesis, including the observation that the treatment of SCRD leads to improvements in both the sleep quality and psychiatric symptoms of schizophrenia patients. Moreover, many SCRD-Associated pathologies, such as impaired cognitive performance, are routinely observed in schizophrenia. We suggest that these associations can be explored at a mechanistic level by using animal models. Specifically, we predict that SCRD should be observed in schizophreniarelevant mouse models. There is a rapidly accumulating body of evidence which supports this prediction, as summarised in this review. In light of these emerging data, we highlight other models which warrant investigation, and address the potential challenges associated with modelling schizophrenia and SCRD in rodents. Our view is that an understanding of the mechanistic overlap between SCRD and schizophrenia will ultimately lead to novel treatment approaches, which will not only ameliorate SCRD in schizophrenia patients, but also will improve their broader health problems and overall quality of life. © The Author(s) 2012