82 research outputs found
Light dark matter and dark force at colliders
Light Dark Matter, GeV, with sizable direct detection rate is an
interesting and less explored scenario. Collider searches can be very powerful,
such as through the channel in which a pair of dark matter particle are
produced in association with a jet. It is a generic possibility that the
mediator of the interaction between DM and the nucleus will also be accessible
at the Tevatron and the LHC. Therefore, collider search of the mediator can
provide a more comprehensive probe of the dark matter and its interactions. In
this article, to demonstrate the complementarity of these two approaches, we
focus on the possibility of the mediator being a new gauge boson, which
is probably the simplest model which allows a large direct detection cross
section for a light dark matter candidate. We combine searches in the
monojet+MET channel and dijet resonance search for the mediator. We find that
for the mass of between 250 GeV and 4 TeV, resonance searches at the
colliders provide stronger constraints on this model than the monojet+MET
searches.Comment: 23 pages and 14 figure
Cross-cultural adaptation of the quality of life assessment scale on Alzheimer disease
Natural environments, ancestral diets, and microbial ecology: is there a modern “paleo-deficit disorder”? Part I
Clinical and biological predictors of Alzheimer's disease in patients with amnestic mild cognitive impairment
Naturalness of light neutralino dark matter in pMSSM after LHC, XENON100 and Planck data
Impact of herbivory and pollination on performance and competitive ability of oilseed rape transformed for pollen beetle resistance
Competitive ability of transgenic oilseed rape transformed with a pea lectin gene was estimated by comparisons of its performance when grown in a mixture with its non-transgenic counterpart and when grown singly, with and without pollen beetles present. The experiments were carried out in cages, once with bumblebees as pollinators and once without. In the absence of herbivory but with the presence of bumblebees, singly grown plant lines without lectin generally performed better than lines with lectin. Pollen beetles affected plant growth and reproduction, but there were no consistent differences between the lectin and non-lectin plant lines indicating that the transgenic trait did not protect plants from pest attack. Herbivory reduced the number of seeds when bumblebees were present. In the absence of bumblebees, however, plants produced more seeds with pollen beetles than without, indicating that some pollination was carried out by the beetles. Efficient pollination affected the competitive abilities of the lines; lectin lines were more competitive with bumblebees present and the reverse was true when bumblebees were absent. In the presence of bumblebees, lectin lines gained from being grown mixed with its non-transgenic counterpart. Because the transgenic plants expressed pea lectin in developing pollen it is possible that pollen quality in those plants was reduced, which may explain why the lectin lines had an advantage over non-lectin lines when exchange of pollen between the two plant types was facilitated by bumblebees
Activation of human macrophages by allogeneic islets preparations: inhibition by AOP-RANTES and heparinoids
During transplantation, pancreatic islets release chemokines which promote macrophage attraction, hampering engraftment of islets. The aim of this study was to modulate chemotaxis and the immune response of human macrophages induced by islets. Human monocyte-derived macrophages of healthy subjects were exposed to supernatants of human islets. Chemotaxis, tumour necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) release were evaluated. To modulate migration, human macrophages were incubated in the presence of aminooxypentane-regulated on activation, normal, T-cell expressed, and secreted (AOP-RANTES), a potent antagonist of CCR5. Chemotactic activity of islets supernatant was modulated by the addition of heparin or heparinoids [pentosan and calix[8S]arene (C8S)]. AOP-RANTES significantly reduced, in a dose-dependent manner, macrophage chemotaxis and cytokine release induced by islets supernatant. The chemotactic index was reduced from 3·05 ± 0·27 to 0·71 ± 12, TNF-α from 1205 ± 52 to 202 ± 12 pg/ml, and IL-1β from 234 ± 12 to 10 ± 6 pg/ml. The trapping of chemokines by heparinoids reduced the chemotactic activity of islets supernatant from 3·05 ± 0·27 to 1·2 ± 0·1 with heparin or pentosan and to 1·72 ± 0·22 with C8S, and also decreased the TNF-α release by human macrophages from 1205 ± 35 to 1000 ± 26 (C8S), 250 ± 21 (heparin) and 320 ± 19 (pentosan) pg/ml, and IL-1β from 234 ± 13 to 151 ± 5 (C8S), 50 ± 3 (heparin) and 57 ± 4 (pentosan) pg/ml. In conclusion, AOP-RANTES and heparinoids inhibit human macrophage activation and migration induced by islets supernatant
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