65 research outputs found
Optical coherence tomography in optic disk pit maculopathy treated by the macular buckling procedure
PURPOSE: To report optical coherence tomography in optic disk pit
maculopathy treated with macular scleral buckling procedure.
METHODS: Twenty six eyes (26 patients) with optic disk pit maculopathy
were treated with macular buckling procedure and evaluated with optical
coherence tomography. In group 1, five eyes were evaluated with optical
coherence tomography before and after macular buckling procedure. In
group 2, 21 eyes were evaluated with optical coherence tomography after
macular buckling procedure. With optical coherence tomography,
cross-sectional, horizontal retinal images were obtained through the
fovea and optic disk pit.
RESULTS: In group 1, four of five eyes showed absorption of intraretinal
fluid 7 to 9 months after macular buckling procedure. After absorption
of fluid, retinal thickness in the foveal center ranged from 128 to 178
mum. In one eye the channel from optic disk to fovea reopened and fluid
reappeared. In group 2, 20 of 21 eyes showed absorption of intraretinal
schisis and subretinal fluid after macular buckling procedure. After
absorption of fluid, retinal thickness in the foveal center ranged from
119 to 216 mum.
CONCLUSIONS: In optic disk pit maculopathy, optical coherence tomography
enabled morphologic assessment of the retina before and after macular
buckling procedure. In the successfully treated cases the permanent
closure of the connection between the optic disk pit and the
intraretinal schisis was demonstrated. Eventual dis, appearance of
schisis and subretinal fluid was depicted. It was also proved that the
thickness of the macula returned to normal and visual acuity improved.
(C) 2001 by Elsevier Science Inc. All rights reserved
COLOBOMA OF THE OPTIC DISK ASSOCIATED WITH RETINAL VASCULAR ABNORMALITIES
PURPOSE: We studied a case of congenital optic disk pit and coloboma
with associated malformations of the retinal vessels.
METHODS: Slit-lamp biomicroscopy and fluorescein angiography were
performed.
RESULTS: Multiple retinal venous anastomoses associated with a
congenital coloboma and pit of the optic disk were observed. The retinal
vascular anomalies extended from the optic disk to the temporal
periphery.
CONCLUSIONS: We consider the coexistence of retinal venous anastomoses
with optic disk coloboma and pit to be an extremely rare congenital
retinal anomaly
Optical coherence tomography in the study of the Goldmann-Favre syndrome
PURPOSE: To report a case of Goldmann-Favre syndrome with special
emphasis on the optical coherence tomography findings.
METHODS: In a 23-year-old white man with an 8-year history of visual
impairment in both eyes and night blindness, vertical and horizontal
optical coherence tomography images were obtained through the macula and
through the retinoschisis located at the temporal side of the macula.
RESULTS: Optical coherence tomography showed in the left eye a clear
loss of the inner retinal layer at the fovea and the formation of inner
and outer retinal layer holes in the temporally located retinoschisis,
The outer retinal layer hole had rolled edges.
CONCLUSION: In Goldmann-Favre syndrome, optical coherence tomography
demonstrated confluent macular cystoid changes and retinoschisis in both
eyes. In the left eye, a lamellar macular hole and retinoschisis with
inner retinal layer and outer retinal layer holes were observed. The
outer retinal layer hole had rolled edges. (Am J Ophthalmol
2000;129:542-544. (C) 2000 by Elsevier Science Inc. All rights
reserved.)
Cystoid macular edema in a patient with acquired immunodeficiency syndrome and past ocular history of cytomegalovirus retinitis after initiation of protease inhibitors
Purpose: To describe a patient with acquired immunodeficiency syndrome
(AIDS) who presented with cystoid macular edema (CME) which was not
associated with active cytomegalovirus (CMV) retinitis or AIDS-related
microvasculopathy. Method: A 32-year-old man with AIDS and a past ocular
history of inactive CMV retinitis was placed on protease inhibitors when
his CD4(+) T lymphocyte counts dropped to 8 cells/mm(3). Three months
later, after his CD4(+) T lymphocyte counts had increased to 196
cells/mm(3) he complained of micropsia and metamorphopsia in his right
eye of 1 week duration. The patient had a complete ocular examination
including fluorescein angiography (FA). Results: Visual acuity (VA) was
7/10 OD. Fundus examination revealed CME and inactive CMV retinitis, and
FA demonstrated CME and a hot disc. Two transseptal injections of
corticosteroids were administered 2 weeks apart in the right eye as
treatment of the CME. The patient reported gradual visual improvement
and 6 weeks later, his VA was 10/10(-2). CME had resolved clinically and
angiographically. Conclusions: CME in our case is associated with
inactive CMV retinitis and gradually increasing number of CD4(+) T
lymphocytes after initiation of treatment with protease inhibitors. It
may be amenable to regional administration of corticosteroids without
reactivation of retinitis
Regression of neovascular age-related macular degeneration following infliximab therapy
PURPOSE: To describe the effects of the antitumor necrosis factor (TNF)
monoclonal antibody Infliximab systemic therapy on choroidal
neovacularisation (CNV) secondary to age-related macular degeneration
(AMD).
