GRB 110709B in the Induced Gravitational Collapse paradigm

Context: GRB110709B is the first source for which Swift BAT triggered twice, with a time separation of ~10 min. The first emission (Ep. 1) goes from 40s before the 1{\deg} trigger up to 60s after it. The second (Ep. 2) goes from 35s before the 2{\deg} trigger to 100s after it.[...] Within the Induced Gravitational Collapse (IGC) model, we assume the progenitor to be a close binary system composed of a core of an evolved star and a Neutron Star (NS). The evolved star explodes as a Supernova (SN) and ejects material that is partially accreted by the NS. We identify this process with Ep. 1. The accretion process brings the NS over its critical mass, thus gravitationally collapsing to a BH. This process leads to the GRB emission, Ep. 2.[...] Aims: We analyze the spectra and time variability of Ep. 1 and 2 and compute the relevant parameters of the binary progenitor[...] in the IGC paradigm. Methods: We perform a time-resolved spectral analysis of Ep. 1 with a blackbody (BB) plus a power-law (PL) spectral model. We analyze Ep. 2 within the Fireshell model, identifying the Proper-GRB (P-GRB) and simulating the light curve and spectrum. We establish the redshift to be z=0.75 [...]. Results: We find for Ep. 1 a BB temperature following a broken PL with time, with the PL slopes at early and late times \alpha=0 and \beta=-4+/-2, respectively, and a break at t=41.21s. The total energy of Ep. 1 and 2 are E_{iso}^1=1.42x10^{53}erg and E_{iso}^2=2.43x10^{52}erg, respectively. We find at transparency a Lorentz factor \Gamma~173, laboratory radius of 6.04x10^{13}cm, P-GRB observed temperature kT_{P-GRB}=12.36keV, baryon load B=0.0057 and P-GRB energy E_{P-GRB}=3.44x10^{50}erg. [...] Conclusions: We interpret GRB110709B as a member of the IGC sources, together with GRB970828, GRB090618 and GRB101023. The XRT data during Ep. 2 offers an unprecedented tool for improving the diagnostic of GRBs emission.Comment: 12 pages, 17 figures, to appear on A&

Lipid-rich histology in a basal-type immuno-profile breast carcinoma: a clinicopathological histochemical and immunohistochemical analysis of a case

We describe the clinicopathological and morphological features of an unusual breast carcinoma classifiable as a lipid-rich variant of ductal invasive carcinoma, with a basal-type immunohistochemical profile. Basal-type breast cancers show no hormonal receptor expression, rarely over-express HER-2 but exhibit molecular high weight cytokeratins, EGFR and c-kit positivity. Special stains and histochemistry tests were used to elucidate the nature of vescicles in the neoplastic cells. Sudan IV was performed on formalin-fixed tissue. Commercially available antibodies tested were: ER, PgR, EGFR, HER2, c-kit, high molecular weight cytokeratins. Cytoplasmic lipids were highlighted as red-orange droplets on Sudan IV staining. As for immunohistochemistry, the tumor showed no reactivity to ER, PgR and HER2 (triple negative), and diffuse and strong positivity to high weight cytokeratins, EGFR and c-kit, such as a basal-type breast carcinoma. A basaloid phenotype in a lipid-rich carcinoma has not been previously reported

High prevalence of anti-hepatitis e virus antibodies among blood donors in central Italy, february to march 2014

Prevalence of anti-hepatitis E virus (HEV) antibodies is highly variable in developed countries, which seems partly due to differences in assay sensitivity. Using validated sensitive assays, we tested 313 blood donors attending a hospital transfusion unit in central Italy in January and February 2014 for anti-HEV IgG and IgM and HEV RNA. Data on HEV exposure were collected from all donors. Overall anti-HEV IgG prevalence was 49% (153/313). Eating raw dried pig-liver sausage was the only independent predictor of HEV infection (adjusted prevalence rate ratio = 2.14; 95% confidence interval: 1.23–3.74). Three donors were positive for either anti-HEV IgM (n = 2; 0.6%) or HEV RNA (n = 2; 0.6%); they were completely asymptomatic, without alanine aminotransferase (ALT) abnormalities. Of the two HEV RNA-positive donors (both harbouring genotype 3), one was anti-HEV IgG- and IgM-positive, the other was anti-HEV IgG- and IgM-negative. The third donor was positive for anti-HEV IgG and IgM but HEV RNA-negative. HEV infection is therefore hyperendemic among blood donors (80% men 18–64 years-old) from central Italy and associated with local dietary habits. Nearly 1% of donors have acute or recent infection, implying potential transmission to blood recipients. Neither ALT nor anti-HEV IgM testing seems useful to prevent transfusion-transmitted HEV infection. © 2016, European Centre for Disease Prevention and Control

Cosmological degeneracy versus cosmography: A cosmographic dark energy model

In this work, we use cosmography to alleviate the degeneracy among cosmological models, proposing a way to parametrize matter and dark energy in terms of cosmokinematics quantities. The recipe of using cosmography allows to expand observable quantities in Taylor series and to directly compare those expansions with data. The strategy involves the expansions of q and j, up to the second-order around a(t) = 1. This includes additional cosmographic parameters which are fixed by current values of q0 and j0. We therefore propose a fully self-consistent parametrization of the total energy density driving the late-time universe speed up. This stratagem does not remove all the degeneracy but enables one to pass from the model-dependent couple of coefficients, ω0 and Ωm,0, to model-independent quantities determined from cosmography. Afterwards, we describe a feasible cosmographic dark energy model, in which matter is fixed whereas dark energy evolves by means of the cosmographic series. Our technique provides robust constraints on cosmokinematic parameters, permitting one to separately bound matter from dark energy densities. Our cosmographic dark energy model turns out to be one parameter only, but differently from the lambda cold dark matter (CDM) paradigm, it does not contain ansatz on the dark energy form. In addition, we even determine the free parameter of our model in suitable 1σ intervals through Monte Carlo analyses based on the Metropolis algorithm. We compare our results with the standard concordance model and we find that our treatment seems to indicate that dark energy slightly evolves in time, reducing to a pure cosmological constant only as z → 0