11 research outputs found
An examination of perceived health care availability and unmet health care need in the City of Toronto, Ontario, Canada
Spatial clustering of Diabrotica virgifera virgifera and Agriotes ustulatus in small-scale maize fields without topographic relief drift
Infection-responsive drug delivery from urinary biomaterials controlled by a novel kinetic and thermodynamic approach
Metagenomic Insight Towards Vanillin-Mediated Membrane Biofouling Prevention: In Silico Docking Validation
Biomaterials in Mechano-oncology: Means to Tune Materials to Study
ECM stiffness is emerging as a prognostic marker of tumor aggression or potential for relapse. However, conflicting reports muddle the question of whether increasing or decreasing stiffness is associated with aggressive disease. This chapter discusses this controversy in more detail, but the fact that tumor stiffening plays a key role in cancer progression and in regulating cancer cell behaviors is clear. The impact of having in vitro biomaterial systems that could capture this stiffening during tumor evolution is very high. These cell culture platforms could help reveal the mechanistic underpinnings of this evolution, find new therapeutic targets to inhibit the cross talk between tumor development and ECM stiffening, and serve as better, more physiologically relevant platforms for drug screening.https://scholarlycommons.pacific.edu/soecs-facbooks/1008/thumbnail.jp