29 research outputs found
A randomized 500-subject open-label phase 3 clinical trial of minimally invasive surgery plus alteplase in intracerebral hemorrhage evacuation (MISTIE III)
Intracerebral Hemorrhage Volume Reduction and Timing of Intervention Versus Functional Benefit and Survival in the MISTIE III and STICH Trials
Immediate administration of tranexamic acid and reduced incidence of early rebleeding after aneurysmal subarachnoid hemorrhage: a prospective randomized study
Surgical Performance Determines Functional Outcome Benefit in the Minimally Invasive Surgery Plus Recombinant Tissue Plasminogen Activator for Intracerebral Hemorrhage Evacuation (MISTIE) Procedure
Bradykinesia models
Bradykinesia is the cardinal symptom of Parkinson’s disease (PD). It is related to an abnormal
slowness of movement. The causes of PD bradykinesia are not known largely, because there are
multiple brain areas and pathways involved from the neuronal degeneration site (dopamine
neurons in substantia nigra pars compacta (SNc) and ventral tegmental area (VTA)) to the muscles.
Bradykinesia models are mathematical and computational constructs attempting to uncover how
information is processed in the affected brain areas and what are the biophysical mechanisms
giving rise to the observed slowness of movement in PD bradykinesia