Resilience in Pre-Columbian Caribbean House-Building: Dialogue Between Archaeology and Humanitarian Shelter

This is the final version of the article. It first appeared from Springer via http://dx.doi.org/10.1007/s10745-015-9741-5This paper responds to questions posed by archaeologists and engineers in the humanitarian sector about relationships between shelter, disasters and resilience. Enabled by an increase in horizontal excavations combined with high-resolution settlement data from excavations in the Dominican Republic, the paper presents a synthesis of Caribbean house data spanning a millennium (1400 BP- 450 BP). An analysis of architectural traits identify the house as an institution that constitutes and catalyses change in an emergent and resilient pathway. The ?Caribbean architectural mode? emerged in a period of demographic expansion and cultural transition, was geographically widespread, different from earlier and mainland traditions and endured the hazards of island and coastal ecologies. We use archaeological analysis at the house level to consider the historical, ecological and regional dimensions of resilience in humanitarian actionThank you to the Museo del Hombre Dominicano for collaboration on the site of El Cabo, to the Netherlands Organisation for Scientific Research and the Faculty of Archaeology, Leiden University for supporting the archaeological research. Kate Crawford?s post-doctoral post at the Department of Civil, Environmental and Geomatic Engineering at University College London was funded by the Engineering and Physical Sciences Research Council

Mutations in a novel gene encoding a CRAL-TRIO domain cause human Cayman ataxia and ataxia/dystonia in the jittery mouse

Cayman ataxia is a recessive congenital ataxia restricted to one area of Grand Cayman Island. Comparative mapping suggested that the locus on 19p13.3 associated with Cayman ataxia might be homologous to the locus on mouse chromosome 10 associated with the recessive ataxic mouse mutant jittery. Screening genes in the region of overlap identified mutations in a novel predicted gene in three mouse jittery alleles, including the first mouse mutation caused by an Alu-related (B1 element) insertion. We found two mutations exclusively in all individuals with Cayman ataxia. The gene ATCAY or Atcay encodes a neuron-restricted protein called caytaxin. Caytaxin contains a CRAL-TRIO motif common to proteins that bind small lipophilic molecules. Mutations in another protein containing a CRAL-TRIO domain, alpha-tocopherol transfer protein (TTPA), cause a vitamin E-responsive ataxia. Three-dimensional protein structural modeling predicts that the caytaxin ligand is more polar than vitamin E. Identification of the caytaxin ligand may help develop a therapy for Cayman ataxia

Long-term development of a cultural landscape: the origins and dynamics of lowland heathland in southern England

The lowland heathlands of southern England comprise ca. 14 % of the total area of this habitat in Europe yet their history is poorly understood. This paper presents the first detailed palaeoecological evidence (combining palynological, microscopic charcoal and radiocarbon data) relating to the origin and long-term dynamics of heathland vegetation in southern England. Valley peat sites, situated on the Lower Greensand Group (coarse-grained sandstones) at Conford (Hampshire) and Hurston Warren (West Sussex) have been investigated. The sequence from Conford indicates the unusually late survival of Pinus sylvestris (to as late as ca. 6050 cal. B.P.) in southern England. This is attributed to edaphic factors and, after ca. 7050 cal. B.P., to frequent fires. After intervening phases of dominance by deciduous woodland, heathland vegetation became established in the proximity of both sites in the Late Bronze Age (ca. 3000 cal. B.P.) with increases in indicators of grazing and burning demonstrating an association between the development of heathland and human activity. Thereafter, the pollen and charcoal records show that the vegetation remained in a dynamic state as the scale and nature of human activity varied through time. Major expansions in the extent of heathland occurred relatively recently; after ca. 1450 cal. B.P. at Hurston Warren and after ca. 850 cal. B.P. at Conford. A review of the palaeoecological evidence suggests that the most intense use and greatest coverage of heathland in southern England probably occurred during the medieval to post-medieval periods