95 research outputs found
The relationship between retinal vessel calibre and knee cartilage and BMLs
10.1186/1471-2474-13-255BMC Musculoskeletal Disorders13
Low BRAF and NRAS expression levels are associated with clinical benefit from DTIC therapy and prognosis in metastatic melanoma
Hand osteoarthritis: clinical phenotypes, molecular mechanisms and disease management
Osteoarthritis (OA) is a highly prevalent condition and the hand is the most commonly affected site. Patients with hand OA frequently report symptoms of pain, functional limitations, and frustration in undertaking everyday activities. The condition presents clinically with changes to the bone, ligaments, cartilage and synovial tissue, which can be observed using radiography, ultrasonography or MRI. Hand OA is a heterogeneous disorder and is considered to be multifactorial in aetiology. This review provides an overview of the epidemiology, presentation and burden of hand OA, including an update on hand OA imaging (including the development of novel techniques), disease mechanisms and management. In particular, areas for which new evidence has substantially changed the way we understand, consider and treat hand OA are highlighted. For example, genetic studies, clinical trials and careful prospective imaging studies from the past 5 years are beginning to provide insights into the pathogenesis of hand OA that might uncover new therapeutic targets in disease
Early Warning of Harmful Algal Bloom Risk Using Satellite Ocean Color and Lagrangian Particle Trajectories
Combining Lagrangian trajectories and satellite observations provides a novel basis for monitoring changes in water properties with high temporal and spatial resolution. In this study, a prediction scheme was developed for synthesizing satellite observations and Lagrangian model data for better interpretation of harmful algal bloom (HAB) risk. Thealgorithm can not only predict variations in chlorophyll-a concentration but also changes in spectral properties of the water, which are important for discrimination of different algal species from satellite ocean color. The prediction scheme was applied to regions
along the coast of England to verify its applicability. It was shown that the Lagrangian methodology can significantly improve the coverage of satellite products, and the unique
animations are effective for interpretation of the development of HABs. A comparison between chlorophyll-a predictions and satellite observations further demonstrated the effectiveness of this approach: r2 = 0.81 and a low mean absolute percentage error of 36.9%. Although uncertainties from modelling and the methodology affect the accuracy
of predictions, this approach offers a powerful tool for monitoring the marine ecosystem and for supporting the aquaculture industry with improved early warning of potential HABs
Chromophobe renal cell carcinoma in Iceland: An epidemiological and clinicopathological study
The need for an adapted initiation nomogram during Fiix prothrombin time monitoring of warfarin
Systemic lupus erythematosus after heavy exposure to quartz dust in uranium mines: clinical and serological characteristics
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