Equivalence of Light-Front and Covariant Field Theory

In this paper we discuss the relation between the standard covariant quantum field theory and light-front field theory. We define covariant theory by its Feynman diagrams, whereas light-front field theory is defined in terms of light-cone time-ordered diagrams. A general algorithm is proposed that produces the latter from any Feynman diagram. The procedure is illustrated in several cases. Technical problems that occur in the light-front formulation and have no counterpart in the covariant formulation are identified and solved.Comment: 47 Pages, LaTeX with LaTeX figures included in the tex

Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a range of symptoms in infected individuals, from mild respiratory illness to acute respiratory distress syndrome. A systematic understanding of host factors influencing viral infection is critical to elucidate SARS-CoV-2–host interactions and the progression of Coronavirus disease 2019 (COVID-19). Here, we conducted genome-wide CRISPR knockout and activation screens in human lung epithelial cells with endogenous expression of the SARS-CoV-2 entry factors ACE2 and TMPRSS2. We uncovered proviral and antiviral factors across highly interconnected host pathways, including clathrin transport, inflammatory signaling, cell-cycle regulation, and transcriptional and epigenetic regulation. We further identified mucins, a family of high molecular weight glycoproteins, as a prominent viral restriction network that inhibits SARS-CoV-2 infection in vitro and in murine models. These mucins also inhibit infection of diverse respiratory viruses. This functional landscape of SARS-CoV-2 host factors provides a physiologically relevant starting point for new host-directed therapeutics and highlights airway mucins as a host defense mechanism

Performance Of The Alice Experiment At The Cern Lhc

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