Plasma phosphorylated-tau181 as a predictive biomarker for Alzheimer’s amyloid, tau and FDG PET status

Plasma phosphorylated-tau181 (p-tau181) showed the potential for Alzheimer’s diagnosis and prognosis, but its role in detecting cerebral pathologies is unclear. We aimed to evaluate whether it could serve as a marker for Alzheimer’s pathology in the brain. A total of 1189 participants with plasma p-tau181 and PET data of amyloid, tau or FDG PET were included from ADNI. Cross-sectional relationships of plasma p-tau181 with PET biomarkers were tested. Longitudinally, we further investigated whether different p-tau181 levels at baseline predicted different progression of Alzheimer’s pathological changes in the brain. We found plasma p-tau181 significantly correlated with brain amyloid (Spearman ρ = 0.45, P 18.85 pg/ml) at baseline had a higher risk of pathological progression in brain amyloid (HR: 2.32, 95%CI 1.32–4.08) and FDG PET (3.21, 95%CI 2.06–5.01) status. Plasma p-tau181 may be a sensitive screening test for detecting brain pathologies, and serve as a predictive biomarker for Alzheimer’s pathophysiology

The Political Economy of the Vanishing Marginals: Tiebout Sorting and the American Political System

An overview of our methodology and results suggests that there does exist a trend stationary pattern of increasing vote margins driven by traditional and expanded Tiebout Sorting. First, we have found a long-term trend stationary pattern of increasing vote margins. This was followed by the discovery that within a subset of the trend, 1942 to 1992, a blunt measurement of Tiebout Sorting through the application of urban-rural differences, soliciting information regarding age, class, gender, income, occupation, and race while measuring preferences for public goods through an individual's vote, was statistically significant. Finally, we identified evidence of Tiebout Sorting of both the traditional variety (sorting based on public goods provided) and the economic, but not ideological, portion of the expanded variety (spatial sorting by ideological and economic factors)

Anthropometric traits and sport: study of pre-puberal children of Ravenna province.

After a general analysis of the level of sport participation in the school age population of the province of Ravenna, a study on anthropometric traits and motor tests was carried out on male and female children, 9-11 aged. The purpose of the present research was to investigate the relationship between sport activity and anthropometric or performance characteristics during childhood. As regards somatometric traits, sport practicing children did not show significant differences than non-sport practicing children, also if a possible positive effect of physical activity on the reduction of adiposity was suggested. Results of physiometric and motor ability tests pointed out an improvement in sport children. Physical activity contributes early to improve the physical abilities in childhood, but it appears that physical activityhad not yet influenced the physical development. The present study confirms the existence of a very weak nexus between these variables before puberty on children who maintain a medium-low level of habitual physical activity

Accrescimento e sport a Ravenna.

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