DESIGN: Prospective, noncomparative series of three patients.
METHODS: A subretinal membrane secondary to AMD was documented by
fluoroangiography at baseline in three elderly patients scheduled to
receive Infliximab therapy for inflammatory arthritis (infusions of 5
mg/kg at weeks 0, 2, 6, and every 8 weeks thereafter). Follow-up was
performed at three months post-baseline, as well as during 18 months of
continuing treatment in the first patient.
RESULTS: CNV regressed partially at three months and resolved at six
months in the first patient. Best-corrected visual acuity (BCVA)
increased from 0.05 to 0.2; this effect was sustained at 18 months.
Regression of subretinal membrane and increase of BCVA was also
documented in the other patients. No ocular or extra-ocular side effects
were noted.
CONCLUSIONS: These findings suggest a plausible pathogenetic role of TNF
in CNV secondary to AMD. Additional patients should he studied to
confirm the promising clinical results. (c) 2005 by Elsevier Inc. All
rights reserved
Optical coherence tomography appearance of “drusenoid” pigment epithelial detachment
A case of bilateral “drusenoid” pigment epithelial detachment that
was studied with fundus fluorescein angiography and optical coherence
tomography is described. Fundus fluorescein anglography depicted
staining of the drusen without any sign of pooling of the dye, whereas
optical coherence tomography displayed detachment of the retinal pigment
epithelium. These findings remained unchanged during a 10-month period
A preliminary assessment of macular function by MF-ERG in myopic eyes with CNV with complete response to photodynamic therapy
PURPOSE. To evaluate by multifocal electroretinogram (MF-ERG) macular
function before and after photodynamic therapy (PDT) in myopic eyes with
choroidal neovascularization (CNV).
PATIENTS AND METHODS. Ten eyes with classic subfoveal CNV due to
pathologic myopia were studied with MF-ERG before and after PDT in order
to evaluate the results of PDT with verteporfin. The post-treatment
follow-up was 6 months. Visual acuity testing, ophthalmic examinations,
fluorescein and indocyanine green angiograms, and MF-ERG recordings were
used to evaluate the results of PDT with verteporfin. The post-treatment
period was 6 months.
RESULTS. Before treatment, the electrical response densities in the
foveal and perifoveal areas were apparently decreased in all patients.
Six months after treatment, the mean retinal response densities in the
same areas were found to be higher than before treatment.
CONCLUSIONS. MF-ERG evaluates objectively the macular function in myopic
eyes with CNV After successful PDT, the electrical activity of the
foveal and parafoveal areas is higher than before treatment. This
finding postulates the efficacy of PDT in the treatment of CNV
Fluorescein and indocyanine green angiographic findings in congenital optic disk pit associated with macular detachment
Purpose: To investigate the pattern of congenital optic disk pits
associated with maculopathy using indocyanine green angiography (ICG)
and fluorescein angiography (FA).
Methods: Seventeen consecutive patients with unilateral congenital optic
disk pit complicated by maculopathy were prospectively enrolled in the
study. Complete ophthalmologic examination, color stereophotography,
red-free photography, FA, and ICG angiography were performed on all
patients during their first examination in our department.
Results: Absolute hypofluorescence of the optic disk pit was noted in
all eyes on ICG angiography. On the contrary, all eyes showed early
hypofluorescence and late staining of the optic pit on FA. All 17 eyes
presented a delineated late hyperfluorescence corresponding to the area
of macular elevation on both ICG angiography and FA. The intensity of
the hyperfluorescence was milder in cases with long-standing
maculopathy.
Conclusion: imaging of congenital optic disk pits associated or not with
macular elevation using ICG angiography has not been reported in the
literature. The increased hyperfluorescence in the late phases of the
macular elevation in the studied eyes could be attributed to leakage of
indocyanine or fluorescein dye into the schisis cavity and the
subretinal fluid
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