17 research outputs found
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
- Author
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- The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group
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- ZZ Chong
- Publication venue
- Publication date
- 09/08/2008
- Field of study
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
Bipolarer Transistor (Injektionstransistor)
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- A Boehringer
- AB Phillips
- BA Beatty
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1996
- Field of study
Distribution of Rare Earth Elements in the Illinois Basin Coals
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- ASTM
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Interrelationship of coal grinding properties and coal petrology
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Theorie des Ladungstransports
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- 01/01/1985
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Power Semiconductor Devices
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Electrical Properties and Microstructure of ZnO-Nb2O5-MnO Ceramics Sintered in the Liquid Phase
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- A.T. Santhanam T.K. Gupta, W.G. Carlson
- AJ Pollard
- DR Clarke
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- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1987
- Field of study
Characterization of coal using electron spin resonance: implications for the formation of inertinite macerals in the Witbank Coalfield, South Africa
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- A Jasper
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- BG Silbernagel
- BG Silbernagel
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- HL Retcofsky
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- I Glasspool
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- International Committee for Coal and Organic Petrology (ICCP)
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- 'Springer Science and Business Media LLC'
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Modes of occurrence of ecotoxic elements in coal from the Upper Silesian Coal Basin, Poland
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- A Alastuey
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- AI Karayigit
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- D Suárez-Ruiz
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- 'Springer Science and Business Media LLC'
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Physics and Modeling of Heterojunction Bipolar Transistors
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- A.F.J. Levi
- AA Grinberg
- AA Grinberg
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- AJ Joseph
- B Bayraktaroglu
- B.K. Oyama
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2003
- Field of study