28 research outputs found
Balancing repair and tolerance of DNA damage caused by alkylating agents
Get PDFAlkylating agents constitute a major class of frontline chemotherapeutic drugs that inflict cytotoxic DNA damage as their main mode of action, in addition to collateral mutagenic damage. Numerous cellular pathways, including direct DNA damage reversal, base excision repair (BER) and mismatch repair (MMR), respond to alkylation damage to defend against alkylation-induced cell death or mutation. However, maintaining a proper balance of activity both within and between these pathways is crucial for a favourable response of an organism to alkylating agents. Furthermore, the response of an individual to alkylating agents can vary considerably from tissue to tissue and from person to person, pointing to genetic and epigenetic mechanisms that modulate alkylating agent toxicity
Subtrochanteric Fractures: Comparison of Proximal Femur Locking Plate and Intramedullary Locking Nail Fixation Outcome
No full textBone healing of critical size defects of the rat femur after the application of bone marrow aspirate and two different rh-BMP7 concentrations
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Percutaneous cerclage wiring followed by intramedullary nailing for subtrochanteric femoral fractures: a technical note with clinical results
No full textOn the (In)Consistency of Citizen and Municipal Level Indicators of Social Capital and Local Government Performance
Get PDFSocial capital, Consistency, Ecological inference problem,
Fully Automatic Region of Interest Selection in Glomerular Filtration Rate Estimation from 99mTc-DTPA Renogram
No full textProximal femoral nails compared with reverse distal femoral locking plates in intertrochanteric fractures with a compromised lateral wall; a randomised controlled trial
No full textWage moderation in the public sector: The experiences of 11 EMU countries in the recent economic crisis, 2008â2010
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